HOXA7

HOXA7
Identifiers
Aliases	HOXA7 , ANTP, HOX1, HOX1.1, HOX1A, homeobox A7
External IDs	OMIM: 142950; MGI: 96179; HomoloGene: 56001; GeneCards: HOXA7; OMA:HOXA7 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7p15.2 Start 27,153,716 bp [1] End 27,157,936 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6 B3|6 25.4 cM Start 52,191,471 bp [2] End 52,198,834 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte mucosa of transverse colon secondary oocyte sperm biceps brachii tendon of biceps brachii Skeletal muscle tissue of biceps brachii gonad right adrenal gland right adrenal cortex Top expressed in tail of embryo zygote right kidney secondary oocyte thoracic vertebral column proximal tubule muscle of thigh embryo neural tube efferent ductule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific transcription factor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Cellular component nucleus nucleoplasm nuclear membrane Biological process embryonic skeletal system morphogenesis negative regulation of monocyte differentiation negative regulation of keratinocyte differentiation regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II stem cell differentiation transcription, DNA-templated negative regulation of cell-matrix adhesion multicellular organism development angiogenesis negative regulation of transcription, DNA-templated negative regulation of leukocyte migration anterior/posterior pattern specification positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3204 15404 Ensembl ENSG00000122592 ENSMUSG00000038236 UniProt P31268 P02830 RefSeq (mRNA) NM_006896 NM_010455 RefSeq (protein) NP_008827 NP_034585 Location (UCSC) Chr 7: 27.15 – 27.16 Mb Chr 6: 52.19 – 52.2 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein Hox-A7 is a protein that in humans is encoded by the HOXA7 gene. ^{[5] [6] [7]}

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila. ^[7]

See also

• Homeobox

References

1. GRCh38: Ensembl release 89: ENSG00000122592 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038236 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. McAlpine PJ, Shows TB (July 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID   1973146.
6. Scott MP (November 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–553. doi:10.1016/0092-8674(92)90588-4. PMID   1358459. S2CID   13370372.
7. "Entrez Gene: HOXA7 homeobox A7".

Further reading

• Balling R, Mutter G, Gruss P, Kessel M (July 1989). "Craniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice". Cell. 58 (2): 337–347. doi:10.1016/0092-8674(89)90848-9. hdl: 11858/00-001M-0000-002C-3E33-1 . PMID   2568891. S2CID   43658121.
• Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, et al. (December 1989). "The human HOX gene family". Nucleic Acids Research. 17 (24): 10385–10402. doi:10.1093/nar/17.24.10385. PMC   335308 . PMID   2574852.
• Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, et al. (1990). "Organization of human class I homeobox genes". Genome. 31 (2): 745–756. doi:10.1139/g89-133. PMID   2576652.
• Verlinsky Y, Morozov G, Gindilis V, Strom CM, Freidin M, Rechitsky S, et al. (June 1995). "Homeobox gene expression in human oocytes and preembryos". Molecular Reproduction and Development. 41 (2): 127–132. doi:10.1002/mrd.1080410202. PMID   7654365. S2CID   43123886.
• Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". Cytogenetics and Cell Genetics. 73 (1–2): 114–115. doi:10.1159/000134320. PMID   8646877.
• Knoepfler PS, Calvo KR, Chen H, Antonarakis SE, Kamps MP (December 1997). "Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1". Proceedings of the National Academy of Sciences of the United States of America. 94 (26): 14553–14558. Bibcode:1997PNAS...9414553K. doi: 10.1073/pnas.94.26.14553 . PMC   25052 . PMID   9405651.
• Min W, Woo HJ, Lee CS, Lee KK, Yoon WK, Park HW, et al. (March 1998). "307-bp fragment in HOXA7 upstream sequence is sufficient for anterior boundary formation". DNA and Cell Biology. 17 (3): 293–299. doi:10.1089/dna.1998.17.293. PMID   9539109.
• McIlhatton MA, Bremner P, McMullin MF, Maxwell AP, Winter PC, Lappin TR (November 1998). "Sequence characterisation and expression of homeobox HOX A7 in the multi-potential erythroleukaemic cell line TF-1". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1442 (2–3): 329–333. doi:10.1016/s0167-4781(98)00170-5. PMID   9804983.
• Sanger Centre T, Washington University Genome Sequencing Cente T (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi: 10.1101/gr.8.11.1097 . PMID   9847074.
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, et al. (March 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–3496. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC   16267 . PMID   10737800.
• Kim MH, Jin H, Seol EY, Yoo M, Park HW (January 2000). "Sequence analysis and tissue specific expression of human HOXA7". Molecular Biotechnology. 14 (1): 19–24. doi:10.1385/MB:14:1:19. PMID   10911612. S2CID   25333474.
• La Celle PT, Polakowska RR (August 2001). "Human homeobox HOXA7 regulates keratinocyte transglutaminase type 1 and inhibits differentiation". The Journal of Biological Chemistry. 276 (35): 32844–32853. doi: 10.1074/jbc.M104598200 . PMID   11435435.
• Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, et al. (February 2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID   11857506.
• Bertrand FE, Spengeman JD, Shah N, LeBien TW (December 2003). "B-cell development in the presence of the MLL/AF4 oncoprotein proceeds in the absence of HOX A7 and HOX A9 expression". Leukemia. 17 (12): 2454–2459. doi: 10.1038/sj.leu.2403178 . PMID   14562113.

External links

• HOXA7+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.