HMGN2

HMGN2
Identifiers
Aliases	HMGN2 , HMG17, high mobility group nucleosomal binding domain 2
External IDs	OMIM: 163910 HomoloGene: 136792 GeneCards: HMGN2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	26,476,642 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; right uterine tube; ; pituitary gland; ; anterior pituitary; ; bone marrow cells; ; thyroid gland; ; endometrium; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; canal of the cervix;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleosomal DNA binding ; DNA binding ; protein binding ; RNA binding ;
Cellular component	chromatin ; extracellular space ; nucleus ; cytoplasm ;
Biological process	antimicrobial humoral immune response mediated by antimicrobial peptide ;
	Sources:Amigo / QuickGO
Orthologs
	3151
	n/a
	ENSG00000198830
	n/a
	P05204
	n/a
	NM_005517
	n/a
	NP_005508
	n/a
	Wikidata
View/Edit Human

Last updated December 28, 2023

Non-histone chromosomal protein HMG-17 is a protein that in humans is encoded by the HMGN2 gene.^[3]^[4]

Related Research Articles

HMGN proteins are members of the broader class of high mobility group (HMG) chromosomal proteins that are involved in regulation of transcription, replication, recombination, and DNA repair.

High-Mobility Group or HMG is a group of chromosomal proteins that are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair.

Histone H3.1t is a protein that in humans is encoded by the HIST3H3 gene.

Centromere protein A, also known as CENPA, is a protein which in humans is encoded by the CENPA gene. CENPA is a histone H3 variant which is the critical factor determining the kinetochore position(s) on each chromosome in most eukaryotes including humans.

Histone H2B type 1-K is a protein that in humans is encoded by the HIST1H2BK gene.

Non-histone chromosomal protein HMG-14 is a protein that in humans is encoded by the HMGN1 gene.

Histone H2B type 3-B is a protein that in humans is encoded by the HIST3H2BB gene.

Histone H2A type 1 is a protein that in humans is encoded by the HIST1H2AM gene.

Histone H2A type 1-B/E is a protein that in humans is encoded by the HIST1H2AE gene.

Histone H1.1 is a protein that in humans is encoded by the HIST1H1A gene.

Histone H2A type 1 is a protein that in humans is encoded by the HIST1H2AK gene.

Histone H2A type 1-H is a protein that in humans is encoded by the HIST1H2AH gene.

Histone H2A type 1-B/E is a protein that in humans is encoded by the HIST1H2AB gene.

Histone H2A type 3 is a protein that in humans is encoded by the HIST3H2A gene.

Histone H2A type 1-A is a protein that in humans is encoded by the HIST1H2AA gene.

Histone H2A type 2-B is a protein that in humans is encoded by the HIST2H2AB gene.

Histone H2A.J is a protein that in humans is encoded by the H2AFJ gene.

High mobility group nucleosome-binding domain-containing protein 3 is a protein that in humans is encoded by the HMGN3 gene.

High mobility group protein HMG14 and HMG17 also known as nucleosomal binding domain is a family of evolutionarily related proteins.

High mobility group nucleosome-binding domain-containing protein 4 is a transcription factor that in humans is encoded by the HMGN4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198830 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Dracopoli NC, O'Connell P, Elsner TI, Lalouel JM, White RL, Buetow KH, Nishimura DY, Murray JC, Helms C, Mishra SK, et al. (Jul 1991). "The CEPH consortium linkage map of human chromosome 1". Genomics. 9 (4): 686–700. doi:10.1016/0888-7543(91)90362-I. PMID 2037294.
↑ "Entrez Gene: HMGN2 high-mobility group nucleosomal binding domain 2".

Giancotti V, Bandiera A, Buratti E, et al. (1991). "Comparison of multiple forms of the high mobility group I proteins in rodent and human cells. Identification of the human high mobility group I-C protein". Eur. J. Biochem. 198 (1): 211–6. doi:10.1111/j.1432-1033.1991.tb16003.x. PMID 2040281.
Popescu N, Landsman D, Bustin M (1990). "Mapping the human gene coding for chromosomal protein HMG-17". Hum. Genet. 85 (3): 376–8. doi:10.1007/BF00206764. PMID 2394451. S2CID 11160792.
Landsman D, McBride OW, Bustin M (1989). "Human non-histone chromosomal protein HMG-17: identification, characterization, chromosome localization and RFLPs of a functional gene from the large multigene family". Nucleic Acids Res. 17 (6): 2301–14. doi:10.1093/nar/17.6.2301. PMC 317597 . PMID 2565024.
Landsman D, Soares N, Gonzalez FJ, Bustin M (1986). "Chromosomal protein HMG-17. Complete human cDNA sequence and evidence for a multigene family". J. Biol. Chem. 261 (16): 7479–84. doi: 10.1016/S0021-9258(17)38417-X . PMID 3754870.
Leffak M, Trempe JP (1985). "Histone H1 and HMG 14/17 are deposited nonrandomly in the nucleus". Nucleic Acids Res. 13 (13): 4853–69. doi:10.1093/nar/13.13.4853. PMC 321831 . PMID 4022776.
Postnikov YV, Trieschmann L, Rickers A, Bustin M (1995). "Homodimers of chromosomal proteins HMG-14 and HMG-17 in nucleosome cores". J. Mol. Biol. 252 (4): 423–32. doi:10.1006/jmbi.1995.0508. PMID 7563062.
Hock R, Scheer U, Bustin M (1999). "Chromosomal proteins HMG-14 and HMG-17 are released from mitotic chromosomes and imported into the nucleus by active transport". J. Cell Biol. 143 (6): 1427–36. doi:10.1083/jcb.143.6.1427. PMC 2132996 . PMID 9852141.
Herrera JE, Sakaguchi K, Bergel M, et al. (1999). "Specific acetylation of chromosomal protein HMG-17 by PCAF alters its interaction with nucleosomes". Mol. Cell. Biol. 19 (5): 3466–73. doi:10.1128/MCB.19.5.3466. PMC 84139 . PMID 10207070.
Kazmierczak B, Dal Cin P, Rogalla P, et al. (2000). "Regional fine mapping of HMG17 to chromosomal band 1p35". Cancer Genet. Cytogenet. 116 (2): 164–5. doi:10.1016/S0165-4608(99)00137-5. PMID 10640150.
Bergel M, Herrera JE, Thatcher BJ, et al. (2000). "Acetylation of novel sites in the nucleosomal binding domain of chromosomal protein HMG-14 by p300 alters its interaction with nucleosomes". J. Biol. Chem. 275 (15): 11514–20. doi: 10.1074/jbc.275.15.11514 . PMID 10753971.
Bustin M (2001). "Revised nomenclature for high mobility group (HMG) chromosomal proteins". Trends Biochem. Sci. 26 (3): 152–3. doi:10.1016/S0968-0004(00)01777-1. PMID 11246012.
Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC 311086 . PMID 11337467.
Birger Y, Ito Y, West KL, et al. (2001). "HMGN4, a newly discovered nucleosome-binding protein encoded by an intronless gene". DNA Cell Biol. 20 (5): 257–64. doi:10.1089/104454901750232454. PMID 11410162.
Prymakowska-Bosak M, Misteli T, Herrera JE, et al. (2001). "Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin". Mol. Cell. Biol. 21 (15): 5169–78. doi:10.1128/MCB.21.15.5169-5178.2001. PMC 87241 . PMID 11438671.
Porkka K, Laakkonen P, Hoffman JA, et al. (2002). "A fragment of the HMGN2 protein homes to the nuclei of tumor cells and tumor endothelial cells in vivo". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7444–9. Bibcode:2002PNAS...99.7444P. doi: 10.1073/pnas.062189599 . PMC 124250 . PMID 12032302.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID 16710414.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198830 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2037294-3] Dracopoli NC, O'Connell P, Elsner TI, Lalouel JM, White RL, Buetow KH, Nishimura DY, Murray JC, Helms C, Mishra SK, et al. (Jul 1991). "The CEPH consortium linkage map of human chromosome 1". Genomics. 9 (4): 686–700. doi:10.1016/0888-7543(91)90362-I. PMID 2037294.

[entrez-4] "Entrez Gene: HMGN2 high-mobility group nucleosomal binding domain 2".

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[3]

[4]

HMGN2

Contents

See also

Related Research Articles

References

Further reading