HMGN4

HMGN4
Identifiers
Aliases	HMGN4 , HMG17L3, NHC, high mobility group nucleosomal binding domain 4
External IDs	HomoloGene: 105484 GeneCards: HMGN4
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p22.2 Start 26,538,366 bp [1] End 26,546,933 bp [1]
RNA expression pattern Bgee Top expressed in blood smooth muscle tissue thymus kidney Germinal epithelium endometrium lymph node parietal pleura thyroid gland More reference expression data BioGPS n/a
Orthologs
Species	Human	Mouse
Entrez	10473	n/a
Ensembl	ENSG00000182952	n/a
UniProt	O00479	n/a
RefSeq (mRNA)	NM_006353	n/a
RefSeq (protein)	NP_006344 NP_006344.1	n/a
Location (UCSC)	Chr 6: 26.54 – 26.55 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

High mobility group nucleosome-binding domain-containing protein 4 is a transcription factor that in humans is encoded by the HMGN4 gene. ^{[3] [4]}

Function

The protein encoded by this gene, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Transcript variants utilizing alternative polyadenylation signals exist for this gene. ^[3]

See also

• High-mobility group

References

1. GRCh38: Ensembl release 89: ENSG00000182952 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: high mobility group nucleosomal binding domain 4".
4. Birger Y, Ito Y, West KL, Landsman D, Bustin M (May 2001). "HMGN4, a newly discovered nucleosome-binding protein encoded by an intronless gene". DNA Cell Biol. 20 (5): 257–64. doi:10.1089/104454901750232454. PMID   11410162.

Further reading

• Ruddy DA, Kronmal GS, Lee VK, et al. (1997). "A 1.1-Mb transcript map of the hereditary hemochromatosis locus". Genome Res. 7 (5): 441–56. doi: 10.1101/gr.7.5.441 . PMID   9149941.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.