Homeobox protein MOX-1 is a protein that in humans is encoded by the MEOX1 gene. [5] [6]
Homeobox protein MOX-1 is a protein that in humans is encoded by the MEOX1 gene. [5] [6]
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described. [6]
MEOX1 has been shown to interact with PAX1 [7] and PAX3. [7]
A homeobox is a DNA sequence, around 180 base pairs long, found within genes that are involved in the regulation of patterns of anatomical development (morphogenesis) in animals, fungi, plants, and numerous single cell eukaryotes. Homeobox genes encode homeodomain protein products that are transcription factors sharing a characteristic protein fold structure that binds DNA to regulate expression of target genes. Homeodomain proteins regulate gene expression and cell differentiation during early embryonic development, thus mutations in homeobox genes can cause developmental disorders.
Pre-B-cell leukemia transcription factor 1 is a protein that in humans is encoded by the PBX1 gene.
Msh homeobox 1, also known as MSX1, is a protein that in humans is encoded by the MSX1 gene. MSX1 transcripts are not only found in thyrotrope-derived TSH cells, but also in the TtT97 thyrotropic tumor, which is a well differentiated hyperplastic tissue that produces both TSHß- and a-subunits and is responsive to thyroid hormone. MSX1 is also expressed in highly differentiated pituitary cells which until recently was thought to be expressed exclusively during embryogenesis. There is a highly conserved structural organization of the members of the MSX family of genes and their abundant expression at sites of inductive cell–cell interactions in the embryo suggest that they have a pivotal role during early development.
Homeobox protein MSX-2 is a protein that in humans is encoded by the MSX2 gene.
Cone-rod homeobox protein is a protein that in humans is encoded by the CRX gene.
Homeobox protein engrailed-2 is a protein that in humans is encoded by the EN2 gene. It is a member of the engrailed gene family.
Homeobox protein DLX-5 is a protein that in humans is encoded by the distal-less homeobox 5 gene, or DLX5 gene. DLX5 is a member of DLX gene family.
Homeobox protein DLX-3 is a protein that in humans is encoded by the DLX3 gene.
Homeobox protein DLX-4 is a protein that in humans is encoded by the DLX4 gene.
Paired-like homeodomain 1 is a protein that in humans is encoded by the PITX1 gene.
Homeobox protein Hox-D4 is a protein that in humans is encoded by the HOXD4 gene.
Homeobox protein MOX-2 is a protein that in humans is encoded by the MEOX2 gene.
Homeobox protein SIX5 is a protein that in humans is encoded by the SIX5 gene.
Paired box protein Pax-1 is a protein that in humans is encoded by the PAX1 gene.
Homeobox protein DLX-2 is a protein that in humans is encoded by the DLX2 gene.
Homeobox protein Hox-C11 is a protein that in humans is encoded by the HOXC11 gene.
Homeobox protein Meis2 is a protein that in humans is encoded by the MEIS2 gene.
Homeobox protein SIX2 is a protein that in humans is encoded by the SIX2 gene.
Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene.
PBX/Knotted 1 Homeobox 2 (PKNOX2) protein belongs to the three amino acid loop extension (TALE) class of homeodomain proteins, and is encoded by PKNOX2 gene in humans. The protein regulates the transcription of other genes and affects anatomical development.
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