MEOX1

MEOX1
Identifiers
Aliases	MEOX1 , KFS2, MOX1, mesenchyme homeobox 1
External IDs	OMIM: 600147; MGI: 103220; HomoloGene: 3326; GeneCards: MEOX1; OMA:MEOX1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q21.31 Start 43,640,389 bp [1] End 43,661,922 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 D|11 65.48 cM Start 101,768,336 bp [2] End 101,785,200 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii subcutaneous adipose tissue apex of heart Achilles tendon parietal pleura lactiferous duct abdominal fat synovial joint synovial membrane saphenous vein Top expressed in somite semi-lunar valve intermediate mesoderm aortic valve ankle joint endocardial cushion sclerotome interventricular septum urethra primitive streak More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding DNA-binding transcription factor activity HMG box domain binding chromatin binding RNA polymerase II cis-regulatory region sequence-specific DNA binding core promoter sequence-specific DNA binding protein binding DNA-binding transcription activator activity, RNA polymerase II-specific molecular function DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nucleus Biological process regulation of transcription, DNA-templated somite specification transcription by RNA polymerase II sclerotome development transcription, DNA-templated multicellular organism development hematopoietic stem cell differentiation positive regulation of transcription by RNA polymerase II somite development biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4222 17285 Ensembl ENSG00000005102 ENSMUSG00000001493 UniProt P50221 P32442 RefSeq (mRNA) NM_001040002 NM_004527 NM_013999 NM_010791 RefSeq (protein) NP_001035091 NP_004518 NP_054705 NP_034921 Location (UCSC) Chr 17: 43.64 – 43.66 Mb Chr 11: 101.77 – 101.79 Mb PubMed search [3] [4]
Wikidata
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Mesenchyme homeobox 1 (MEOX1) is a protein that in humans is encoded by the MEOX1 gene. ^{[5] [6]}

Function

This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing transcription factor genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described. ^[6]

Interactions

MEOX1 has been shown to interact with PAX1 ^[7] and PAX3. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000005102 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001493 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Futreal PA, Cochran C, Rosenthal J, Miki Y, Swenson J, Hobbs M, Bennett LM, Haugen-Strano A, Marks J, Barrett JC (Jan 1995). "Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture". Hum Mol Genet. 3 (8): 1359–64. doi:10.1093/hmg/3.8.1359. PMID   7987315.
6. "Entrez Gene: MEOX1 mesenchyme homeobox 1".
7. Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (Jun 2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. 499 (3): 274–8. doi: 10.1016/S0014-5793(01)02556-X . PMID   11423130. S2CID   40668112.

Further reading

• Jones KA, Black DM, Brown MA, Griffiths BL, Nicolai HM, Chambers JA, Bonjardim M, Xu CF, Boyd M, McFarlane R (1995). "The detailed characterisation of a 400 kb cosmid walk in the BRCA1 region: identification and localisation of 10 genes including a dual-specificity phosphatase". Hum. Mol. Genet. 3 (11): 1927–34. doi:10.1093/hmg/3.11.1927. PMID   7874108.
• Stelnicki EJ, Kömüves LG, Holmes D, Clavin W, Harrison MR, Adzick NS, Largman C (1997). "The human homeobox genes MSX-1, MSX-2, and MOX-1 are differentially expressed in the dermis and epidermis in fetal and adult skin". Differentiation. 62 (1): 33–41. doi: 10.1046/j.1432-0436.1997.6210033.x . PMID   9373945.
• Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. 499 (3): 274–8. doi: 10.1016/S0014-5793(01)02556-X . PMID   11423130. S2CID   40668112.
• Petropoulos H, Gianakopoulos PJ, Ridgeway AG, Skerjanc IS (2004). "Disruption of Meox or Gli activity ablates skeletal myogenesis in P19 cells". J. Biol. Chem. 279 (23): 23874–81. doi: 10.1074/jbc.M312612200 . PMID   15039437.
• Gianakopoulos PJ, Skerjanc IS (2005). "Hedgehog signaling induces cardiomyogenesis in P19 cells". J. Biol. Chem. 280 (22): 21022–8. doi: 10.1074/jbc.M502977200 . PMID   15793308.
• Wissmüller S, Kosian T, Wolf M, Finzsch M, Wegner M (2006). "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors". Nucleic Acids Res. 34 (6): 1735–44. doi:10.1093/nar/gkl105. PMC   1421504 . PMID   16582099.