HIVEP3

Last updated
HIVEP3
Identifiers
Aliases HIVEP3 , Hivep3, 2900056N03Rik, A130075N07, AI848000, E030045D18Rik, KBP-1, KBP1, Rc, Schnurri-3, Shn3, Zas3, ZNF40C, human immunodeficiency virus type I enhancer binding protein 3, Kappa Recognition Component (Krc), KRC, HIVEP zinc finger 3
External IDs OMIM: 606649 MGI: 106589 HomoloGene: 7803 GeneCards: HIVEP3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001127714
NM_024503

NM_010657

RefSeq (protein)

NP_001121186
NP_078779

NP_034787

Location (UCSC) Chr 1: 41.51 – 42.04 Mb Chr 4: 119.73 – 120.14 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transcription factor HIVEP3 is a protein that in humans is encoded by the HIVEP3 gene. [5] [6]

Contents

Function

Members of the ZAS family, such as ZAS3 (HIVEP3), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine -rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM] [6]

It regulates osteoblasts. [7]

Interactions

HIVEP3 has been shown to interact with TRAF1 [8] and TRAF2. [8]

Related Research Articles

TRAF2

TNF receptor-associated factor 2 is a protein that in humans is encoded by the TRAF2 gene.

Lymphotoxin beta receptor

Lymphotoxin beta receptor (LTBR), also known as tumor necrosis factor receptor superfamily member 3 (TNFRSF3), is a cell surface receptor for lymphotoxin involved in apoptosis and cytokine release. It is a member of the tumor necrosis factor receptor superfamily.

TRAF1

TNF receptor-associated factor 1 is a protein that in humans is encoded by the TRAF1 gene.

TNFAIP3

Tumor necrosis factor, alpha-induced protein 3 or A20 is a protein that in humans is encoded by the TNFAIP3 gene.

ZBTB17

Zinc finger and BTB domain-containing protein 17 is a protein that in humans is encoded by the ZBTB17 gene.

ZNF148

Zinc finger protein 148 is a protein that in humans is encoded by the ZNF148 gene.

BPTF

Nucleosome-remodeling factor subunit BPTF is a protein that in humans is encoded by the BPTF gene.

TRAF4

TNF receptor-associated factor 4 (TRAF4) also known as RING finger protein 83 (RNF83) is a protein that in humans is encoded by the TRAF4 gene.

ZNF593

Zinc finger protein 593 is a protein that in humans is encoded by the ZNF593 gene.

TAX1BP1

Tax1-binding protein 1 is a protein that in humans is encoded by the TAX1BP1 gene.

HIVEP1

Zinc finger protein 40 is a protein that in humans is encoded by the HIVEP1 gene.

ZHX3

Zinc fingers and homeoboxes protein 3 is a protein that in humans is encoded by the ZHX3 gene.

ZNF655

Zinc finger protein 655 is a protein that in humans is encoded by the ZNF655 gene.

RREB1

Ras-responsive element-binding protein 1 is a protein that in humans is encoded by the RREB1 gene.

HIVEP2

Transcription factor HIVEP2 is a protein that in humans is encoded by the HIVEP2 gene.

ZHX2

Zinc fingers and homeoboxes protein 2 is a protein that in humans is encoded by the ZHX2 gene.

ZNF346

Zinc finger protein 346 is a protein that in humans is encoded by the ZNF346 gene.

ZNF7

Zinc finger protein 7 is a protein that in humans is encoded by the ZNF7 gene.

ZNF22

Zinc finger protein 22 is a protein that in humans is encoded by the ZNF22 gene.

OTUD7B

OTU domain-containing protein 7B is a protein that in humans is encoded by the OTUD7B gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000127124 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028634 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hicar MD, Liu Y, Allen CE, Wu LC (Jan 2001). "Structure of the human zinc finger protein HIVEP3: molecular cloning, expression, exon-intron structure, and comparison with paralogous genes HIVEP1 and HIVEP2". Genomics. 71 (1): 89–100. doi:10.1006/geno.2000.6425. PMID   11161801.
  6. 1 2 "Entrez Gene: HIVEP3 human immunodeficiency virus type I enhancer binding protein 3".
  7. Glimcher, LH; Jones, DC; Wein, MN (November 2007). "Control of postnatal bone mass by the zinc finger adapter protein Schnurri-3". Annals of the New York Academy of Sciences. 1116 (1): 174–81. Bibcode:2007NYASA1116..174G. doi:10.1196/annals.1402.044. PMID   18083927. S2CID   25260678.
  8. 1 2 Oukka M, Kim ST, Lugo G, Sun J, Wu LC, Glimcher LH (Jan 2002). "A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2". Molecular Cell. 9 (1): 121–31. doi: 10.1016/S1097-2765(01)00434-8 . PMID   11804591.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.