Transcription factor E2F3 is a protein that in humans is encoded by the E2F3 gene. [5]
Transcription factor E2F3 is a protein that in humans is encoded by the E2F3 gene. [5]
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. Alternative gene splicing is found in the mouse homolog, but has not reported in human yet. [6]
E2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes. Three of them are activators: E2F1, 2 and E2F3a. Six others act as suppressors: E2F3b, E2F4-8. All of them are involved in the cell cycle regulation and synthesis of DNA in mammalian cells. E2Fs as TFs bind to the TTTCCCGC consensus binding site in the target promoter sequence.
TEAD2, together with TEAD1, defines a novel family of transcription factors, the TEAD family, highly conserved through evolution. TEAD proteins were notably found in Drosophila (Scalloped), C. elegans, S. cerevisiae and A. nidulans. TEAD2 has been less studied than TEAD1 but a few studies revealed its role during development.
Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene.
Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene.
POU domain, class 2, transcription factor 1 is a protein that in humans is encoded by the POU2F1 gene.
Lymphoid enhancer-binding factor 1 (LEF1) is a protein that in humans is encoded by the LEF1 gene.
Transcription factor E2F4 is a protein that in humans is encoded by the E2F4 gene.
G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene.
Transcription elongation factor SPT5 is a protein that in humans is encoded by the SUPT5H gene.
Transcription factor E2F2 is a protein that in humans is encoded by the E2F2 gene.
Retinoblastoma-like 1 (p107), also known as RBL1, is a protein that in humans is encoded by the RBL1 gene.
Transcription factor Dp-1 is a protein that in humans is encoded by the TFDP1 gene.
Hepatic leukemia factor is a protein that in humans is encoded by the HLF gene.
E3 ubiquitin-protein ligase RING1 is an enzyme that in humans is encoded by the RING1 gene.
Transcription factor E2F5 is a protein that in humans is encoded by the E2F5 gene.
Paired amphipathic helix protein Sin3b is a protein that in humans is encoded by the SIN3B gene.
Protein NPAT also known as nuclear protein of the ATM locus is a protein that in humans is encoded by the NPAT gene.
Transcription factor Dp-2 is a protein that in humans is encoded by the TFDP2 gene.
RING1 and YY1-binding protein is a protein that in humans is encoded by the RYBP gene.
The retinoblastoma protein is a tumor suppressor protein that is dysfunctional in several major cancers. One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. When the cell is ready to divide, pRb is phosphorylated, inactivating it, and the cell cycle is allowed to progress. It is also a recruiter of several chromatin remodeling enzymes such as methylases and acetylases.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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