E2F3

E2F3
Identifiers
Aliases	E2F3 , E2F-3, E2F transcription factor 3
External IDs	OMIM: 600427; MGI: 1096340; HomoloGene: 74413; GeneCards: E2F3; OMA:E2F3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p22.3 Start 20,401,879 bp [1] End 20,493,714 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 A3.2 Start 30,090,558 bp [2] End 30,170,046 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell Brodmann area 23 middle temporal gyrus endothelial cell tendon of biceps brachii gingival epithelium tibia cartilage tissue visceral pleura bone marrow Top expressed in primitive streak mandibular prominence maxillary prominence cumulus cell medullary collecting duct abdominal wall atrium tail of embryo hair follicle genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein binding protein dimerization activity RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific transcription factor binding Cellular component nucleus transcription regulator complex RNA polymerase II transcription regulator complex nucleoplasm Biological process positive regulation of transcription, DNA-templated negative regulation of fat cell proliferation cell cycle transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of cell population proliferation positive regulation of transcription by RNA polymerase II positive regulation of vascular associated smooth muscle cell apoptotic process negative regulation of transcription by RNA polymerase II regulation of cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1871 13557 Ensembl ENSG00000112242 ENSMUSG00000016477 UniProt O00716 O35261 RefSeq (mRNA) NM_001243076 NM_001949 NM_001289920 NM_010093 NM_001359994 RefSeq (protein) NP_001230005 NP_001940 NP_001276849 NP_034223 NP_001346923 Location (UCSC) Chr 6: 20.4 – 20.49 Mb Chr 13: 30.09 – 30.17 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transcription factor E2F3 is a protein that in humans is encoded by the E2F3 gene. ^[5]

Function

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. Alternative gene splicing is found in the mouse homolog, but has not reported in human yet. ^[6]

Interactions

E2F3 has been shown to interact with TFE3, ^[7] IGF2. ^[8] and RYBP. ^[9]

See also

• E2F

References

1. GRCh38: Ensembl release 89: ENSG00000112242 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000016477 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K (Dec 1993). "The retinoblastoma protein binds to a family of E2F transcription factors". Molecular and Cellular Biology. 13 (12): 7813–25. doi:10.1128/mcb.13.12.7813. PMC   364853 . PMID   8246996.
6. "Entrez Gene: E2F3 E2F transcription factor 3".
7. Giangrande PH, Hallstrom TC, Tunyaplin C, Calame K, Nevins JR (Jun 2003). "Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor". Molecular and Cellular Biology. 23 (11): 3707–20. doi:10.1128/MCB.23.11.3707-3720.2003. PMC   155231 . PMID   12748276.
8. Julian CL, Jeffrey B (March 25, 2013). "Evidence that Igf2 down-regulation in postnatal tissues and up-regulation in malignancies is driven by transcription factor E2f3". Proceedings of the National Academy of Sciences of the United States of America. 110 (15): 6181–86. Bibcode:2013PNAS..110.6181L. doi: 10.1073/pnas.1219079110 . PMC   3625270 . PMID   23530192.
9. Schlisio S, Halperin T, Vidal M, Nevins JR (Nov 2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". The EMBO Journal. 21 (21): 5775–86. doi:10.1093/emboj/cdf577. PMC   131074 . PMID   12411495.

Further reading

• Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 1 (5): 223–9. doi: 10.1093/dnares/1.5.223 . PMID   7584044.
• Wu CL, Zukerberg LR, Ngwu C, Harlow E, Lees JA (May 1995). "In vivo association of E2F and DP family proteins". Molecular and Cellular Biology. 15 (5): 2536–46. doi:10.1128/mcb.15.5.2536. PMC   230484 . PMID   7739537.
• Karlseder J, Rotheneder H, Wintersberger E (Apr 1996). "Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F". Molecular and Cellular Biology. 16 (4): 1659–67. doi:10.1128/mcb.16.4.1659. PMC   231152 . PMID   8657141.
• Rogers KT, Higgins PD, Milla MM, Phillips RS, Horowitz JM (Jul 1996). "DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo". Proceedings of the National Academy of Sciences of the United States of America. 93 (15): 7594–9. Bibcode:1996PNAS...93.7594R. doi: 10.1073/pnas.93.15.7594 . PMC   38791 . PMID   8755520.
• Magae J, Wu CL, Illenye S, Harlow E, Heintz NH (Jul 1996). "Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members". Journal of Cell Science. 109 (7): 1717–26. doi:10.1242/jcs.109.7.1717. PMID   8832394.
• Hofmann F, Livingston DM (Apr 1996). "Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit". Genes & Development. 10 (7): 851–61. doi: 10.1101/gad.10.7.851 . PMID   8846921.
• Lindeman GJ, Gaubatz S, Livingston DM, Ginsberg D (May 1997). "The subcellular localization of E2F-4 is cell-cycle dependent". Proceedings of the National Academy of Sciences of the United States of America. 94 (10): 5095–100. Bibcode:1997PNAS...94.5095L. doi: 10.1073/pnas.94.10.5095 . PMC   24637 . PMID   9144196.
• Dynlacht BD, Moberg K, Lees JA, Harlow E, Zhu L (Jul 1997). "Specific regulation of E2F family members by cyclin-dependent kinases". Molecular and Cellular Biology. 17 (7): 3867–75. doi:10.1128/mcb.17.7.3867. PMC   232239 . PMID   9199321.
• Pierce AM, Schneider-Broussard R, Philhower JL, Johnson DG (Jul 1998). "Differential activities of E2F family members: unique functions in regulating transcription". Molecular Carcinogenesis. 22 (3): 190–8. doi:10.1002/(SICI)1098-2744(199807)22:3<190::AID-MC7>3.0.CO;2-P. PMID   9688145. S2CID   42749241.
• Humbert PO, Verona R, Trimarchi JM, Rogers C, Dandapani S, Lees JA (Mar 2000). "E2f3 is critical for normal cellular proliferation". Genes & Development. 14 (6): 690–703. doi:10.1101/gad.14.6.690. PMC   316459 . PMID   10733529.
• Takahashi Y, Rayman JB, Dynlacht BD (Apr 2000). "Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression". Genes & Development. 14 (7): 804–16. doi:10.1101/gad.14.7.804. PMC   316494 . PMID   10766737.
• Leone G, Nuckolls F, Ishida S, Adams M, Sears R, Jakoi L, Miron A, Nevins JR (May 2000). "Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins". Molecular and Cellular Biology. 20 (10): 3626–32. doi:10.1128/MCB.20.10.3626-3632.2000. PMC   85655 . PMID   10779352.
• He Y, Armanious MK, Thomas MJ, Cress WD (Jul 2000). "Identification of E2F-3B, an alternative form of E2F-3 lacking a conserved N-terminal region". Oncogene. 19 (30): 3422–33. doi: 10.1038/sj.onc.1203682 . PMID   10918599.
• Yamochi T, Semba K, Tsuji K, Mizumoto K, Sato H, Matsuura Y, Nishimoto I, Matsuoka M (Dec 2001). "ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3)". European Journal of Biochemistry. 268 (23): 6076–82. doi:10.1046/j.0014-2956.2001.02555.x. PMID   11733001.
• Weinmann AS, Yan PS, Oberley MJ, Huang TH, Farnham PJ (Jan 2002). "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis". Genes & Development. 16 (2): 235–44. doi:10.1101/gad.943102. PMC   155318 . PMID   11799066.
• Ren B, Cam H, Takahashi Y, Volkert T, Terragni J, Young RA, Dynlacht BD (Jan 2002). "E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints". Genes & Development. 16 (2): 245–56. doi:10.1101/gad.949802. PMC   155321 . PMID   11799067.
• He Y, Cress WD (Jun 2002). "E2F-3B is a physiological target of cyclin A". The Journal of Biological Chemistry. 277 (26): 23493–9. doi: 10.1074/jbc.M202629200 . PMID   11980909.
• Schlisio S, Halperin T, Vidal M, Nevins JR (Nov 2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". The EMBO Journal. 21 (21): 5775–86. doi:10.1093/emboj/cdf577. PMC   131074 . PMID   12411495.

External links

• E2F3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.