TEAD3

Last updated
TEAD3
Protein TEAD3 PDB 2hzd.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TEAD3 , DTEF-1, ETFR-1, TEAD-3, TEAD5, TEF-5, TEF5, TEA domain transcription factor 3
External IDs OMIM: 603170 MGI: 109241 HomoloGene: 81821 GeneCards: TEAD3
Orthologs
SpeciesHumanMouse
Entrez

7005

21678

Ensembl

ENSG00000007866

ENSMUSG00000002249

UniProt

Q99594

P70210

RefSeq (mRNA)

NM_003214
NM_001395214

NM_001098226
NM_001204156
NM_011566

RefSeq (protein)

NP_003205

NP_001091696
NP_001191085
NP_035696

Location (UCSC) Chr 6: 35.47 – 35.5 Mb Chr 17: 28.55 – 28.57 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transcriptional enhancer factor TEF-5 is a protein that in humans is encoded by the TEAD3 gene. [5] [6] [7]

Contents

Function

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. [8] Members of the family in mammals are TEAD1, TEAD2, TEAD3, TEAD4. Transcriptional coregulators, such as WWTR1 (TAZ) bind to these transcription factors. TEAD3 is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. It is expressed in nervous system and muscle in fish embryos. [9] Translation of this protein is initiated at a non-AUG (AUA) start codon. [7]

Related Research Articles

<span class="mw-page-title-main">Human placental lactogen</span> Polypeptide placental hormone in humans

Human placental lactogen (hPL), also called human chorionic somatomammotropin (hCS), is a polypeptide placental hormone, the human form of placental lactogen. Its structure and function are similar to those of human growth hormone. It modifies the metabolic state of the mother during pregnancy to facilitate energy supply to the fetus. hPL has anti-insulin properties. hPL is a hormone secreted by the syncytiotrophoblast during pregnancy. Like human growth hormone, hPL is encoded by genes on chromosome 17q22-24. It was identified in 1963.

<span class="mw-page-title-main">Steroidogenic factor 1</span> Protein-coding gene in humans

The steroidogenic factor 1 (SF-1) protein is a transcription factor involved in sex determination by controlling activity of genes related to the reproductive glands or gonads and adrenal glands. This protein is encoded by the NR5A1 gene, a member of the nuclear receptor subfamily, located on the long arm of chromosome 9 at position 33.3. It was originally identified as a regulator of genes encoding cytochrome P450 steroid hydroxylases, however, further roles in endocrine function have since been discovered.

<span class="mw-page-title-main">Peroxisome proliferator-activated receptor gamma</span> Protein-coding gene in the species Homo sapiens

Peroxisome proliferator- activated receptor gamma, also known as the glitazone reverse insulin resistance receptor, or NR1C3 is a type II nuclear receptor functioning as a transcription factor that in humans is encoded by the PPARG gene.

<span class="mw-page-title-main">TEAD2</span> Protein-coding gene in the species Homo sapiens

TEAD2, together with TEAD1, defines a novel family of transcription factors, the TEAD family, highly conserved through evolution. TEAD proteins were notably found in Drosophila (Scalloped), C. elegans, S. cerevisiae and A. nidulans. TEAD2 has been less studied than TEAD1 but a few studies revealed its role during development.

<span class="mw-page-title-main">MEF2C</span> Protein-coding gene in the species Homo sapiens

Myocyte-specific enhancer factor 2C also known as MADS box transcription enhancer factor 2, polypeptide C is a protein that in humans is encoded by the MEF2C gene. MEF2C is a transcription factor in the Mef2 family.

<span class="mw-page-title-main">ATF1</span> Protein-coding gene in the species Homo sapiens

Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.

<span class="mw-page-title-main">Placental growth factor</span>

Placental growth factor(PlGF) is a protein that in humans is encoded by the PGF gene.

<span class="mw-page-title-main">YAP1</span> Protein-coding gene in the species Homo sapiens

YAP1, also known as YAP or YAP65, is a protein that acts as a transcription coregulator that promotes transcription of genes involved in cellular proliferation and suppressing apoptotic genes. YAP1 is a component in the hippo signaling pathway which regulates organ size, regeneration, and tumorigenesis. YAP1 was first identified by virtue of its ability to associate with the SH3 domain of Yes and Src protein tyrosine kinases. YAP1 is a potent oncogene, which is amplified in various human cancers.

<span class="mw-page-title-main">Growth hormone 2</span> Variant of somatotropin produced by placenta

Growth hormone 2 (GH2), also known more commonly as placental growth hormone (PGH) or as growth hormone variant (GH-V), is a protein that in humans is encoded by the GH2 gene. It is produced by and secreted from the placenta during pregnancy, and becomes the predominant form of growth hormone (GH) in the body during this time. Its cogener is growth hormone 1 (GH1), or pituitary growth hormone.

<span class="mw-page-title-main">TEAD1</span> Protein-coding gene in the species Homo sapiens

Transcriptional enhancer factor TEF-1 also known as TEA domain family member 1 (TEAD1) and transcription factor 13 (TCF-13) is a protein that in humans is encoded by the TEAD1 gene. TEAD1 was the first member of the TEAD family of transcription factors to be identified.

<span class="mw-page-title-main">Sp4 transcription factor</span> Protein-coding gene in the species Homo sapiens

Transcription factor Sp4 is a protein that in humans is encoded by the SP4 gene.

<i>DBP</i> (gene) Protein-coding gene in the species Homo sapiens

D site of albumin promoter binding protein, also known as DBP, is a protein which in humans is encoded by the DBP gene.

<span class="mw-page-title-main">GCM1</span> Protein-coding gene in the species Homo sapiens

Chorion-specific transcription factor GCMa is a protein that, in humans, is encoded by the GCM1 gene.

<span class="mw-page-title-main">Collagen, type V, alpha 3</span> Mammalian protein found in Homo sapiens

Collagen alpha-3(V) chain is a protein that in humans is encoded by the COL5A3 gene.

<span class="mw-page-title-main">TEAD4</span> Protein-coding gene in the species Homo sapiens

Transcriptional enhancer factor TEF-3 is a protein that in humans is encoded by the TEAD4 gene.

<span class="mw-page-title-main">POU2F3</span>

POU domain, class 2, transcription factor 3 is a protein that in humans is encoded by the POU2F3 gene.

<span class="mw-page-title-main">TFAP2C</span> Protein-coding gene in the species Homo sapiens

Transcription factor AP-2 gamma also known as AP2-gamma is a protein that in humans is encoded by the TFAP2C gene. AP2-gamma is a member of the activating protein 2 family of transcription factors.

<span class="mw-page-title-main">NFE2L3</span> Protein-coding gene in the species Homo sapiens

Nuclear factor -like factor 3, also known as NFE2L3 or 'NRF3', is a transcription factor that in humans is encoded by the Nfe2l3 gene.

<span class="mw-page-title-main">Vestigial-like family member 3</span>

Vestigial-like family member 3 is a protein that in humans is encoded by the VGLL3 gene.

The multigenic complex formed by the human growth hormone (hGH) and the human placental lactogen (hPL) takes part in the process of maternal and fetal metabolism regulation and the following growth and development of the fetus.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000007866 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002249 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I (Jan 1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis". Genomics. 55 (1): 127–9. doi:10.1006/geno.1998.5628. hdl: 2268/13836 . PMID   9889009.
  6. ↑ Jacquemin P, Martial JA, Davidson I (May 1997). "Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer". The Journal of Biological Chemistry. 272 (20): 12928–37. doi: 10.1074/jbc.272.20.12928 . PMID   9148898.
  7. 1 2 "Entrez Gene: TEAD3 TEA domain family member 3".
  8. ↑ Bürglin, TR (Jul 1991). "The TEA domain: a novel, highly conserved DNA-binding motif". Cell. 66 (1): 11–12. doi:10.1016/0092-8674(91)90132-I. PMID   2070413. S2CID   2819591.
  9. ↑ Mann CJ, Osborn DP, Hughes SM (Oct 2007). "Vestigial-like-2b (VITO-1b) and Tead-3a (Tef-5a) expression in zebrafish skeletal muscle, brain and notochord". Gene Expression Patterns. 7 (8): 827–36. doi:10.1016/j.modgep.2007.08.001. PMC   3360971 . PMID   17916448.

Further reading


This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.