GTF3C2

GTF3C2
Identifiers
Aliases	GTF3C2 , TFIIIC-BETA, TFIIIC110, general transcription factor IIIC subunit 2
External IDs	OMIM: 604883; MGI: 1919002; HomoloGene: 37490; GeneCards: GTF3C2; OMA:GTF3C2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p23.3 Start 27,325,849 bp [1] End 27,357,034 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 B1 Start 31,313,349 bp [2] End 31,337,488 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg right lobe of thyroid gland right uterine tube skin of abdomen left lobe of thyroid gland minor salivary glands body of pancreas gastric mucosa mucosa of transverse colon granulocyte Top expressed in tail of embryo genital tubercle neural layer of retina yolk sac internal carotid artery external carotid artery epiblast secondary oocyte ventricular zone zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding RNA polymerase III general transcription initiation factor activity Cellular component transcription factor TFIIIC complex nucleus nucleoplasm Biological process tRNA transcription by RNA polymerase III 5S class rRNA transcription by RNA polymerase III transcription, DNA-templated transcription by RNA polymerase III Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2976 71752 Ensembl ENSG00000115207 ENSMUSG00000106864 UniProt Q8WUA4 Q8BL74 RefSeq (mRNA) NM_001035521 NM_001521 NM_001318909 NM_001388380 NM_027901 RefSeq (protein) NP_001030598 NP_001305838 NP_001512 NP_082177 Location (UCSC) Chr 2: 27.33 – 27.36 Mb Chr 5: 31.31 – 31.34 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

General transcription factor 3C polypeptide 2 is a protein that in humans is encoded by the GTF3C2 gene. ^{[5] [6]}

Interactions

GTF3C2 has been shown to interact with GTF3C4 ^[7] and GTF3C5. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000115207 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000106864 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sinn E, Wang Z, Kovelman R, Roeder RG (Jun 1995). "Cloning and characterization of a TFIIIC2 subunit (TFIIIC beta) whose presence correlates with activation of RNA polymerase III-mediated transcription by adenovirus E1A expression and serum factors". Genes Dev. 9 (6): 675–85. doi: 10.1101/gad.9.6.675 . PMID   7729686.
6. "Entrez Gene: GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa".
7. Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (Nov 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC   84812 . PMID   10523658.
8. Hsieh YJ, Wang Z, Kovelman R, Roeder RG (Jul 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC   84305 . PMID   10373544.

Further reading

• Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID   1403646.
• Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi: 10.1093/dnares/1.1.27 . PMID   7584026.
• Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi: 10.1093/dnares/1.1.47 . PMID   7584028.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Chu WM, Wang Z, Roeder RG, Schmid CW (1997). "RNA polymerase III transcription repressed by Rb through its interactions with TFIIIB and TFIIIC2". J. Biol. Chem. 272 (23): 14755–61. doi: 10.1074/jbc.272.23.14755 . PMID   9169441.
• Oettel S, Härtel F, Kober I, Iben S, Seifart KH (1997). "Human transcription factors IIIC2, IIIC1 and a novel component IIIC0 fulfil different aspects of DNA binding to various pol III genes". Nucleic Acids Res. 25 (12): 2440–7. doi:10.1093/nar/25.12.2440. PMC   146769 . PMID   9171097.
• Wang Z, Roeder RG (1998). "DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III". Mol. Cell. 1 (5): 749–57. doi: 10.1016/S1097-2765(00)80074-X . PMID   9660958.
• Hsieh YJ, Wang Z, Kovelman R, Roeder RG (1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC   84305 . PMID   10373544.
• Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC   84812 . PMID   10523658.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Innes F, Ramsbottom B, White RJ (2006). "A test of the model that RNA polymerase III transcription is regulated by selective induction of the 110 kDa subunit of TFIIIC". Nucleic Acids Res. 34 (11): 3399–407. doi:10.1093/nar/gkl432. PMC   1488882 . PMID   16822860.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Dumay-Odelot H, Marck C, Durrieu-Gaillard S, Lefebvre O, Jourdain S, Prochazkova M, Pflieger A, Teichmann M (2007). "Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC". J. Biol. Chem. 282 (23): 17179–89. doi: 10.1074/jbc.M611542200 . PMID   17409385.

External links

• GTF3C2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook TFIIIC-110

This article incorporates text from the United States National Library of Medicine, which is in the public domain.