E4F1

E4F1
Identifiers
Aliases	E4F1 , E4F, E4F transcription factor 1
External IDs	OMIM: 603022 MGI: 109530 HomoloGene: 3259 GeneCards: E4F1
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p13.3 Start 2,223,580 bp [1] End 2,235,742 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17 A3.3|17 12.39 cM Start 24,662,752 bp [2] End 24,689,287 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve right lobe of thyroid gland left lobe of thyroid gland pituitary gland skin of abdomen anterior pituitary blood prostate spleen right lobe of liver Top expressed in lip superior frontal gyrus urethra morula male urethra thymus spermatocyte proximal tubule neural tube cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription corepressor activity DNA-binding transcription factor activity transcription coactivator activity metal ion binding protein binding DNA-binding transcription repressor activity, RNA polymerase II-specific nucleic acid binding cAMP response element binding transferase activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm spindle nucleoplasm nucleus Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated cell division DNA replication regulation of mitotic cell cycle, embryonic protein ubiquitination regulation of growth cell cycle cell population proliferation viral process regulation of cell cycle process positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1877 13560 Ensembl ENSG00000167967 ENSMUSG00000024137 UniProt Q66K89 Q8CCE9 RefSeq (mRNA) NM_001288776 NM_001288778 NM_004424 NM_001301784 NM_007893 NM_001355708 RefSeq (protein) NP_001275705 NP_001275707 NP_004415 NP_001288713 NP_031919 NP_001342637 Location (UCSC) Chr 16: 2.22 – 2.24 Mb Chr 17: 24.66 – 24.69 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transcription factor E4F1 is a protein that in humans is encoded by the E4F1 gene. ^{[5] [6] [7]}

Function

The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. ^[7]

Interactions

E4F1 has been shown to interact with:

• P16, ^[8]
• P53, ^{[8] [9]} and
• RB1 ^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000167967 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024137 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Saccone S, Sandy P, Meroni G, Gostissa M, Della Valle G, Del Sal G (November 1998). "Assignment of the E1A-regulated transcription factor E4F gene (E4F1) to human chromosome band 16p13.3 by in situ hybridization and somatic cell hybrids". Cytogenet Cell Genet. 82 (1–2): 99–100. doi:10.1159/000015075. PMID   9763670. S2CID   46826484.
6. Burn TC, Connors TD, Van Raay TJ, Dackowski WR, Millholland JM, Klinger KW, Landes GM (December 1996). "Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3". Genome Res. 6 (6): 525–537. doi: 10.1101/gr.6.6.525 . PMID   8828041.
7. "Entrez Gene: E4F1 E4F transcription factor 1".
8. Rizos H, Diefenbach E, Badhwar P, Woodruff S, Becker TM, Rooney RJ, Kefford RF (February 2003). "Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition". J. Biol. Chem. 278 (7): 4981–4989. doi: 10.1074/jbc.M210978200 . PMID   12446718.
9. Sandy P, Gostissa M, Fogal V, Cecco LD, Szalay K, Rooney RJ, Schneider C, Del Sal G (January 2000). "p53 is involved in the p120E4F-mediated growth arrest". Oncogene. 19 (2): 188–199. doi: 10.1038/sj.onc.1203250 . PMID   10644996.
10. Fajas L, Paul C, Zugasti O, Le Cam L, Polanowska J, Fabbrizio E, Medema R, Vignais ML, Sardet C (July 2000). "pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7738–7743. Bibcode:2000PNAS...97.7738F. doi: 10.1073/pnas.130198397 . PMC   16614 . PMID   10869426.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Fernandes ER, Rooney RJ (1997). "The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3". Mol. Cell. Biol. 17 (4): 1890–1903. doi:10.1128/mcb.17.4.1890. PMC   232036 . PMID   9121437.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Rooney RJ, Daniels RR, Jenkins NA, Gilbert DJ, Rothammer K, Morris SW, Higgs DR, Copeland NG (1998). "Chromosomal location and tissue expression of the gene encoding the adenovirus E1A-regulated transcription factor E4F in humans and mice". Mamm. Genome. 9 (4): 320–323. doi:10.1007/s003359900758. PMID   9530632. S2CID   31200297.
• Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members". J. Biol. Chem. 274 (53): 37538–37543. doi: 10.1074/jbc.274.53.37538 . PMID   10608806.
• Sandy P, Gostissa M, Fogal V, Cecco LD, Szalay K, Rooney RJ, Schneider C, Del Sal G (2000). "p53 is involved in the p120E4F-mediated growth arrest". Oncogene. 19 (2): 188–199. doi: 10.1038/sj.onc.1203250 . PMID   10644996.
• Fajas L, Paul C, Zugasti O, Le Cam L, Polanowska J, Fabbrizio E, Medema R, Vignais ML, Sardet C (2000). "pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7738–7743. Bibcode:2000PNAS...97.7738F. doi: 10.1073/pnas.130198397 . PMC   16614 . PMID   10869426.
• Rizos H, Diefenbach E, Badhwar P, Woodruff S, Becker TM, Rooney RJ, Kefford RF (2003). "Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition". J. Biol. Chem. 278 (7): 4981–4989. doi: 10.1074/jbc.M210978200 . PMID   12446718.
• Fenton SL, Dallol A, Agathanggelou A, Hesson L, Ahmed-Choudhury J, Baksh S, Sardet C, Dammann R, Minna JD, Downward J, Maher ER, Latif F (2004). "Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene". Cancer Res. 64 (1): 102–107. doi:10.1158/0008-5472.CAN-03-2622. PMID   14729613.
• Nakamura Y, Igarashi K, Suzuki T, Kanno J, Inoue T, Tazawa C, Saruta M, Ando T, Moriyama N, Furukawa T, Ono M, Moriya T, Ito K, Saito H, Ishibashi T, Takahashi S, Yamada S, Sasano H (2005). "E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis". Am. J. Pathol. 165 (6): 2019–2031. doi:10.1016/s0002-9440(10)63253-1. PMC   1618705 . PMID   15579445.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Paul C, Lacroix M, Iankova I, Julien E, Schäfer BW, Labalette C, Wei Y, Le Cam A, Le Cam L, Sardet C (2006). "The LIM-only protein FHL2 is a negative regulator of E4F1". Oncogene. 25 (40): 5475–5484. doi:10.1038/sj.onc.1209567. PMID   16652157.
• Le Cam L, Linares LK, Paul C, Julien E, Lacroix M, Hatchi E, Triboulet R, Bossis G, Shmueli A, Rodriguez MS, Coux O, Sardet C (2006). "E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation". Cell. 127 (4): 775–788. doi: 10.1016/j.cell.2006.09.031 . PMID   17110336. S2CID   542082.
• Cvetanovic M, Rooney RJ, Garcia JJ, Toporovskaya N, Zoghbi HY, Opal P (2007). "The role of LANP and ataxin 1 in E4F-mediated transcriptional repression". EMBO Rep. 8 (7): 671–677. doi:10.1038/sj.embor.7400983. PMC   1905893 . PMID   17557114.

External links

• E4F1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.