SALL3

SALL3
Identifiers
Aliases	SALL3 , ZNF796, spalt-like transcription factor 3, spalt like transcription factor 3
External IDs	OMIM: 605079; MGI: 109295; HomoloGene: 18142; GeneCards: SALL3; OMA:SALL3 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) [1] Band 18q23 Start 78,979,818 bp [1] End 79,002,677 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 E3 Start 81,009,591 bp [2] End 81,029,986 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence amygdala C1 segment caudate nucleus nucleus accumbens putamen hypothalamus substantia nigra testicle Top expressed in Rostral migratory stream tail of embryo Bowman's capsule epiblast ventricular zone genital tubercle primitive streak olfactory bulb perirhinal cortex embryo More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process forelimb morphogenesis neurogenesis regulation of transcription, DNA-templated negative regulation of smoothened signaling pathway transcription by RNA polymerase II olfactory bulb interneuron development hindlimb morphogenesis signal transduction transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27164 20689 Ensembl ENSG00000256463 ENSMUSG00000024565 UniProt Q9BXA9 Q62255 RefSeq (mRNA) NM_171999 NM_178280 NM_001369133 RefSeq (protein) NP_741996 NP_840064 NP_001356062 Location (UCSC) Chr 18: 78.98 – 79 Mb Chr 18: 81.01 – 81.03 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sal-like protein 3, also known as zinc finger protein SALL3, is a protein that in humans in encoded by the SALL3 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000256463 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024565 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: sal-like 3 (Drosophila)".
6. Kohlhase J, Hausmann S, Stojmenovic G, Dixkens C, Bink K, Schulz-Schaeffer W, Altmann M, Engel W (December 1999). "SALL3, a new member of the human spalt-like gene family, maps to 18q23". Genomics. 62 (2): 216–22. doi:10.1006/geno.1999.6005. PMID   10610715.

Further reading

• Sweetman D, Münsterberg A (2006). "The vertebrate spalt genes in development and disease" (PDF). Dev. Biol. 293 (2): 285–93. doi:10.1016/j.ydbio.2006.02.009. PMID   16545361. S2CID   45268563.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Shikauchi Y, Saiura A, Kubo T, et al. (2009). "SALL3 interacts with DNMT3A and shows the ability to inhibit CpG island methylation in hepatocellular carcinoma". Mol. Cell. Biol. 29 (7): 1944–58. doi:10.1128/MCB.00840-08. PMC   2655625 . PMID   19139273.
• Julií A, Ballina J, Caí±ete JD, et al. (2008). "Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility". Arthritis Rheum. 58 (8): 2275–86. doi: 10.1002/art.23623 . hdl: 10553/50124 . PMID   18668548.
• Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell. Proteomics. 7 (3): 499–508. doi: 10.1074/mcp.M700325-MCP200 . PMID   18029348.
• Jugessur A, Shi M, Gjessing HK, et al. (2010). "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia". PLOS ONE. 5 (7): e11493. Bibcode:2010PLoSO...511493J. doi: 10.1371/journal.pone.0011493 . PMC   2901336 . PMID   20634891.
• de Celis JF, Barrio R (2009). "Regulation and function of Spalt proteins during animal development". Int. J. Dev. Biol. 53 (8–10): 1385–98. doi: 10.1387/ijdb.072408jd . hdl: 10261/37592 . PMID   19247946.