NKX2-2

Last updated
NKX2-2
Identifiers
Aliases NKX2-2 , NKX2.2, NKX2B, NK2 homeobox 2
External IDs OMIM: 604612 MGI: 97347 HomoloGene: 1879 GeneCards: NKX2-2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002509

NM_001077632
NM_010919

RefSeq (protein)

NP_002500

NP_001071100
NP_035049

Location (UCSC) Chr 20: 21.51 – 21.51 Mb Chr 2: 147.18 – 147.19 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein Nkx-2.2 is a protein that in humans is encoded by the NKX2-2 gene. [5] [6] [7]

Homeobox protein Nkx-2.2 contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [7]

The expression of Nkx2-2 is regulated by an antisense RNA called Nkx2-2as. [8]

In the developing spinal cord, Nkx-2.2 regulates IRX3 thereby contributing to the proper differentiation of the ventral horn neurons. [9]

Related Research Articles

NEUROD1

Neurogenic differentiation 1 (NeuroD1), also called β2, is a transcription factor of the NeuroD-type. It is encoded by the human gene NEUROD1.

NKX3-1

Homeobox protein Nkx-3.1, also known as NKX3-1, NKX3, BAPX2, NKX3A and NKX3.1 is a protein that in humans is encoded by the NKX3-1 gene located on chromosome 8p. NKX3-1 is a prostatic tumor suppressor gene.

NK2 homeobox 1

NK2 homeobox 1 (NKX2-1), also known as thyroid transcription factor 1 (TTF-1), is a protein which in humans is encoded by the NKX2-1 gene.

Homeobox protein Nkx-2.5

Homeobox protein Nkx-2.5 is a protein that in humans is encoded by the NKX2.5 gene.

Msh homeobox 2

Homeobox protein MSX-2 is a protein that in humans is encoded by the MSX2 gene.

HOXB6

Homeobox protein Hox-B6 is a protein that in humans is encoded by the HOXB6 gene.

<i>CRX</i> (gene)

Cone-rod homeobox protein is a protein that in humans is encoded by the CRX gene.

HOXA5

Homeobox protein Hox-A5 is a protein that in humans is encoded by the HOXA5 gene.

PAX4 Protein-coding gene in humans

Paired box gene 4, also known as PAX4, is a protein which in humans is encoded by the PAX4 gene.

HOXB8

Homeobox protein Hox-B8 is a protein that in humans is encoded by the HOXB8 gene.

ATOH1

Protein atonal homolog 1 is a protein that in humans is encoded by the ATOH1 gene.

EMX2

Homeobox protein Emx2 is a protein that in humans is encoded by the EMX2 gene.

NKX2-3

Homeobox protein Nkx-2.3 is a protein that in humans is encoded by the NKX2-3 gene.

LHX1 Protein-coding gene in the species Homo sapiens

LIM homeobox 1 is a protein that in humans is encoded by the LHX1 gene. This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor important for control of differentiation and development of neural and lymphoid cells. It is also key in development of renal and urogenital systems and is required for normal organogenesis. A similar protein in mice is an essential regulator of the vertebrate head organizer.

Goosecoid protein Protein-coding gene in the species Homo sapiens

Goosecoid (GSC) is a homeobox protein that is coded by the GSC gene. Like other homeobox proteins, goosecoid functions as a transcription factor involved in morphogenesis. In Xenopus, the goosecoid homeobox gene is thought to play a crucial role in the phenomenon of Spemann's Organizer. Through lineage tracing and timelapse microscopy, the effects of GSC on neighboring cell fates could be observed. In an experiment that injected cells with GSC and observed the effects of un-injected cells, GSC recruited neighboring uninjected cells in the dorsal blastopore lip of the Xenopus gastrula to form a twinned dorsal axis, suggesting that the Goosecoid protein plays a role in the regulation and migration of cells during gastrulation. However, it is not yet fully understood how GSC conducts this organizational function. Errors in the formation of goosecoid protein in mice and humans have a range of consequences on the developing embryo typically in regions of neuro crest cell derivatives, the hip and shoulder joints, and craniofacial development. Short stature, auditory canal atresia, mandibular hypoplasia, and skeletal abnormalities (SAMS) was thought to be a rare autosomal recessive developmental disorder, but through whole-exome sequencing, it was discovered that SAMS is the result of a mutation of the GSC gene. The data collected from the whole-exome sequencing, as well as the phenotypical presentation of SAMS, indicates that in mammals, the goosecoid protein is involved with the regulation and migration of neuro crest cell fates and other mesodermal patterning, notably joints like the shoulders and hips.

NKX3-2

NK3 homeobox 2 also known as NKX3-2 is a human gene. It is a homolog of bagpipe (bap) in Drosophila and therefore also known as Bapx1. The protein encoded by this gene is a homeodomain containing transcription factor.

NKX6-1

Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene.

DBX1

Homeobox protein DBX1, also known as developing brain homeobox protein 1, is a protein that in humans is encoded by the DBX1 gene. The DBX1 gene is a transcription factor gene that is pivotal in interneuron differentiation in the ventral spinal cord.

IRX3

Iroquois-class homeodomain protein IRX-3, also known as Iroquois homeobox protein 3, is a protein that in humans is encoded by the IRX3 gene.

PKNOX2

PBX/Knotted 1 Homeobox 2 (PKNOX2) protein belongs to the three amino acid loop extension (TALE) class of homeodomain proteins, and is encoded by PKNOX2 gene in humans. The protein regulates the transcription of other genes and affects anatomical development.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000125820 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027434 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Furuta H, Horikawa Y, Iwasaki N, Hara M, Sussel L, Le Beau MM, Davis EM, Ogata M, Iwamoto Y, German MS, Bell GI (Aug 1998). "Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese". Diabetes. 47 (8): 1356–1358. doi:10.2337/diabetes.47.8.1356. PMID   9703340.
  6. Price M, Lazzaro D, Pohl T, Mattei MG, Rüther U, Olivo JC, Duboule D, Di Lauro R (Feb 1992). "Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain". Neuron. 8 (2): 241–255. doi:10.1016/0896-6273(92)90291-K. PMID   1346742. S2CID   22766848.
  7. 1 2 "Entrez Gene: NKX2-2 NK2 transcription factor related, locus 2 (Drosophila)".
  8. Tochitani S, Hayashizaki Y (Aug 2008). "Nkx2.2 antisense RNA overexpression enhanced oligodendrocytic differentiation". Biochemical and Biophysical Research Communications. 372 (4): 691–696. doi:10.1016/j.bbrc.2008.05.127. PMID   18538132.
  9. Lovrics A, Gao Y, Juhász B, Bock I, Byrne HM, Dinnyés A, Kovács KA (November 2014). "Boolean modelling reveals new regulatory connections between transcription factors orchestrating the development of the ventral spinal cord". PLOS ONE. 9 (11): e111430. Bibcode:2014PLoSO...9k1430L. doi:10.1371/journal.pone.0111430. PMC   4232242 . PMID   25398016.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.