Neurogenic differentiation 1 (NeuroD1), also called β2, is a transcription factor of the NeuroD-type. It is encoded by the human gene NEUROD1.
Homeobox protein Nkx-3.1, also known as NKX3-1, NKX3, BAPX2, NKX3A and NKX3.1 is a protein that in humans is encoded by the NKX3-1 gene located on chromosome 8p. NKX3-1 is a prostatic tumor suppressor gene.
NK2 homeobox 1 (NKX2-1), also known as thyroid transcription factor 1 (TTF-1), is a protein which in humans is encoded by the NKX2-1 gene.
Homeobox protein Nkx-2.5 is a protein that in humans is encoded by the NKX2.5 gene.
Homeobox protein MSX-2 is a protein that in humans is encoded by the MSX2 gene.
Homeobox protein Hox-B6 is a protein that in humans is encoded by the HOXB6 gene.
Cone-rod homeobox protein is a protein that in humans is encoded by the CRX gene.
Homeobox protein Hox-A5 is a protein that in humans is encoded by the HOXA5 gene.
Paired box gene 4, also known as PAX4, is a protein which in humans is encoded by the PAX4 gene.
Homeobox protein Hox-B8 is a protein that in humans is encoded by the HOXB8 gene.
Protein atonal homolog 1 is a protein that in humans is encoded by the ATOH1 gene.
Homeobox protein Emx2 is a protein that in humans is encoded by the EMX2 gene.
Homeobox protein Nkx-2.3 is a protein that in humans is encoded by the NKX2-3 gene.
LIM homeobox 1 is a protein that in humans is encoded by the LHX1 gene. This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor important for control of differentiation and development of neural and lymphoid cells. It is also key in development of renal and urogenital systems and is required for normal organogenesis. A similar protein in mice is an essential regulator of the vertebrate head organizer.
Goosecoid (GSC) is a homeobox protein that is coded by the GSC gene. Like other homeobox proteins, goosecoid functions as a transcription factor involved in morphogenesis. In Xenopus, the goosecoid homeobox gene is thought to play a crucial role in the phenomenon of Spemann's Organizer. Through lineage tracing and timelapse microscopy, the effects of GSC on neighboring cell fates could be observed. In an experiment that injected cells with GSC and observed the effects of un-injected cells, GSC recruited neighboring uninjected cells in the dorsal blastopore lip of the Xenopus gastrula to form a twinned dorsal axis, suggesting that the Goosecoid protein plays a role in the regulation and migration of cells during gastrulation. However, it is not yet fully understood how GSC conducts this organizational function. Errors in the formation of goosecoid protein in mice and humans have a range of consequences on the developing embryo typically in regions of neuro crest cell derivatives, the hip and shoulder joints, and craniofacial development. Short stature, auditory canal atresia, mandibular hypoplasia, and skeletal abnormalities (SAMS) was thought to be a rare autosomal recessive developmental disorder, but through whole-exome sequencing, it was discovered that SAMS is the result of a mutation of the GSC gene. The data collected from the whole-exome sequencing, as well as the phenotypical presentation of SAMS, indicates that in mammals, the goosecoid protein is involved with the regulation and migration of neuro crest cell fates and other mesodermal patterning, notably joints like the shoulders and hips.
NK3 homeobox 2 also known as NKX3-2 is a human gene. It is a homolog of bagpipe (bap) in Drosophila and therefore also known as Bapx1. The protein encoded by this gene is a homeodomain containing transcription factor.
Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene.
Homeobox protein DBX1, also known as developing brain homeobox protein 1, is a protein that in humans is encoded by the DBX1 gene. The DBX1 gene is a transcription factor gene that is pivotal in interneuron differentiation in the ventral spinal cord.
Iroquois-class homeodomain protein IRX-3, also known as Iroquois homeobox protein 3, is a protein that in humans is encoded by the IRX3 gene.
PBX/Knotted 1 Homeobox 2 (PKNOX2) protein belongs to the three amino acid loop extension (TALE) class of homeodomain proteins, and is encoded by PKNOX2 gene in humans. The protein regulates the transcription of other genes and affects anatomical development.
