FOXN3

FOXN3
Identifiers
Aliases	FOXN3 , C14orf116, CHES1, PRO1635, forkhead box N3
External IDs	OMIM: 602628; MGI: 1918625; HomoloGene: 3809; GeneCards: FOXN3; OMA:FOXN3 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q31.3-q32.11 Start 89,124,871 bp [1] End 89,619,149 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 E Start 99,156,337 bp [2] End 99,529,841 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in paraflocculus of cerebellum tendon of biceps brachii nipple saphenous vein skin of hip skin of arm mucosa of paranasal sinus skin of thigh synovial joint Skeletal muscle tissue of rectus abdominis Top expressed in zygote secondary oocyte hand ascending aorta soleus muscle Rostral migratory stream tibialis anterior muscle foot gastrocnemius muscle aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein C-terminus binding protein binding DNA-binding transcription factor activity sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process cell cycle mitotic G2 DNA damage checkpoint signaling negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated craniofacial suture morphogenesis cell differentiation positive regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1112 71375 Ensembl ENSG00000053254 ENSMUSG00000033713 UniProt O00409 Q499D0 RefSeq (mRNA) NM_005197 NM_001085471 NM_183186 RefSeq (protein) NP_001078940 NP_005188 NP_899009 Location (UCSC) Chr 14: 89.12 – 89.62 Mb Chr 12: 99.16 – 99.53 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Forkhead box protein N3 is a protein that in humans is encoded by the FOXN3 gene. ^{[5] [6]}

This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms. ^[6]

See also

• FOX proteins

References

1. GRCh38: Ensembl release 89: ENSG00000053254 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033713 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pati D, Keller C, Groudine M, Plon SE (Jun 1997). "Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA". Mol Cell Biol. 17 (6): 3037–46. doi:10.1128/MCB.17.6.3037. PMC   232156 . PMID   9154802.
6. "Entrez Gene: CHES1 checkpoint suppressor 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Field LL, Tobias R, Thomson G, Plon S (1996). "Susceptibility to insulin-dependent diabetes mellitus maps to a locus (IDDM11) on human chromosome 14q24.3-q31". Genomics. 33 (1): 1–8. doi:10.1006/geno.1996.0153. PMID   8617492.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi: 10.1101/gr.6.9.807 . PMID   8889549.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Yu Y, Zhang C, Zhou G, et al. (2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs". Genome Res. 11 (8): 1392–403. doi:10.1101/gr.175501. PMC   311073 . PMID   11483580.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. Bibcode:2003Natur.421..601H. doi: 10.1038/nature01348 . PMID   12508121.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Scott KL, Plon SE (2005). "CHES1/FOXN3 interacts with Ski-interacting protein and acts as a transcriptional repressor". Gene. 359: 119–26. doi:10.1016/j.gene.2005.06.014. PMID   16102918.
• Busygina V, Kottemann MC, Scott KL, et al. (2007). "Multiple endocrine neoplasia type 1 interacts with forkhead transcription factor CHES1 in DNA damage response". Cancer Res. 66 (17): 8397–403. doi: 10.1158/0008-5472.CAN-06-0061 . PMID   16951149.
• Katoh H, Ojima H, Kokubu A, et al. (2007). "Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets". Gastroenterology. 133 (5): 1475–86. doi: 10.1053/j.gastro.2007.08.038 . PMID   17983802.

External links

• CHES1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)