JUNB

Last updated
JUNB
Identifiers
Aliases JUNB , AP-1, JunB proto-oncogene, AP-1 transcription factor subunit
External IDs OMIM: 165161; MGI: 96647; HomoloGene: 7390; GeneCards: JUNB; OMA:JUNB - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002229

NM_008416

RefSeq (protein)

NP_002220

NP_032442

Location (UCSC) Chr 19: 12.79 – 12.79 Mb Chr 8: 85.7 – 85.71 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transcription factor jun-B is a protein that, in humans, is encoded by the JUNB gene. [5] [6] Transcription factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'.

Contents

Interactions

JUNB has been shown to interact with

See also

Related Research Articles

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<span class="mw-page-title-main">FOSB</span> Protein

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Basic leucine zipper transcription factor, ATF-like, also known as BATF, is a protein which in humans is encoded by the BATF gene.

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000171223 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052837 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Schütte J, Viallet J, Nau M, Segal S, Fedorko J, Minna J (Feb 1990). "jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun". Cell. 59 (6): 987–997. doi: 10.1016/0092-8674(89)90755-1 . PMID   2513129.
  6. "Entrez Gene: JUNB jun B proto-oncogene".
  7. Hu YF, Li R (Jun 2002). "JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction". Genes Dev. 16 (12): 1509–17. doi:10.1101/gad.995502. PMC   186344 . PMID   12080089.
  8. Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman EM, Wang XF (Apr 1999). "Smads bind directly to the Jun family of AP-1 transcription factors". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 4844–9. Bibcode:1999PNAS...96.4844L. doi: 10.1073/pnas.96.9.4844 . PMC   21779 . PMID   10220381.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.