JUNB

JUNB
Identifiers
Aliases	JUNB , AP-1, JunB proto-oncogene, AP-1 transcription factor subunit
External IDs	OMIM: 165161; MGI: 96647; HomoloGene: 7390; GeneCards: JUNB; OMA:JUNB - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.13 Start 12,791,486 bp [1] End 12,793,315 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8 C3|8 41.41 cM Start 85,701,113 bp [2] End 85,705,347 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa left uterine tube granulocyte monocyte tibial arteries vena cava saphenous vein left ovary nipple trachea Top expressed in granulocyte lip superior surface of tongue spermatid spermatocyte corneal stroma visual cortex esophagus transitional epithelium of urinary bladder primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription corepressor activity DNA-binding transcription factor activity transcription coactivator activity DNA-binding transcription activator activity, RNA polymerase II-specific transcription factor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleoplasm chromatin nucleus transcription factor AP-1 complex transcription regulator complex Biological process cellular response to calcium ion regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II regulation of cell death osteoclast differentiation labyrinthine layer blood vessel development in utero embryonic development negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II regulation of cell cycle vasculogenesis embryonic process involved in female pregnancy response to lipopolysaccharide decidualization regulation of cell population proliferation trophectodermal cell differentiation osteoblast differentiation positive regulation of cell differentiation response to radiation osteoblast proliferation cellular process or phenomenon response to cAMP response to mechanical stimulus transcription, DNA-templated cellular response to hormone stimulus response to cytokine positive regulation of transcription by RNA polymerase II cytokine-mediated signaling pathway response to organic substance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3726 16477 Ensembl ENSG00000171223 ENSMUSG00000052837 UniProt P17275 P09450 RefSeq (mRNA) NM_002229 NM_008416 RefSeq (protein) NP_002220 NP_032442 Location (UCSC) Chr 19: 12.79 – 12.79 Mb Chr 8: 85.7 – 85.71 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transcription factor jun-B is a protein that, in humans, is encoded by the JUNB gene. ^{[5] [6]} Transcription factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'.

Interactions

JUNB has been shown to interact with

• BRCA1, ^[7] and
• SMAD3. ^[8]

See also

• AP-1 (transcription factor)

References

1. GRCh38: Ensembl release 89: ENSG00000171223 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052837 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schütte J, Viallet J, Nau M, Segal S, Fedorko J, Minna J (Feb 1990). "jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun". Cell. 59 (6): 987–997. doi: 10.1016/0092-8674(89)90755-1 . PMID   2513129.
6. "Entrez Gene: JUNB jun B proto-oncogene".
7. Hu YF, Li R (Jun 2002). "JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction". Genes Dev. 16 (12): 1509–17. doi:10.1101/gad.995502. PMC   186344 . PMID   12080089.
8. Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman EM, Wang XF (Apr 1999). "Smads bind directly to the Jun family of AP-1 transcription factors". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 4844–9. Bibcode:1999PNAS...96.4844L. doi: 10.1073/pnas.96.9.4844 . PMC   21779 . PMID   10220381.

Further reading

• Hsu JC, Bravo R, Taub R (1992). "Interactions among LRF-1, JunB, c-Jun, and c-Fos define a regulatory program in the G1 phase of liver regeneration". Mol. Cell. Biol. 12 (10): 4654–65. doi:10.1128/MCB.12.10.4654. PMC   360392 . PMID   1406655.
• Zafarullah M, Martel-Pelletier J, Cloutier JM, Gedamu L, Pelletier JP (1992). "Expression of c-fos, c-jun, jun-B, metallothionein and metalloproteinase genes in human chondrocyte". FEBS Lett. 306 (2–3): 169–172. Bibcode:1992FEBSL.306..169Z. doi: 10.1016/0014-5793(92)80992-P . PMID   1633872. S2CID   43460076.
• Mollinedo F, Vaquerizo MJ, Naranjo JR (1991). "Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes". Biochem. J. 273(Pt 2) (2): 477–9. doi:10.1042/bj2730477. PMC   1149869 . PMID   1899335.
• Nomura N, Ide M, Sasamoto S, Matsui M, Date T, Ishizaki R (1990). "Isolation of human cDNA clones of jun-related genes, jun-B and jun-D". Nucleic Acids Res. 18 (10): 3047–3048. doi:10.1093/nar/18.10.3047. PMC   330838 . PMID   2112242.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, de Jong P, Mohrenweiser H, Olsen A, Carrano A (1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers". Genomics. 15 (1): 133–145. doi:10.1006/geno.1993.1021. PMID   8432525.
• Phinney DG, Tseng SW, Ryder K (1996). "Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci". Genomics. 28 (2): 228–234. doi:10.1006/geno.1995.1135. PMID   8530030.
• Dorsey MJ, Tae HJ, Sollenberger KG, Mascarenhas NT, Johansen LM, Taparowsky EJ (1996). "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family". Oncogene. 11 (11): 2255–65. PMID   8570175.
• Neyns B, Vermeij J, Bourgain C, Vandamme B, Amfo K, Lissens W, DeSutter P, Hooghe-Peters E, DeGrève J (1996). "Expression of the jun family of genes in human ovarian cancer and normal ovarian surface epithelium". Oncogene. 12 (6): 1247–57. PMID   8649827.
• Mendelson KG, Contois LR, Tevosian SG, Davis RJ, Paulson KE (1996). "Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver". Proc. Natl. Acad. Sci. U.S.A. 93 (23): 12908–12913. Bibcode:1996PNAS...9312908M. doi: 10.1073/pnas.93.23.12908 . PMC   24019 . PMID   8917518.
• Aronheim A, Zandi E, Hennemann H, Elledge SJ, Karin M (1997). "Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions". Mol. Cell. Biol. 17 (6): 3094–102. doi:10.1128/mcb.17.6.3094. PMC   232162 . PMID   9154808.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Fuchs SY, Xie B, Adler V, Fried VA, Davis RJ, Ronai Z (1998). "c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors". J. Biol. Chem. 272 (51): 32163–32168. doi: 10.1074/jbc.272.51.32163 . PMID   9405416.
• Venugopal R, Jaiswal AK (1999). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes". Oncogene. 17 (24): 3145–3156. doi: 10.1038/sj.onc.1202237 . PMID   9872330.
• Li B, Tournier C, Davis RJ, Flavell RA (1999). "Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation". EMBO J. 18 (2): 420–432. doi:10.1093/emboj/18.2.420. PMC   1171136 . PMID   9889198.
• Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman EM, Wang XF (1999). "Smads bind directly to the Jun family of AP-1 transcription factors". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 4844–4849. Bibcode:1999PNAS...96.4844L. doi: 10.1073/pnas.96.9.4844 . PMC   21779 . PMID   10220381.
• Chen P, Flory E, Avots A, Jordan BW, Kirchhoff F, Ludwig S, Rapp UR (2000). "Transactivation of naturally occurring HIV-1 long terminal repeats by the JNK signaling pathway. The most frequent naturally occurring length polymorphism sequence introduces a novel binding site for AP-1 factors". J. Biol. Chem. 275 (27): 20382–20390. doi: 10.1074/jbc.M001149200 . PMID   10764760.
• Echlin DR, Tae HJ, Mitin N, Taparowsky EJ (2000). "B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos". Oncogene. 19 (14): 1752–1763. doi: 10.1038/sj.onc.1203491 . PMID   10777209.
• Verrecchia F, Pessah M, Atfi A, Mauviel A (2000). "Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation". J. Biol. Chem. 275 (39): 30226–30231. doi: 10.1074/jbc.M005310200 . PMID   10903323.
• Singh K, Camera E, Krug L, Basu A, Pandey RK, Munir S, Wlaschek M, Kochanek S, Schorpp-Kistner M, Picardo M, Angel P, Niemann C, Maity P, Scharffetter-Kochanek K (2018). "JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin". Nature. 9 (1) 3425. Bibcode:2018NatCo...9.3425S. doi: 10.1038/s41467-018-05726-z . PMC   6109099 . PMID   30143626.

External links

• JUNB+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.