HBP1

HBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E6O, 3QVE
Identifiers
Aliases	HBP1 , HMG-box transcription factor 1
External IDs	OMIM: 616714 MGI: 894659 HomoloGene: 8171 GeneCards: HBP1
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q22.3 Start 107,168,961 bp [1] End 107,202,522 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 A3 Start 31,976,253 bp [2] End 32,000,534 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon right lung skin of abdomen bone marrow cells gastric mucosa gastrocnemius muscle canal of the cervix minor salivary gland gallbladder stromal cell of endometrium Top expressed in interventricular septum carotid body lacrimal gland belly cord ovary conjunctival fornix left lung lobe seminal vesicula hair follicle vastus lateralis muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding RNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm nuclear speck Biological process regulation of transcription, DNA-templated Wnt signaling pathway transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26959 73389 Ensembl ENSG00000105856 ENSG00000283847 ENSMUSG00000002996 UniProt O60381 Q8R316 RefSeq (mRNA) NM_001244262 NM_012257 NM_153198 NM_177993 NM_001361928 RefSeq (protein) NP_001231191 NP_036389 NP_694878 NP_818774 NP_001348857 Location (UCSC) Chr 7: 107.17 – 107.2 Mb Chr 12: 31.98 – 32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

HMG-box transcription factor 1, also known as HBP1, is a human protein. ^[5]

Interactions

HBP1 has been shown to interact with SIN3A ^[6] and Retinoblastoma protein. ^[7]

References

1. ENSG00000283847 GRCh38: Ensembl release 89: ENSG00000105856, ENSG00000283847 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002996 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: HBP1 HMG-box transcription factor 1".
6. Swanson KA, Knoepfler Paul S, Huang Kai, Kang Richard S, Cowley Shaun M, Laherty Carol D, Eisenman Robert N, Radhakrishnan Ishwar (Aug 2004). "HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations". Nat. Struct. Mol. Biol. 11 (8): 738–46. doi:10.1038/nsmb798. ISSN   1545-9993. PMID   15235594. S2CID   44324333.
7. Lavender P, Vandel L, Bannister A J, Kouzarides T (Jun 1997). "The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A". Oncogene. 14 (22): 2721–8. doi: 10.1038/sj.onc.1201243 . ISSN   0950-9232. PMID   9178770.

Further reading

• Tevosian SG, Shih HH, Mendelson KG, et al. (1997). "HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family". Genes Dev. 11 (3): 383–96. doi: 10.1101/gad.11.3.383 . PMID   9030690.
• Lavender P, Vandel L, Bannister AJ, Kouzarides T (1997). "The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A". Oncogene. 14 (22): 2721–8. doi: 10.1038/sj.onc.1201243 . PMID   9178770.
• Zhuma T, Tyrrell R, Sekkali B, et al. (2000). "Human HMG box transcription factor HBP1: a role in hCD2 LCR function". EMBO J. 18 (22): 6396–406. doi:10.1093/emboj/18.22.6396. PMC   1171702 . PMID   10562551.
• Lemercier C, Duncliffe K, Boibessot I, et al. (2000). "Involvement of Retinoblastoma Protein and HBP1 in Histone H10 Gene Expression". Mol. Cell. Biol. 20 (18): 6627–37. doi:10.1128/MCB.20.18.6627-6637.2000. PMC   86159 . PMID   10958660.
• Shih HH, Xiu M, Berasi SP, et al. (2001). "HMG Box Transcriptional Repressor HBP1 Maintains a Proliferation Barrier in Differentiated Liver Tissue". Mol. Cell. Biol. 21 (17): 5723–32. doi:10.1128/MCB.21.17.5723-5732.2001. PMC   87292 . PMID   11486012.
• Sampson EM, Haque ZK, Ku MC, et al. (2001). "Negative regulation of the Wnt–β-catenin pathway by the transcriptional repressor HBP1". EMBO J. 20 (16): 4500–11. doi:10.1093/emboj/20.16.4500. PMC   125566 . PMID   11500377.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID   12853948.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• de Chiara C, Kelly G, Frenkiel TA, Pastore A (2004). "Assignment of the 1H, 13C, and 15N resonances of the AXH domain of the transcription factor HBP1". J. Biomol. NMR. 28 (4): 411–2. doi:10.1023/B:JNMR.0000015367.92295.0f. PMID   14872137. S2CID   43367627.
• Berasi SP, Xiu M, Yee AS, Paulson KE (2004). "HBP1 Repression of the p47phox Gene: Cell Cycle Regulation via the NADPH Oxidase". Mol. Cell. Biol. 24 (7): 3011–24. doi:10.1128/MCB.24.7.3011-3024.2004. PMC   371097 . PMID   15024088.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Swanson KA, Knoepfler PS, Huang K, et al. (2004). "HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations". Nat. Struct. Mol. Biol. 11 (8): 738–46. doi:10.1038/nsmb798. PMID   15235594. S2CID   44324333.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Yao CJ, Works K, Romagnoli PA, Austin GE (2005). "Effects of overexpression of HBP1 upon growth and differentiation of leukemic myeloid cells". Leukemia. 19 (11): 1958–68. doi:10.1038/sj.leu.2403918. PMID   16179914. S2CID   10030062.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Sekkali B, Szabat E, Ktistaki E, et al. (2005). "Human high mobility group box transcription factor 1 affects thymocyte development and transgene variegation". J. Immunol. 175 (8): 5203–12. doi: 10.4049/jimmunol.175.8.5203 . PMID   16210625.
• Kim J, Zhang X, Rieger-Christ KM, et al. (2006). "Suppression of Wnt signaling by the green tea compound (-)-epigallocatechin 3-gallate (EGCG) in invasive breast cancer cells. Requirement of the transcriptional repressor HBP1". J. Biol. Chem. 281 (16): 10865–75. doi: 10.1074/jbc.M513378200 . PMID   16495219.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein–protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.
• Zhang X, Kim J, Ruthazer R, et al. (2007). "The HBP1 Transcriptional Repressor Participates in RAS-Induced Premature Senescence". Mol. Cell. Biol. 26 (22): 8252–66. doi:10.1128/MCB.00604-06. PMC   1636767 . PMID   16966377.

External links

• HBP1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)