EGR4

EGR4
Identifiers
Aliases	EGR4 , NGFI-C, NGFIC, PAT133, early growth response 4, Early growth response protein 4, AT133
External IDs	OMIM: 128992; MGI: 99252; HomoloGene: 1485; GeneCards: EGR4; OMA:EGR4 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p13.2 Start 73,290,929 bp [1] End 73,293,701 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6 C3|6 37.48 cM Start 85,488,103 bp [2] End 85,490,571 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in beta cell gonad Region I of hippocampus proper endothelial cell testicle pancreatic ductal cell putamen Brodmann area 46 nucleus accumbens entorhinal cortex Top expressed in superior frontal gyrus primary visual cortex urethra female urethra male urethra embryo dentate gyrus of hippocampal formation granule cell spermatocyte cerebellar cortex hippocampus proper More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding metal ion binding nucleic acid binding DNA-binding transcription activator activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding Cellular component nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of cell population proliferation transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II cellular response to growth factor stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1961 13656 Ensembl ENSG00000135625 ENSMUSG00000071341 UniProt Q05215 Q9WUF2 RefSeq (mRNA) NM_001965 NM_020596 RefSeq (protein) NP_001956 NP_065621 Location (UCSC) Chr 2: 73.29 – 73.29 Mb Chr 6: 85.49 – 85.49 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Early growth response protein 4 (EGR-4), also known as AT133, is a protein that in humans is encoded by the EGR4 gene. ^[5]

EGR-4 is a member of the early growth response (EGF) family of zinc finger transcription factors.

References

1. GRCh38: Ensembl release 89: ENSG00000135625 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000071341 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: early growth response 4".

Further reading

• Crosby SD, Veile RA, Donis-Keller H, et al. (1992). "Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C". Proc. Natl. Acad. Sci. U.S.A. 89 (10): 4739–43. Bibcode:1992PNAS...89.4739C. doi: 10.1073/pnas.89.10.4739 . PMC   49159 . PMID   1584812.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID   15815621.
• Müller HJ, Skerka C, Bialonski A, Zipfel PF (November 1991). "Clone pAT 133 identifies a gene that encodes another human member of a class of growth factor-induced genes with almost identical zinc-finger domains". Proc. Natl. Acad. Sci. U.S.A. 88 (22): 10079–83. Bibcode:1991PNAS...8810079M. doi: 10.1073/pnas.88.22.10079 . PMC   52871 . PMID   1658795.
• Decker EL, Nehmann N, Kampen E, et al. (2003). "Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression". Nucleic Acids Res. 31 (3): 911–21. doi:10.1093/nar/gkg186. PMC   149206 . PMID   12560487.
• Liu BC, Zhang J, Wang L, et al. (2010). "No association between EGR gene family polymorphisms and schizophrenia in the Chinese population". Prog. Neuropsychopharmacol. Biol. Psychiatry. 34 (3): 506–9. doi:10.1016/j.pnpbp.2010.02.005. PMID   20144677. S2CID   207409159.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Holst C, Skerka C, Lichter P, et al. (1993). "Genomic organization, chromosomal localization and promoter function of the human zinc-finger gene pAT133". Hum. Mol. Genet. 2 (4): 367–72. doi:10.1093/hmg/2.4.367. PMID   8504297.
• Crosby SD, Puetz JJ, Simburger KS, et al. (1991). "The early response gene NGFI-C encodes a zinc finger transcriptional activator and is a member of the GCGGGGGCG (GSG) element-binding protein family". Mol. Cell. Biol. 11 (8): 3835–41. doi:10.1128/MCB.11.8.3835. PMC   361165 . PMID   2072895.
• Hadziselimovic F, Hadziselimovic NO, Demougin P, et al. (2009). "EGR4 is a master gene responsible for fertility in cryptorchidism". Sex Dev. 3 (5): 253–63. doi: 10.1159/000249147 . PMID   19828938.