MEIS1

MEIS1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4XRS
Identifiers
Aliases	MEIS1 , Meis homeobox 1
External IDs	OMIM: 601739 HomoloGene: 135741 GeneCards: MEIS1
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p14 Start 66,433,452 bp [1] End 66,573,869 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube gastric mucosa canal of the cervix left uterine tube stromal cell of endometrium palpebral conjunctiva Right adrenal gland myometrium body of pancreas vagina n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific chromatin binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding protein heterodimerization activity transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding Cellular component transcription regulator complex nucleus Biological process megakaryocyte development regulation of transcription, DNA-templated blood vessel morphogenesis negative regulation of neuron differentiation locomotory behavior transcription by RNA polymerase II transcription, DNA-templated multicellular organism development lens morphogenesis in camera-type eye angiogenesis definitive hemopoiesis negative regulation of myeloid cell differentiation positive regulation of transcription by RNA polymerase II negative regulation of cardiac muscle cell proliferation hemopoiesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4211 n/a Ensembl ENSG00000143995 n/a UniProt O00470 n/a RefSeq (mRNA) NM_002398 n/a RefSeq (protein) NP_002389 n/a Location (UCSC) Chr 2: 66.43 – 66.57 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Homeobox protein Meis1 is a protein that in humans is encoded by the MEIS1 gene. ^{[3] [4]}

Function

Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. ^[4]

Interactions

MEIS1 has been shown to interact with PBX1 ^{[5] [6] [7]} and HOXA9. ^{[5] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000143995 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Moskow JJ, Bullrich F, Huebner K, Daar IO, Buchberg AM (Oct 1995). "Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice". Molecular and Cellular Biology. 15 (10): 5434–43. doi:10.1128/mcb.15.10.5434. PMC   230793 . PMID   7565694.
4. "Entrez Gene: MEIS1 Meis homeobox 1".
5. Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (Apr 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology. 19 (4): 3051–61. doi:10.1128/mcb.19.4.3051. PMC   84099 . PMID   10082572.
6. Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS (Nov 1999). "PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins". Molecular and Cellular Biology. 19 (11): 7577–88. doi:10.1128/mcb.19.11.7577. PMC   84774 . PMID   10523646.
7. Jacobs Y, Schnabel CA, Cleary ML (Jul 1999). "Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity". Molecular and Cellular Biology. 19 (7): 5134–42. doi:10.1128/mcb.19.7.5134. PMC   84356 . PMID   10373562.
8. Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM, Largman C (Nov 1997). "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins". Molecular and Cellular Biology. 17 (11): 6448–58. doi:10.1128/MCB.17.11.6448. PMC   232497 . PMID   9343407.

Further reading

• Allen TD, Zhu YX, Hawley TS, Hawley RG (Oct 2000). "TALE homeoproteins as HOX11-interacting partners in T-cell leukemia". Leukemia & Lymphoma. 39 (3–4): 241–56. doi:10.3109/10428190009065824. PMID   11342305. S2CID   27407074.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Steelman S, Moskow JJ, Muzynski K, North C, Druck T, Montgomery JC, Huebner K, Daar IO, Buchberg AM (Feb 1997). "Identification of a conserved family of Meis1-related homeobox genes". Genome Research. 7 (2): 142–56. doi: 10.1101/gr.7.2.142 . PMID   9049632.
• Smith JE, Bollekens JA, Inghirami G, Takeshita K (Jul 1997). "Cloning and mapping of the MEIS1 gene, the human homolog of a murine leukemogenic gene". Genomics. 43 (1): 99–103. doi: 10.1006/geno.1997.4766 . PMID   9226379.
• Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM, Largman C (Nov 1997). "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins". Molecular and Cellular Biology. 17 (11): 6448–58. doi:10.1128/MCB.17.11.6448. PMC   232497 . PMID   9343407.
• Knoepfler PS, Calvo KR, Chen H, Antonarakis SE, Kamps MP (Dec 1997). "Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1". Proceedings of the National Academy of Sciences of the United States of America. 94 (26): 14553–8. Bibcode:1997PNAS...9414553K. doi: 10.1073/pnas.94.26.14553 . PMC   25052 . PMID   9405651.
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (Nov 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID   9847074.
• Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (Apr 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology. 19 (4): 3051–61. doi:10.1128/MCB.19.4.3051. PMC   84099 . PMID   10082572.
• Jacobs Y, Schnabel CA, Cleary ML (Jul 1999). "Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity". Molecular and Cellular Biology. 19 (7): 5134–42. doi:10.1128/MCB.19.7.5134. PMC   84356 . PMID   10373562.
• Knoepfler PS, Bergstrom DA, Uetsuki T, Dac-Korytko I, Sun YH, Wright WE, Tapscott SJ, Kamps MP (Sep 1999). "A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1". Nucleic Acids Research. 27 (18): 3752–61. doi:10.1093/nar/27.18.3752. PMC   148632 . PMID   10471746.
• Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS (Nov 1999). "PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins". Molecular and Cellular Biology. 19 (11): 7577–88. doi:10.1128/MCB.19.11.7577. PMC   84774 . PMID   10523646.
• Spieker N, van Sluis P, Beitsma M, Boon K, van Schaik BD, van Kampen AH, Caron H, Versteeg R (Jan 2001). "The MEIS1 oncogene is highly expressed in neuroblastoma and amplified in cell line IMR32". Genomics. 71 (2): 214–21. doi:10.1006/geno.2000.6408. PMID   11161815.
• Wang Y, Yin L, Hillgartner FB (Jun 2001). "The homeodomain proteins PBX and MEIS1 are accessory factors that enhance thyroid hormone regulation of the malic enzyme gene in hepatocytes". The Journal of Biological Chemistry. 276 (26): 23838–48. doi: 10.1074/jbc.M102166200 . PMID   11331288.
• Okada Y, Nagai R, Sato T, Matsuura E, Minami T, Morita I, Doi T (Jun 2003). "Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene". Blood. 101 (12): 4748–56. doi: 10.1182/blood-2002-02-0380 . PMID   12609849. S2CID   6532721.
• Zeisig BB, Milne T, García-Cuéllar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK (Jan 2004). "Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization". Molecular and Cellular Biology. 24 (2): 617–28. doi:10.1128/MCB.24.2.617-628.2004. PMC   343796 . PMID   14701735.
• Pineault N, Abramovich C, Ohta H, Humphries RK (Mar 2004). "Differential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1". Molecular and Cellular Biology. 24 (5): 1907–17. doi:10.1128/MCB.24.5.1907-1917.2004. PMC   350554 . PMID   14966272.

External links

• MEIS1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.