HOXC8

HOXC8
Identifiers
Aliases	HOXC8 , HOX3, HOX3A, homeobox C8
External IDs	OMIM: 142970 MGI: 96198 HomoloGene: 130642 GeneCards: HOXC8
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q13.13 Start 54,008,985 bp [1] End 54,012,769 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve gastrocnemius muscle left uterine tube subcutaneous adipose tissue popliteal artery skeletal muscle tissue skin of abdomen kidney right uterine tube saphenous vein n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component microtubule cytoskeleton nucleus nucleoplasm Biological process multicellular organism development skeletal system morphogenesis regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated anterior/posterior pattern specification neuron differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3224 15426 Ensembl ENSG00000037965 n/a UniProt P31273 P09025 RefSeq (mRNA) NM_022658 NM_010466 RefSeq (protein) NP_073149 NP_034596 Location (UCSC) Chr 12: 54.01 – 54.01 Mb n/a PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein Hox-C8 is a protein that in humans is encoded by the HOXC8 gene. ^{[4] [5] [6]}

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders. ^[6] HOXC8 was found to have activity in promoting nerve growth and its expression is dysregulated in patients with neurofibromatosis type 1. ^[7]

See also

• Homeobox

Interactions

HOXC8 has been shown to interact with Mothers against decapentaplegic homolog 6 ^[8] and Mothers against decapentaplegic homolog 1. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000037965 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID   1973146.
5. Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID   1358459. S2CID   13370372.
6. "Entrez Gene: HOXC8 homeobox C8".
7. Liu Y, Kang D, Li C, Xu G, Tan Y, Wang J (Jan 2014). "Microarray‑based identification of nerve growth‑promoting genes in neurofibromatosis type I". Mol Med Rep. 9 (1): 192–6. doi: 10.3892/mmr.2013.1785 . PMID   24213587.
8. Bai S, Shi X, Yang X, Cao X (March 2000). "Smad6 as a transcriptional corepressor". J. Biol. Chem. 275 (12): 8267–70. doi: 10.1074/jbc.275.12.8267 . PMID   10722652.
9. Shi X, Yang X, Chen D, Chang Z, Cao X (May 1999). "Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling". J. Biol. Chem. 274 (19): 13711–7. doi: 10.1074/jbc.274.19.13711 . PMID   10224145.

Further reading

• Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (1989). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC   335308 . PMID   2574852.
• Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A (1989). "Organization of human class I homeobox genes". Genome. 31 (2): 745–56. doi:10.1139/g89-133. PMID   2576652.
• Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH (1986). "Cognate homeo-box loci mapped on homologous human and mouse chromosomes". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 9104–8. Bibcode:1986PNAS...83.9104R. doi: 10.1073/pnas.83.23.9104 . PMC   387083 . PMID   2878432.
• Simeone A, Mavilio F, Acampora D, Giampaolo A, Faiella A, Zappavigna V, D'Esposito M, Pannese M, Russo G, Boncinelli E (1987). "Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development". Proc. Natl. Acad. Sci. U.S.A. 84 (14): 4914–8. Bibcode:1987PNAS...84.4914S. doi: 10.1073/pnas.84.14.4914 . PMC   305217 . PMID   2885844.
• Cannizzaro LA, Croce CM, Griffin CA, Simeone A, Boncinelli E, Huebner K (1987). "Human homeo box-containing genes located at chromosome regions 2q31----2q37 and 12q12----12q13". Am. J. Hum. Genet. 41 (1): 1–15. PMC   1684175 . PMID   2886047.
• Lawrence HJ, Stage KM, Mathews CH, Detmer K, Scibienski R, MacKenzie M, Migliaccio E, Boncinelli E, Largman C (1993). "Expression of HOX C homeobox genes in lymphoid cells". Cell Growth Differ. 4 (8): 665–9. PMID   8104467.
• Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–5. doi:10.1159/000134320. PMID   8646877.
• Flagiello D, Gibaud A, Dutrillaux B, Poupon MF, Malfoy B (1997). "Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines". FEBS Lett. 415 (3): 263–7. doi:10.1016/S0014-5793(97)01118-6. PMID   9357979. S2CID   26075369.
• Shi X, Yang X, Chen D, Chang Z, Cao X (1999). "Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling". J. Biol. Chem. 274 (19): 13711–7. doi: 10.1074/jbc.274.19.13711 . PMID   10224145.
• Prévôt D, Voeltzel T, Birot AM, Morel AP, Rostan MC, Magaud JP, Corbo L (2000). "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation". J. Biol. Chem. 275 (1): 147–53. doi: 10.1074/jbc.275.1.147 . PMID   10617598.
• Bai S, Shi X, Yang X, Cao X (2000). "Smad6 as a transcriptional corepressor". J. Biol. Chem. 275 (12): 8267–70. doi: 10.1074/jbc.275.12.8267 . PMID   10722652.
• Wan M, Shi X, Feng X, Cao X (2001). "Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegrin gene expression". J. Biol. Chem. 276 (13): 10119–25. doi: 10.1074/jbc.M006918200 . PMID   11139569.
• Schaefer LK, Wang S, Schaefer TS (2001). "Functional interaction of Jun and homeodomain proteins". J. Biol. Chem. 276 (46): 43074–82. doi: 10.1074/jbc.M102552200 . PMID   11551904.
• Waltregny D, Alami Y, Clausse N, de Leval J, Castronovo V (2002). "Overexpression of the homeobox gene HOXC8 in human prostate cancer correlates with loss of tumor differentiation". Prostate. 50 (3): 162–9. doi:10.1002/pros.10045. PMID   11813208. S2CID   32810610.
• Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID   11857506.
• Bayarsaihan D, Enkhmandakh B, Makeyev A, Greally JM, Leckman JF, Ruddle FH (2003). "Homez, a homeobox leucine zipper gene specific to the vertebrate lineage". Proc. Natl. Acad. Sci. U.S.A. 100 (18): 10358–63. Bibcode:2003PNAS..10010358B. doi: 10.1073/pnas.1834010100 . PMC   193566 . PMID   12925734.
• Luo L, Yang X, Takihara Y, Knoetgen H, Kessel M (2004). "The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions" (PDF). Nature. 427 (6976): 749–53. Bibcode:2004Natur.427..749L. doi:10.1038/nature02305. hdl: 11858/00-001M-0000-0012-EE33-0 . PMID   14973489. S2CID   8020382.

External links

• HOXC8+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.