HSF4

Last updated
HSF4
Identifiers
Aliases HSF4 , CTM, CTRCT5, heat shock transcription factor 4
External IDs OMIM: 602438 MGI: 1347058 HomoloGene: 100128 GeneCards: HSF4
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001538
NM_001040667
NM_001374674
NM_001374675

NM_001256042
NM_001256044
NM_011939

RefSeq (protein)

NP_001035757
NP_001529
NP_001361603
NP_001361604

NP_001242971
NP_001242973
NP_036069

Location (UCSC) Chr 16: 67.16 – 67.17 Mb Chr 8: 105.27 – 105.28 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Heat shock factor protein 4 is a protein that in humans is encoded by the HSF4 gene. [5] [6] [7] [8]

Contents

Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [8]

See also

Related Research Articles

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000102878 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033249 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nakai A, Tanabe M, Kawazoe Y, Inazawa J, Morimoto RI, Nagata K (Jan 1997). "HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator". Mol Cell Biol. 17 (1): 469–81. doi:10.1128/mcb.17.1.469. PMC   231772 . PMID   8972228.
  6. Tanabe M, Sasai N, Nagata K, Liu XD, Liu PC, Thiele DJ, Nakai A (Nov 1999). "The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing". J Biol Chem. 274 (39): 27845–56. doi: 10.1074/jbc.274.39.27845 . PMID   10488131.
  7. Bu L, Jin Y, Shi Y, Chu R, Ban A, Eiberg H, Andres L, Jiang H, Zheng G, Qian M, Cui B, Xia Y, Liu J, Hu L, Zhao G, Hayden MR, Kong X (Jun 2002). "Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract". Nat Genet. 31 (3): 276–8. doi:10.1038/ng921. PMID   12089525. S2CID   27368940.
  8. 1 2 "Entrez Gene: HSF4 heat shock transcription factor 4".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.