BACH2

BACH2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3OHU, 3OHV
Identifiers
Aliases	BACH2 , BTBD25, BTB domain and CNC homolog 2, IMD60
External IDs	OMIM: 605394; MGI: 894679; HomoloGene: 7240; GeneCards: BACH2; OMA:BACH2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q15 Start 89,926,528 bp [1] End 90,296,843 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 A5 Start 32,238,804 bp [2] End 32,586,108 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve epithelium of nasopharynx oocyte bone marrow secondary oocyte thymus ganglionic eminence tonsil lymph node ventricular zone Top expressed in zygote mesenteric lymph nodes trigeminal ganglion Rostral migratory stream blood tibiofemoral joint spleen hand hair follicle ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific ubiquitin-protein transferase activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm Cul3-RING ubiquitin ligase complex nucleus cytosol Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription, DNA-templated protein ubiquitination import into nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 60468 12014 Ensembl ENSG00000112182 ENSMUSG00000040270 UniProt Q9BYV9 P97303 RefSeq (mRNA) NM_001170794 NM_021813 NM_001109661 NM_007521 RefSeq (protein) NP_001164265 NP_068585 NP_001103131 Location (UCSC) Chr 6: 89.93 – 90.3 Mb Chr 4: 32.24 – 32.59 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transcription regulator protein BACH2 (broad complex-tramtrack-bric a brac and Cap'n'collar homology 2) is a protein that in humans is encoded by the BACH2 gene. ^{[5] [6] [7]} It contains a BTB/POZ domain at its N-terminus which forms a disulphide-linked dimer ^[8] and a bZip_Maf domain at the C-terminus.

References

1. GRCh38: Ensembl release 89: ENSG00000112182 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040270 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sasaki S, Ito E, Toki T, Maekawa T, Kanezaki R, Umenai T, Muto A, Nagai H, Kinoshita T, Yamamoto M, Inazawa J, Taketo MM, Nakahata T, Igarashi K, Yokoyama M (August 2000). "Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15". Oncogene. 19 (33): 3739–49. doi: 10.1038/sj.onc.1203716 . PMID   10949928.
6. Kamio T, Toki T, Kanezaki R, Sasaki S, Tandai S, Terui K, Ikebe D, Igarashi K, Ito E (November 2003). "B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs". Blood. 102 (9): 3317–22. doi: 10.1182/blood-2002-12-3656 . PMID   12829606.
7. "Entrez Gene: BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2".
8. Rosbrook GO, Stead MA, Carr SB, Wright SC (January 2012). "The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond" (PDF). Acta Crystallographica Section D. 68 (Pt 1): 26–34. Bibcode:2012AcCrD..68...26R. doi:10.1107/S0907444911048335. PMID   22194330.

Further reading

• Oyake T, Itoh K, Motohashi H, Hayashi N, Hoshino H, Nishizawa M, Yamamoto M, Igarashi K (November 1996). "Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site". Molecular and Cellular Biology. 16 (11): 6083–95. doi:10.1128/mcb.16.11.6083. PMC   231611 . PMID   8887638.
• Kobayashi A, Yamagiwa H, Hoshino H, Muto A, Sato K, Morita M, Hayashi N, Yamamoto M, Igarashi K (March 2000). "A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain". Molecular and Cellular Biology. 20 (5): 1733–46. doi:10.1128/MCB.20.5.1733-1746.2000. PMC   85356 . PMID   10669750.
• Hoshino H, Kobayashi A, Yoshida M, Kudo N, Oyake T, Motohashi H, Hayashi N, Yamamoto M, Igarashi K (May 2000). "Oxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element". The Journal of Biological Chemistry. 275 (20): 15370–6. doi: 10.1074/jbc.275.20.15370 . PMID   10809773.
• Vieira SA, Deininger MW, Sorour A, Sinclair P, Foroni L, Goldman JM, Melo JV (December 2001). "Transcription factor BACH2 is transcriptionally regulated by the BCR/ABL oncogene". Genes, Chromosomes & Cancer. 32 (4): 353–63. doi:10.1002/gcc.1200. PMID   11746976. S2CID   21020332.
• Muto A, Tashiro S, Tsuchiya H, Kume A, Kanno M, Ito E, Yamamoto M, Igarashi K (June 2002). "Activation of Maf/AP-1 repressor Bach2 by oxidative stress promotes apoptosis and its interaction with promyelocytic leukemia nuclear bodies". The Journal of Biological Chemistry. 277 (23): 20724–33. doi: 10.1074/jbc.M112003200 . PMID   11923289.
• Takakuwa T, Luo WJ, Ham MF, Sakane-Ishikawa F, Wada N, Aozasa K (March 2004). "Integration of Epstein-Barr virus into chromosome 6q15 of Burkitt lymphoma cell line (Raji) induces loss of BACH2 expression". The American Journal of Pathology. 164 (3): 967–74. doi:10.1016/S0002-9440(10)63184-7. PMC   1614712 . PMID   14982850.
• Tashiro S, Muto A, Tanimoto K, Tsuchiya H, Suzuki H, Hoshino H, Yoshida M, Walter J, Igarashi K (April 2004). "Repression of PML nuclear body-associated transcription by oxidative stress-activated Bach2". Molecular and Cellular Biology. 24 (8): 3473–84. doi:10.1128/MCB.24.8.3473-3484.2004. PMC   381671 . PMID   15060166.
• Motamed-Khorasani A, Jurisica I, Letarte M, Shaw PA, Parkes RK, Zhang X, Evangelou A, Rosen B, Murphy KJ, Brown TJ (January 2007). "Differentially androgen-modulated genes in ovarian epithelial cells from BRCA mutation carriers and control patients predict ovarian cancer survival and disease progression". Oncogene. 26 (2): 198–214. doi:10.1038/sj.onc.1209773. PMID   16832351. S2CID   23262017.
• Yoshida C, Yoshida F, Sears DE, Hart SM, Ikebe D, Muto A, Basu S, Igarashi K, Melo JV (February 2007). "Bcr-Abl signaling through the PI-3/S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2, which represses the antiapoptotic factor heme oxygenase-1". Blood. 109 (3): 1211–9. doi: 10.1182/blood-2005-12-040972 . PMID   17018862. S2CID   10475263.
• Ono A, Kono K, Ikebe D, Muto A, Sun J, Kobayashi M, Ueda K, Melo JV, Igarashi K, Tashiro S (January 2007). "Nuclear positioning of the BACH2 gene in BCR-ABL positive leukemic cells". Genes, Chromosomes & Cancer. 46 (1): 67–74. doi:10.1002/gcc.20390. PMID   17044046. S2CID   13276741.
• Ikeda T, Shibata J, Yoshimura K, Koito A, Matsushita S (March 2007). "Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy". The Journal of Infectious Diseases. 195 (5): 716–25. doi: 10.1086/510915 . PMID   17262715.
• Hoshino H, Nishino TG, Tashiro S, Miyazaki M, Ohmiya Y, Igarashi K, Horinouchi S, Yoshida M (May 2007). "Co-repressor SMRT and class II histone deacetylases promote Bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression". Journal of Biochemistry. 141 (5): 719–27. CiteSeerX   10.1.1.326.4123 . doi:10.1093/jb/mvm073. PMID   17383980.

External links

• BACH2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human BACH2 genome location and BACH2 gene details page in the UCSC Genome Browser .
• Overview of all the structural information available in the PDB for UniProt : Q9BYV9 (Transcription regulator protein BACH2) at the PDBe-KB .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.