HLF (gene)

Last updated

HLF
Identifiers
Aliases HLF , PAR bZIP transcription factor, HLF transcription factor, PAR bZIP family member
External IDs OMIM: 142385; MGI: 96108; HomoloGene: 31074; GeneCards: HLF; OMA:HLF - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002126
NM_001330375

NM_172563

RefSeq (protein)

NP_001317304
NP_002117

Location (UCSC) Chr 17: 55.26 – 55.33 Mb Chr 11: 90.23 – 90.28 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Hepatic leukemia factor is a protein that in humans is encoded by the HLF gene. [5] [6]

Function

This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [6]

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000108924 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003949 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Inaba T, Roberts WM, Shapiro LH, Jolly KW, Raimondi SC, Smith SD, Look AT (July 1992). "Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia". Science. 257 (5069): 531–4. Bibcode:1992Sci...257..531I. doi:10.1126/science.1386162. PMID   1386162.
  6. 1 2 "Entrez Gene: HLF hepatic leukemia factor".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.