TOX2

Last updated
TOX high mobility group box family member 2
Identifiers
SymbolTOX2
Alt. symbolsC20orf100, GCX-1
NCBI gene 84969
HGNC 16095
OMIM 611163
RefSeq NM_001098796
UniProt Q96NM4
Other data
Locus Chr. 20 q13.12

TOX high mobility group box family member 2, also known as TOX2, is a human gene. [1] [2]

The protein encoded by this gene is a member of a subfamily of transcription factors that also includes TOX, TOX3, and TOX4 that share almost identical HMG-box DNA-binding domains which function to modify chromatin structure. [3]

Related Research Articles

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High-Mobility Group or HMG is a group of chromosomal proteins that are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair.

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HMGB1 Mammalian protein found in Homo sapiens

High mobility group box 1 protein, also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a protein that in humans is encoded by the HMGB1 gene.

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High-mobility group protein HMG-I/HMG-Y is a protein that in humans is encoded by the HMGA1 gene.

Lymphoid enhancer-binding factor 1

Lymphoid enhancer-binding factor 1 (LEF1) is a protein that in humans is encoded by the LEF1 gene.

Structure specific recognition protein 1

FACT complex subunit SSRP1 also known as structure specific recognition protein 1 is a protein that in humans is encoded by the SSRP1 gene.

FOXL2 Transcription factor gene of the FOX family

Forkhead box protein L2 is a protein that in humans is encoded by the FOXL2 gene.

HMGB2 Protein-coding gene in the species Homo sapiens

High-mobility group protein B2 also known as high-mobility group protein 2 (HMG-2) is a protein that in humans is encoded by the HMGB2 gene.

SOX4 Protein-coding gene in the species Homo sapiens

Transcription factor SOX-4 is a protein that in humans is encoded by the SOX4 gene.

HBP1

HMG-box transcription factor 1, also known as HBP1, is a human protein.

HMGN2

Non-histone chromosomal protein HMG-17 is a protein that in humans is encoded by the HMGN2 gene.

TCF7 Protein-coding gene in the species Homo sapiens

Transcription factor 7 is the gene that in humans encodes for the TCF1 protein.

HMG20B

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related is a protein that in humans is encoded by the HMG20B gene.

SOX8

Transcription factor SOX-8 is a protein that in humans is encoded by the SOX8 gene.

SOX12

SOX12 is a protein that in humans is encoded by the SOX12 gene. Sox12 belongs to the SoxC group of Sox family of transcription factors, together with Sox4 and Sox11. Sox12-null knockout mice appear normal, unlike Sox4 or Sox11 knockout mice. This probably comes from functional redundancy with Sox4 and Sox11. Sox12 is a weaker activator than both Sox4 and Sox11 in mouse.

TOX

Thymocyte selection-associated high mobility group box protein TOX is a protein that in humans is encoded by the TOX gene. TOX drives T-cell exhaustion and plays a role in innate lymphoid cell development.

TOX4

TOX4 also known as KIAA0737, is a human gene.

TOX high mobility group box family member 3, also known as TOX3, is a human gene.

References

  1. "Entrez Gene: TOX high mobility group box family member 2".
  2. Kajitani T, Mizutani T, Yamada K, Yazawa T, Sekiguchi T, Yoshino M, Kawata H, Miyamoto K (May 2004). "Cloning and characterization of granulosa cell high-mobility group (HMG)-box protein-1, a novel HMG-box transcriptional regulator strongly expressed in rat ovarian granulosa cells". Endocrinology. 145 (5): 2307–18. doi: 10.1210/en.2003-1343 . PMID   14764631.
  3. O'Flaherty E, Kaye J (April 2003). "TOX defines a conserved subfamily of HMG-box proteins". BMC Genomics. 4 (1): 13. doi:10.1186/1471-2164-4-13. PMC   155677 . PMID   12697058.