FHL3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | FHL3 , SLIM2, four and a half LIM domains 3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 602790 MGI: 1341092 HomoloGene: 37928 GeneCards: FHL3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Four and a half LIM domains protein 3 is a protein that in humans is encoded by the FHL3 gene. [5] [6] [7]
LIM proteins are defined by the possession of a highly conserved double zinc finger motif called the LIM domain. [7]
FHL3 plays a role in myogenesis, [8] and also stimulates the development of neural crest by enhancing BMP signaling. [9]
FHL3 has been shown to interact with:
Mitogen-activated protein kinase 1, also known as ERK2, is an enzyme that in humans is encoded by the MAPK1 gene.
Four and a half LIM domains protein 1 is a protein that in humans is encoded by the FHL1 gene.
DNA replication licensing factor MCM7 is a protein that in humans is encoded by the MCM7 gene.
Four and a half LIM domains protein 2 also known as FHL-2 is a protein that in humans is encoded by the FHL2 gene. LIM proteins contain a highly conserved double zinc finger motif called the LIM domain.
LIM domain kinase 1 is an enzyme that in humans is encoded by the LIMK1 gene.
The alpha-1B adrenergic receptor (α1B-adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it. The crystal structure of the α1B-adrenergic receptor has been determined in complex with the inverse agonist (+)-cyclazosin.
Serum response factor, also known as SRF, is a transcription factor protein.
14-3-3 protein epsilon is a protein that in humans is encoded by the YWHAE gene.
C-terminal-binding protein 1 also known as CtBP1 is a protein that in humans is encoded by the CTBP1 gene. CtBP1 is one of two CtBP proteins, the other protein being CtBP2.
Zyxin is a protein that in humans is encoded by the ZYX gene.
Alpha-7 integrin is a protein that in humans is encoded by the ITGA7 gene. Alpha-7 integrin is critical for modulating cell-matrix interactions. Alpha-7 integrin is highly expressed in cardiac muscle, skeletal muscle and smooth muscle cells, and localizes to Z-disc and costamere structures. Mutations in ITGA7 have been associated with congenital myopathies and noncompaction cardiomyopathy, and altered expression levels of alpha-7 integrin have been identified in various forms of muscular dystrophy.
Heat shock protein beta-2 is a protein that in humans is encoded by the HSPB2 gene.
NEDD4-like E3 ubiquitin-protein ligase WWP1 is an enzyme that in humans is encoded by the WWP1 gene.
Triadin, also known as TRDN, is a human gene associated with the release of calcium ions from the sarcoplasmic reticulum triggering muscular contraction through calcium-induced calcium release. Triadin is a multiprotein family, arising from different processing of the TRDN gene on chromosome 6. It is a transmembrane protein on the sarcoplasmic reticulum due to a well defined hydrophobic section and it forms a quaternary complex with the cardiac ryanodine receptor (RYR2), calsequestrin (CASQ2) and junctin proteins. The luminal (inner compartment of the sarcoplasmic reticulum) section of Triadin has areas of highly charged amino acid residues that act as luminal Ca2+ receptors. Triadin is also able to sense luminal Ca2+ concentrations by mediating interactions between RYR2 and CASQ2. Triadin has several different forms; Trisk 95 and Trisk 51, which are expressed in skeletal muscle, and Trisk 32 (CT1), which is mainly expressed in cardiac muscle.
Eukaryotic translation initiation factor 3 subunit G (eIF3g) is a protein that in humans is encoded by the EIF3G gene.
PDZ and LIM domain protein 1 is a protein that in humans is encoded by the PDLIM1 gene.
Dual specificity tyrosine-phosphorylation-regulated kinase 1B is an enzyme that in humans is encoded by the DYRK1B gene.
Zinc finger protein 638 is a protein that in humans is encoded by the ZNF638 gene.
Cysteine-rich protein 2 is a protein that in humans is encoded by the CRIP2 gene.
Krüppel-like factor 3 is a protein that in humans is encoded by the KLF3 gene.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.