FHL3

Last updated

FHL3
Protein FHL3 PDB 1wyh.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FHL3 , SLIM2, four and a half LIM domains 3
External IDs OMIM: 602790 MGI: 1341092 HomoloGene: 37928 GeneCards: FHL3
Orthologs
SpeciesHumanMouse
Entrez

2275

14201

Ensembl

ENSG00000183386

ENSMUSG00000032643

UniProt

Q13643
Q96C98

Q9R059

RefSeq (mRNA)

NM_004468
NM_001243878

NM_010213

RefSeq (protein)

NP_001230807
NP_004459
NP_001230807.1

NP_034343

Location (UCSC) Chr 1: 38 – 38.01 Mb Chr 4: 124.59 – 124.6 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Four and a half LIM domains protein 3 is a protein that in humans is encoded by the FHL3 gene. [5] [6] [7]

Contents

LIM proteins are defined by the possession of a highly conserved double zinc finger motif called the LIM domain. [7]

Function

FHL3 plays a role in myogenesis, [8] and also stimulates the development of neural crest by enhancing BMP signaling. [9]

Interactions

FHL3 has been shown to interact with:

Related Research Articles

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000183386 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032643 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Morgan MJ, Madgwick AJ (October 1996). "Slim defines a novel family of LIM-proteins expressed in skeletal muscle". Biochem Biophys Res Commun. 225 (2): 632–8. doi:10.1006/bbrc.1996.1222. PMID   8753811.
  6. ↑ Lee SM, Tsui SK, Chan KK, Kotaka M, Li HY, Chim SS, Waye MM, Fung KP, Lee CY (May 1999). "Chromosomal mapping of a skeletal muscle specific LIM-only protein FHL3 to the distal end of the short arm of human chromosome 1". Somat Cell Mol Genet. 24 (3): 197–202. doi:10.1023/B:SCAM.0000007122.03392.4b. PMID   10226657. S2CID   40511123.
  7. 1 2 "Entrez Gene: FHL3 four and a half LIM domains 3".
  8. ↑ Cottle et al., J Cell Sci. 2007 Apr 15;120(Pt 8):1423-35. doi: 10.1242/jcs.004739
  9. ↑ Intracellular enhancement of BMP signaling by LIM-domain protein FHL3 controls spatiotemporal emergence of the neural crest driven by WNT signaling Mansour Alkobtawi, Patrick Pla, Anne H. Monsoro-Burq bioRxiv 711192; doi: https://doi.org/10.1101/711192
  10. 1 2 Fimia GM, De Cesare D, Sassone-Corsi P (November 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Mol. Cell. Biol. 20 (22): 8613–22. doi:10.1128/mcb.20.22.8613-8622.2000. PMC   102166 . PMID   11046156.
  11. 1 2 Turner J, Nicholas H, Bishop D, Matthews JM, Crossley M (April 2003). "The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2". J. Biol. Chem. 278 (15): 12786–95. doi: 10.1074/jbc.M300587200 . PMID   12556451.
  12. ↑ Li HY, Ng EK, Lee SM, Kotaka M, Tsui SK, Lee CY, Fung KP, Waye MM (2001). "Protein–protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two-fusion fluorescence resonance energy transfer (FRET)". J. Cell. Biochem. 80 (3): 293–303. doi:10.1002/1097-4644(20010301)80:3<293::AID-JCB10>3.0.CO;2-U. PMID   11135358. S2CID   36346381.
  13. ↑ Samson T, Smyth N, Janetzky S, Wendler O, Müller JM, Schüle R, von der Mark H, von der Mark K, Wixler V (July 2004). "The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor". J. Biol. Chem. 279 (27): 28641–52. doi: 10.1074/jbc.M312894200 . PMID   15117962.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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