HOXD1

Last updated
HOXD1
Identifiers
Aliases HOXD1 , HOX4, HOX4G, Hox-4.7, homeobox D1
External IDs OMIM: 142987; MGI: 96201; HomoloGene: 7772; GeneCards: HOXD1; OMA:HOXD1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024501

NM_010467

RefSeq (protein)

NP_078777

NP_034597

Location (UCSC) Chr 2: 176.19 – 176.19 Mb Chr 2: 74.59 – 74.6 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein Hox-D1 is a protein that in humans is encoded by the HOXD1 gene. [5] [6] [7]

Contents

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. This nuclear protein functions as a sequence-specific transcription factor that is involved in differentiation and limb development. Mutations in this gene have been associated with severe developmental defects on the anterior-posterior (a-p) limb axis. [7]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000128645 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042448 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID   1973146.
  6. Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID   1358459. S2CID   13370372.
  7. 1 2 "Entrez Gene: HOXD1 homeobox D1".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.