Testicular receptor

nuclear receptor subfamily 2, group C, member 2
nuclear receptor subfamily 2, group C, member 2
Identifiers
Symbol	NR2C2
Alt. symbols	TR4
NCBI gene	7182
HGNC	7972
OMIM	601426
RefSeq	NM_003298
UniProt	P49116
Other data
Locus	Chr. 3 p25
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Search for
Structures	Swiss-model
Domains	InterPro

nuclear receptor subfamily 2, group C, member 1
nuclear receptor subfamily 2, group C, member 1
Identifiers
Symbol	NR2C1
Alt. symbols	TR2
NCBI gene	7181
HGNC	7971
OMIM	601529
RefSeq	NM_003297
UniProt	P13056
Other data
Locus	Chr. 12 q22
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Last updated November 14, 2025

The testicular receptor proteins are members of the nuclear receptor family of intracellular transcription factors.^[1] There are two forms of the receptor, TR2 and TR4 , each encode by a separate gene ( NR2C1 and NR2C2 respectively).^[2]^[3]^[4]

References

↑ Lee YF, Lee HJ, Chang C (2002). "Recent advances in the TR2 and TR4 orphan receptors of the nuclear receptor superfamily". J. Steroid Biochem. Mol. Biol. 81 (4–5): 291–308. doi:10.1016/S0960-0760(02)00118-8. PMID 12361719. S2CID 11638283.
↑ Chang C, Kokontis J, Acakpo-Satchivi L, Liao S, Takeda H, Chang Y (1989). "Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains". Biochem. Biophys. Res. Commun. 165 (2): 735–41. Bibcode:1989BBRC..165..735C. doi:10.1016/S0006-291X(89)80028-2. PMID 2597158.
↑ Yoshikawa T, DuPont BR, Leach RJ, Detera-Wadleigh SD (1996). "New variants of the human and rat nuclear hormone receptor, TR4: expression and chromosomal localization of the human gene". Genomics. 35 (2): 361–6. doi:10.1006/geno.1996.0368. PMID 8661150.
↑ Chang C, Da Silva SL, Ideta R, Lee Y, Yeh S, Burbach JP (1994). "Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily". Proc. Natl. Acad. Sci. U.S.A. 91 (13): 6040–4. Bibcode:1994PNAS...91.6040C. doi: 10.1073/pnas.91.13.6040 . PMC 44133 . PMID 8016112.

External links

nuclear+receptor+subfamily+2,+group+C,+member+1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
NR2C2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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[pmid12361719-1] Lee YF, Lee HJ, Chang C (2002). "Recent advances in the TR2 and TR4 orphan receptors of the nuclear receptor superfamily". J. Steroid Biochem. Mol. Biol. 81 (4–5): 291–308. doi:10.1016/S0960-0760(02)00118-8. PMID 12361719. S2CID 11638283.

[pmid2597158-2] Chang C, Kokontis J, Acakpo-Satchivi L, Liao S, Takeda H, Chang Y (1989). "Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains". Biochem. Biophys. Res. Commun. 165 (2): 735–41. Bibcode:1989BBRC..165..735C. doi:10.1016/S0006-291X(89)80028-2. PMID 2597158.

[pmid8661150-3] Yoshikawa T, DuPont BR, Leach RJ, Detera-Wadleigh SD (1996). "New variants of the human and rat nuclear hormone receptor, TR4: expression and chromosomal localization of the human gene". Genomics. 35 (2): 361–6. doi:10.1006/geno.1996.0368. PMID 8661150.

[pmid8016112-4] Chang C, Da Silva SL, Ideta R, Lee Y, Yeh S, Burbach JP (1994). "Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily". Proc. Natl. Acad. Sci. U.S.A. 91 (13): 6040–4. Bibcode:1994PNAS...91.6040C. doi: 10.1073/pnas.91.13.6040 . PMC 44133 . PMID 8016112.

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