HMGN3

HMGN3
Identifiers
Aliases	HMGN3 , PNAS-25, TRIP7, PNAS-24, high mobility group nucleosomal binding domain 3
External IDs	OMIM: 604502 HomoloGene: 130417 GeneCards: HMGN3
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q14.1 Start 79,201,245 bp [1] End 79,234,738 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell endothelial cell palpebral conjunctiva right uterine tube parietal pleura visceral pleura hair follicle germinal epithelium glomerulus metanephric glomerulus n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleosomal DNA binding DNA binding chromatin binding thyroid hormone receptor binding Cellular component chromatin nucleus nucleoplasm cytosol Biological process regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of transcription by RNA polymerase II biological process chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9324 n/a Ensembl ENSG00000118418 n/a UniProt Q15651 n/a RefSeq (mRNA) NM_001201362 NM_001201363 NM_004242 NM_138730 NM_001318884 NM_001318885 NM_001318886 NM_001318887 NM_001318888 n/a RefSeq (protein) NP_001188291 NP_001188292 NP_001305813 NP_001305814 NP_001305815 NP_001305816 NP_001305817 NP_004233 NP_620058 n/a Location (UCSC) Chr 6: 79.2 – 79.23 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

High mobility group nucleosome-binding domain-containing protein 3 is a protein that in humans is encoded by the HMGN3 gene. ^{[3] [4] [5]}

Thyroid hormone receptors are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. The protein encoded by this gene binds thyroid hormone receptor beta, but only in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Two transcript variants encoding different isoforms have been found for this gene. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000118418 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (Jul 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol. 9 (2): 243–54. doi: 10.1210/mend.9.2.7776974 . PMID   7776974.
4. West KL, Ito Y, Birger Y, Postnikov Y, Shirakawa H, Bustin M (Jul 2001). "HMGN3a and HMGN3b, two protein isoforms with a tissue-specific expression pattern, expand the cellular repertoire of nucleosome-binding proteins". J Biol Chem. 276 (28): 25959–69. doi: 10.1074/jbc.M101692200 . PMID   11356838.
5. "Entrez Gene: HMGN3 high mobility group nucleosomal binding domain 3".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi: 10.1038/nature02055 . PMID   14574404.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Leong PW, Liew K, Lim W, Chow VT (2002). "Differential display RT-PCR analysis of enterovirus-71-infected rhabdomyosarcoma cells reveals mRNA expression responses of multiple human genes with known and novel functions". Virology. 295 (1): 147–59. doi: 10.1006/viro.2002.1353 . PMID   12033773.

External links

• FactorBook HMGN3