PKNOX1

Last updated
PKNOX1
Protein PKNOX1 PDB 1x2n.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PKNOX1 , PREP1, pkonx1c, PBX/knotted 1 homeobox 1
External IDs OMIM: 602100 MGI: 1201409 HomoloGene: 3363 GeneCards: PKNOX1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001286258
NM_004571
NM_001320694
NM_197976

NM_016670

RefSeq (protein)

NP_057879

Location (UCSC) Chr 21: 42.97 – 43.03 Mb Chr 17: 31.78 – 31.83 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

PBX/Knotted 1 Homeobox 1 (PKNOX1) is a protein that in humans is encoded by the PKNOX1 gene. [5] [6]

Contents

An important paralog of this gene is PKNOX2 .

Function

PKNOX1 belongs to the three amino acid loop extension (TALE) class of homeodomain transcription factors that form transcriptionally active complexes involved in development and organogenesis. PKNOX1 is essential for embryogenesis, but it can also act as a tumor suppressor in adulthood. [7]

Related Research Articles

<span class="mw-page-title-main">PBX1</span> Protein found in humans

Pre-B-cell leukemia transcription factor 1 is a protein that in humans is encoded by the PBX1 gene. The homologous protein in Drosophila is known as extradenticle, and causes changes in embryonic development.

<span class="mw-page-title-main">Homeobox protein MSX-1</span> Protein-coding gene in the species Homo sapiens

Homeobox protein MSX-1, is a protein that in humans is encoded by the MSX1 gene. MSX1 transcripts are not only found in thyrotrope-derived TSH cells, but also in the TtT97 thyrotropic tumor, which is a well differentiated hyperplastic tissue that produces both TSHß- and a-subunits and is responsive to thyroid hormone. MSX1 is also expressed in highly differentiated pituitary cells which until recently was thought to be expressed exclusively during embryogenesis. There is a highly conserved structural organization of the members of the MSX family of genes and their abundant expression at sites of inductive cell–cell interactions in the embryo suggest that they have a pivotal role during early development.

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<span class="mw-page-title-main">Homeobox A1</span> Protein-coding gene in humans

Homeobox protein Hox-A1 is a protein that in humans is encoded by the HOXA1 gene.

<span class="mw-page-title-main">MEIS1</span> Protein-coding gene in humans

Homeobox protein Meis1 is a protein that in humans is encoded by the MEIS1 gene.

<span class="mw-page-title-main">HOXD10</span> Protein-coding gene in humans

Homeobox D10, also known as HOXD10, is a protein which in humans is encoded by the HOXD10 gene.

<span class="mw-page-title-main">HOXB5</span> Protein-coding gene in humans

Homeobox protein Hox-B5 is a protein that in humans is encoded by the HOXB5 gene.

<span class="mw-page-title-main">HOXA7</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-A7 is a protein that in humans is encoded by the HOXA7 gene.

<span class="mw-page-title-main">HOXB1</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-B1 is a protein that in humans is encoded by the HOXB1 gene.

<span class="mw-page-title-main">HOXB2</span> Protein-coding gene in humans

Homeobox protein Hox-B2 is a protein that in humans is encoded by the HOXB2 gene.

<span class="mw-page-title-main">HOXB9</span> Protein-coding gene in humans

Homeobox protein Hox-B9 is a protein that in humans is encoded by the HOXB9 gene.

<span class="mw-page-title-main">HOXB3</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-B3 is a protein that in humans is encoded by the HOXB3 gene.

<span class="mw-page-title-main">HOXC4</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">HOXD9</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-D9 is a protein that in humans is encoded by the HOXD9 gene.

<span class="mw-page-title-main">PBX2</span> Protein found in humans

Pre-B-cell leukemia transcription factor 2 is a protein that in humans is encoded by the PBX2 gene.

<span class="mw-page-title-main">HOXD4</span> Protein-coding gene

Homeobox protein Hox-D4 is a protein that in humans is encoded by the HOXD4 gene.

<span class="mw-page-title-main">HOXD12</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-D12 is a protein that in humans is encoded by the HOXD12 gene.

<span class="mw-page-title-main">HOXC5</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C5 is a protein that in humans is encoded by the HOXC5 gene.

<span class="mw-page-title-main">PKNOX2</span> Protein-coding gene in the species Homo sapiens

PBX/Knotted 1 Homeobox 2 (PKNOX2) protein belongs to the three amino acid loop extension (TALE) class of homeodomain proteins, and is encoded by PKNOX2 gene in humans. The protein regulates the transcription of other genes and affects anatomical development.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000160199 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006705 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Berthelsen J, Viggiano L, Schulz H, Ferretti E, Consalez GG, Rocchi M, Blasi F (January 1998). "PKNOX1, a gene encoding PREP1, a new regulator of Pbx activity, maps on human chromosome 21q22.3 and murine chromosome 17B/C". Genomics. 47 (2): 323–4. doi:10.1006/geno.1997.5086. PMID   9479508.
  6. "Entrez Gene: PKNOX1 PBX/knotted 1 homeobox 1".
  7. Purushothaman D, Blasi F (2018). "The genetics and the molecular functions of the PREP1 homeodomain transcription factor". The International Journal of Developmental Biology. 62 (11–12): 819–825. doi: 10.1387/ijdb.180238fb . PMID   30604851.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.