NFE2

Last updated
NFE2
Protein NFE2 PDB 1LVX.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NFE2 , NF-E2, p45, nuclear factor, erythroid 2
External IDs OMIM: 601490 MGI: 97308 HomoloGene: 4491 GeneCards: NFE2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)

NP_001129495
NP_001248390
NP_006154

Location (UCSC) Chr 12: 54.29 – 54.3 Mb Chr 15: 103.16 – 103.17 Mb
PubMed search [3] [4]
Wikidata
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Transcription factor NF-E2 45 kDa subunit is a protein that in humans is encoded by the NFE2 gene. [5] [6]

Contents

It is involved in megakaryocyte production. [7]

Interactions

NFE2 has been shown to interact with CREB-binding protein. [8]

Related Research Articles

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CCAAT/enhancer-binding protein beta is a protein that in humans is encoded by the CEBPB gene.

NRF1 Protein-coding gene in the species Homo sapiens

Nuclear respiratory factor 1, also known as Nrf1, Nrf-1, NRF1 and NRF-1, encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor -like 1" which has an official symbol of NFE2L1.

NFYB Protein-coding gene in the species Homo sapiens

Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene.

ATF6

Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene and is involved in the unfolded protein response.

CTBP1

C-terminal-binding protein 1 also known as CtBP1 is a protein that in humans is encoded by the CTBP1 gene. CtBP1 is one of two CtBP proteins, the other protein being CtBP2.

SPI1

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ID3 (gene) Protein-coding gene in the species Homo sapiens

DNA-binding protein inhibitor ID-3 is a protein that in humans is encoded by the ID3 gene.

KLF2 Protein-coding gene in the species Homo sapiens

Krüppel-like Factor 2 (KLF2), also known as lung Krüppel-like Factor (LKLF), is a protein that in humans is encoded by the KLF2 gene on chromosome 19. It is in the Krüppel-like factor family of zinc finger transcription factors, and it has been implicated in a variety of biochemical processes in the human body, including lung development, embryonic erythropoiesis, epithelial integrity, T-cell viability, and adipogenesis.

BACH1 Protein-coding gene in the species Homo sapiens

Transcription regulator protein BACH1 is a protein that in humans is encoded by the BACH1 gene.

IRF8 Protein-coding gene in the species Homo sapiens

Interferon regulatory factor 8 (IRF8) also known as interferon consensus sequence-binding protein (ICSBP), is a protein that in humans is encoded by the IRF8 gene. IRF8 is a transcription factor that plays critical roles in the regulation of lineage commitment and in myeloid cell maturation including the decision for a common myeloid progenitor (CMP) to differentiate into a monocyte precursor cell.

NFYC

Nuclear transcription factor Y subunit gamma is a protein that in humans is encoded by the NFYC gene.

MAFG

Transcription factor MafG is a bZip Maf transcription factor protein that in humans is encoded by the MAFG gene.

NFE2L1 Protein-coding gene in the species Homo sapiens

Nuclear factor erythroid 2-related factor 1 (Nrf1) also known as nuclear factor erythroid-2-like 1 (NFE2L1) is a protein that in humans is encoded by the NFE2L1 gene. Since NFE2L1 is referred to as Nrf1, it is often confused with nuclear respiratory factor 1 (Nrf1).

ERAF

Alpha-hemoglobin-stabilizing protein is a protein that in humans is encoded by the ERAF gene.

MAFK

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MAFF (gene)

Transcription factor MafF is a bZip Maf transcription factor protein that in humans is encoded by the MAFF gene.

MAFA (gene)

Transcription factor MafA is a protein that in humans is encoded by the MAFA gene. It is a member of the Maf family of transcription factors.

KLF3

Krüppel-like factor 3 is a protein that in humans is encoded by the KLF3 gene.

NFE2L3

Nuclear factor -like factor 3, also known as NFE2L3 or 'NRF3', is a transcription factor that in humans is encoded by the Nfe2l3 gene.

Small Maf proteins are basic region leucine zipper-type transcription factors that can bind to DNA and regulate gene regulation. There are three small Maf (sMaf) proteins, namely MafF, MafG, and MafK, in vertebrates. HUGO Gene Nomenclature Committee (HGNC)-approved gene names of MAFF, MAFG and MAFK are “v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F, G, and K”, respectively.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000123405 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000058794 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ney PA, Andrews NC, Jane SM, Safer B, Purucker ME, Weremowicz S, Morton CC, Goff SC, Orkin SH, Nienhuis AW (Sep 1993). "Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner". Mol Cell Biol. 13 (9): 5604–12. doi:10.1128/mcb.13.9.5604. PMC   360284 . PMID   8355703.
  6. "Entrez Gene: NFE2 nuclear factor (erythroid-derived 2), 45kDa".
  7. Gasiorek JJ, Blank V (2015). "Regulation and function of the NFE2 transcription factor in hematopoietic and non-hematopoietic cells". Cellular and Molecular Life Sciences. 72 (12): 2323–2335. doi:10.1007/s00018-015-1866-6. PMID   25721735. S2CID   18020988.
  8. Hung HL, Kim AY, Hong W, Rakowski C, Blobel GA (Apr 2001). "Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation". J. Biol. Chem. 276 (14): 10715–21. doi: 10.1074/jbc.M007846200 . PMID   11154691.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.