FOXP4

Last updated
FOXP4
Identifiers
Aliases FOXP4 , hFKHLA, forkhead box P4
External IDs OMIM: 608924; MGI: 1921373; HomoloGene: 12536; GeneCards: FOXP4; OMA:FOXP4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001110824
NM_001110825
NM_028767

RefSeq (protein)

NP_001012426
NP_001012427
NP_612466

NP_001104294
NP_001104295
NP_083043
NP_001390898
NP_001390899

Location (UCSC) Chr 6: 41.55 – 41.6 Mb Chr 17: 48.18 – 48.24 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Forkhead box protein P4 is a protein that in humans is encoded by the FOXP4 gene. [5]

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. [5] It also is a major factor in developing Long COVID as such, increasing the chances of developing the little-understood syndrome 1.6 fold, a finding which has major implications for COVID-19 pandemic research. [6]

Related Research Articles

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Forkhead box protein P2 (FOXP2) is a protein that, in humans, is encoded by the FOXP2 gene. FOXP2 is a member of the forkhead box family of transcription factors, proteins that regulate gene expression by binding to DNA. It is expressed in the brain, heart, lungs and digestive system.

FOXproteins are a family of transcription factors that play important roles in regulating the expression of genes involved in cell growth, proliferation, differentiation, and longevity. Many FOX proteins are important to embryonic development. FOX proteins also have pioneering transcription activity by being able to bind condensed chromatin during cell differentiation processes.

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<span class="mw-page-title-main">FOXP1</span> Protein-coding gene in the species Homo sapiens

Forkhead box protein P1 is a protein that in humans is encoded by the FOXP1 gene. FOXP1 is necessary for the proper development of the brain, heart, and lung in mammals. It is a member of the large FOX family of transcription factors.

<span class="mw-page-title-main">FOXO3</span> Protein-coding gene in humans

Forkhead box O3, also known as FOXO3 or FOXO3a, is a human protein encoded by the FOXO3 gene.

<span class="mw-page-title-main">FOXM1</span> Protein-coding gene in humans

Forkhead box protein M1 is a protein that in humans is encoded by the FOXM1 gene. The protein encoded by this gene is a member of the FOX family of transcription factors. Its potential as a target for future cancer treatments led to it being designated the 2010 Molecule of the Year.

<span class="mw-page-title-main">FOXG1</span> Protein-coding gene in the species Homo sapiens

Forkhead box protein G1 is a protein that in humans is encoded by the FOXG1 gene.

<span class="mw-page-title-main">FOXE1</span> Mammalian protein found in Homo sapiens

Forkhead box protein E1 is a protein that in humans is encoded by the FOXE1 gene.

<span class="mw-page-title-main">FOXN3</span> Protein-coding gene in the species Homo sapiens

Forkhead box protein N3 is a protein that in humans is encoded by the FOXN3 gene.

<span class="mw-page-title-main">OLIG1</span> Protein-coding gene in the species Homo sapiens

Oligodendrocyte transcription factor 1 is a protein that in humans is encoded by the OLIG1 gene.

<span class="mw-page-title-main">HEYL</span> Protein-coding gene in the species Homo sapiens

Hairy/enhancer-of-split related with YRPW motif-like protein is a protein that in humans is encoded by the HEYL gene.

<span class="mw-page-title-main">JARID2</span> Protein-coding gene in the species Homo sapiens

Protein Jumonji is a protein that in humans is encoded by the JARID2 gene. JARID2 is a member of the alpha-ketoglutarate-dependent hydroxylase superfamily.

<span class="mw-page-title-main">MSC (gene)</span> Protein-coding gene in the species Homo sapiens

Musculin is a protein that in humans is encoded by the MSC gene.

<span class="mw-page-title-main">FOXD4</span> Protein-coding gene in the species Homo sapiens

Forkhead box protein D4 is a protein that in humans is encoded by the FOXD4 gene.

<span class="mw-page-title-main">FOXK1</span> Protein-coding gene in the species Homo sapiens

Forkhead box protein K1 is a transcription factor of the forkhead box family that in humans is encoded by the FOXK1 gene.

<span class="mw-page-title-main">OSR2 (gene)</span> Protein-coding gene in the species Homo sapiens

Protein odd-skipped-related 2 is a protein that in humans is encoded by the OSR2 gene. In mice, it is involved in the development of the palate and in suppressing the formation of teeth after the eruption of adult teeth.

<span class="mw-page-title-main">FOXA1</span> Protein-coding gene in the species Homo sapiens

Forkhead box protein A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha (HNF-3A), is a protein that in humans is encoded by the FOXA1 gene.

<span class="mw-page-title-main">FOXA2</span> Mammalian protein found in Homo sapiens

Forkhead box protein A2 (FOXA2), also known as hepatocyte nuclear factor 3-beta (HNF-3B), is a transcription factor that plays an important role during development, in mature tissues and, when dysregulated or mutated, also in cancer.

<span class="mw-page-title-main">FOXA3</span> Protein-coding gene in the species Homo sapiens

Hepatocyte nuclear factor 3-gamma (HNF-3G), also known as forkhead box protein A3 (FOXA3) or transcription factor 3G (TCF-3G) is a protein that in humans is encoded by the FOXA3 gene.

<span class="mw-page-title-main">FOXI1</span> Protein-coding gene in the species Homo sapiens

Forkhead box I1 is a protein that in humans is encoded by the FOXI1 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000137166 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023991 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: FOXP4 forkhead box P4".
  6. Ledford H (July 11, 2023). "Gene linked to long COVID found in analysis of thousands of patients". Nature. 619 (7970): 445. Bibcode:2023Natur.619..445L. doi:10.1038/d41586-023-02269-2. PMID   37433943. S2CID   259831412 via www.nature.com.

Further reading