ZBTB20

ZBTB20
Identifiers
Aliases	ZBTB20 , DPZF, HOF, ODA-8S, ZNF288, PRIMS, zinc finger and BTB domain containing 20
External IDs	OMIM: 606025; MGI: 1929213; HomoloGene: 9226; GeneCards: ZBTB20; OMA:ZBTB20 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q13.31 Start 114,314,500 bp [1] End 115,147,288 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16 B4|16 28.44 cM Start 42,875,881 bp [2] End 43,642,602 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis caput epididymis tail of epididymis renal medulla corpus callosum Achilles tendon Skeletal muscle tissue of biceps brachii external globus pallidus trigeminal ganglion glutes Top expressed in Rostral migratory stream vestibular membrane of cochlear duct utricle median eminence arcuate nucleus ciliary body aortic valve ascending aorta tunica media of zone of aorta retinal pigment epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleic acid binding DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific metal ion binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm nuclear body cytoplasm Biological process positive regulation of tumor necrosis factor production negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II negative regulation of gene expression transcription, DNA-templated positive regulation of interleukin-6 production positive regulation of interferon-beta production positive regulation of glycolytic process positive regulation of lipid biosynthetic process lipid homeostasis cellular response to glucose stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26137 56490 Ensembl ENSG00000181722 ENSMUSG00000022708 UniProt Q9HC78 Q8K0L9 RefSeq (mRNA) NM_001164342 NM_001164343 NM_001164344 NM_001164345 NM_001164346 NM_001164347 NM_015642 NM_001348800 NM_001348802 NM_001348803 NM_001348804 NM_001348805 NM_001348801 NM_001393393 NM_001393394 NM_001393395 NM_001393396 NM_001285805 NM_019778 NM_181058 RefSeq (protein) NP_001157814 NP_001157815 NP_001157816 NP_001157817 NP_001157818 NP_001157819 NP_056457 NP_001335729 NP_001335731 NP_001335732 NP_001335733 NP_001335734 NP_001335730 NP_001272734 NP_062752 NP_851401 NP_001380326 NP_001380327 NP_001380328 Location (UCSC) Chr 3: 114.31 – 115.15 Mb Chr 16: 42.88 – 43.64 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger and BTB domain-containing protein 20 is a protein that in humans is encoded by the ZBTB20 gene. ^{[5] [6] [7]}

A mutation in a ZBTB20 gene causes Primrose syndrome. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000181722 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022708 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Harboe TL, Tümer Z, Hansen C, Jensen NA, Tommerup N (Sep 2000). "Assignment of the human zinc finger gene, ZNF288, to chromosome 3 band q13.2 by radiation hybrid mapping and fluorescence in situ hybridisation". Cytogenetics and Cell Genetics. 89 (3–4): 156–157. doi:10.1159/000015600. PMID   10965110. S2CID   36861164.
6. Zhang W, Mi J, Li N, Sui L, Wan T, Zhang J, et al. (April 2001). "Identification and characterization of DPZF, a novel human BTB/POZ zinc finger protein sharing homology to BCL-6". Biochemical and Biophysical Research Communications. 282 (4): 1067–1073. doi:10.1006/bbrc.2001.4689. PMID   11352661.
7. "Entrez Gene: ZBTB20 zinc finger and BTB domain containing 20".
8. "Entry- #259050 - PRIMROSE SYNDROME; PRIMS- OMIM- (OMIM.ORG)". www.omim.org. Retrieved 2025-07-02.

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, et al. (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, et al. (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415 –D418. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Cordeddu V, Redeker B, Stellacci E, Jongejan A, Fragale A, Bradley TE, et al. (August 2014). "Mutations in ZBTB20 cause Primrose syndrome". Nature Genetics. 46 (8): 815–817. doi:10.1038/ng.3035. PMID   25017102. S2CID   23567698.

External links

• ZBTB20+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.