LYL1

Last updated
LYL1
Identifiers
Aliases LYL1 , bHLHa18, lymphoblastic leukemia associated hematopoiesis regulator 1, basic helix-loop-helix family member, LYL1 basic helix-loop-helix family member
External IDs OMIM: 151440 MGI: 96891 HomoloGene: 4078 GeneCards: LYL1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005583

NM_008535

RefSeq (protein)

NP_005574

NP_032561

Location (UCSC) Chr 19: 13.1 – 13.1 Mb Chr 8: 85.43 – 85.43 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein lyl-1 is a protein that in humans is encoded by the LYL1 gene. [5] [6]

Contents

Interactions

LYL1 has been shown to interact with TCF3 [7] and NFKB1. [8]

Related Research Articles

Inhibitor of DNA-binding/differentiation proteins, also known as ID proteins comprise a family of proteins that heterodimerize with basic helix-loop-helix (bHLH) transcription factors to inhibit DNA binding of bHLH proteins. ID proteins also contain the HLH-dimerization domain but lack the basic DNA-binding domain and thus regulate bHLH transcription factors when they heterodimerize with bHLH proteins. The first helix-loop-helix proteins identified were named E-proteins because they bind to Ephrussi-box (E-box) sequences. In normal development, E proteins form dimers with other bHLH transcription factors, allowing transcription to occur. However, in cancerous phenotypes, ID proteins can regulate transcription by binding E proteins, so no dimers can be formed and transcription is inactive. E proteins are members of the class I bHLH family and form dimers with bHLH proteins from class II to regulate transcription. Four ID proteins exist in humans: ID1, ID2, ID3, and ID4. The ID homologue gene in Drosophila is called extramacrochaetae (EMC) and encodes a transcription factor of the helix-loop-helix family that lacks a DNA binding domain. EMC regulates cell proliferation, formation of organs like the midgut, and wing development. ID proteins could be potential targets for systemic cancer therapies without inhibiting the functioning of most normal cells because they are highly expressed in embryonic stem cells, but not in differentiated adult cells. Evidence suggests that ID proteins are overexpressed in many types of cancer. For example, ID1 is overexpressed in pancreatic, breast, and prostate cancers. ID2 is upregulated in neuroblastoma, Ewing’s sarcoma, and squamous cell carcinoma of the head and neck.

Aryl hydrocarbon receptor nuclear translocator Protein-coding gene in the species Homo sapiens

The ARNT gene encodes the aryl hydrocarbon receptor nuclear translocator protein that forms a complex with ligand-bound aryl hydrocarbon receptor (AhR), and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Three alternatively spliced variants encoding different isoforms have been described for this gene.

BCR (gene)

The breakpoint cluster region protein (BCR) also known as renal carcinoma antigen NY-REN-26 is a protein that in humans is encoded by the BCR gene. BCR is one of the two genes in the BCR-ABL fusion protein, which is associated with the Philadelphia chromosome. Two transcript variants encoding different isoforms have been found for this gene.

TAL1 Protein-coding gene in the species Homo sapiens

T-cell acute lymphocytic leukemia protein 1 is a protein that in humans is encoded by the TAL1 gene.

MYC Protein-coding gene in the species Homo sapiens

MYC proto-oncogene, bHLH transcription factor is a protein that in humans is encoded by the MYC gene which is a member of the myc family of transcription factors. The protein contains basic helix-loop-helix (bHLH) structural motif.

TCF3 Protein-coding gene in the species Homo sapiens

Transcription factor 3, also known as TCF3, is a protein that in humans is encoded by the TCF3 gene. TCF3 has been shown to directly enhance Hes1 expression.

ID2 Protein-coding gene in the species Homo sapiens

DNA-binding protein inhibitor ID-2 is a protein that in humans is encoded by the ID2 gene.

PBX1 Protein found in humans

Pre-B-cell leukemia transcription factor 1 is a protein that in humans is encoded by the PBX1 gene.

LMO2

LIM domain only 2, also known as LMO2, RBTNL1, RBTN2, RHOM2, LIM Domain Only Protein 2, TTG2, and T-Cell Translocation Protein 2, is a protein which in humans is encoded by the LMO2 gene.

ID1 Protein-coding gene in the species Homo sapiens

DNA-binding protein inhibitor ID-1 is a protein that in humans is encoded by the ID1 gene.

MAX (gene) Protein-coding gene in the species Homo sapiens

MAX is a gene that in humans encodes the MAX transcription factor.

ID3 (gene) Protein-coding gene in the species Homo sapiens

DNA-binding protein inhibitor ID-3 is a protein that in humans is encoded by the ID3 gene.

PKNOX1 Protein-coding gene in the species Homo sapiens

PBX/Knotted 1 Homeobox 1 (PKNOX1) is a protein that in humans is encoded by the PKNOX1 gene.

<i>HLF</i> (gene) Protein-coding gene in the species Homo sapiens

Hepatic leukemia factor is a protein that in humans is encoded by the HLF gene.

LMO1

Rhombotin-1 is a protein that in humans is encoded by the LMO1 gene.

ID4 Protein-coding gene in humans

ID4 is a protein coding gene. In humans, it encodes for the protein known as DNA-binding protein inhibitor ID-4. This protein is known to be involved in the regulation of many cellular processes during both prenatal development and tumorigenesis. This is inclusive of embryonic cellular growth, senescence, cellular differentiation, apoptosis, and as an oncogene in angiogenesis.

MLLT1 Protein-coding gene in the species Homo sapiens

Protein ENL is a protein that in humans is encoded by the MLLT1 gene.

PBX3 Protein found in humans

Pre-B-cell leukemia transcription factor 3 is a protein that in humans is encoded by the PBX3 gene.

NHLH1 Protein-coding gene in the species Homo sapiens

Helix-loop-helix protein 1 is a protein that in humans is encoded by the NHLH1 gene.

TAL2 Protein-coding gene in the species Homo sapiens

T-cell acute lymphocytic leukemia 2, also known as TAL2, is a protein which in humans is encoded by the TAL2 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000104903 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034041 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Mellentin JD, Smith SD, Cleary ML (July 1989). "lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif". Cell. 58 (1): 77–83. doi:10.1016/0092-8674(89)90404-2. PMID   2752424. S2CID   24737263.
  6. "Entrez Gene: LYL1 lymphoblastic leukemia derived sequence 1".
  7. Miyamoto A, Cui X, Naumovski L, Cleary ML (May 1996). "Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells". Molecular and Cellular Biology. 16 (5): 2394–401. doi:10.1128/mcb.16.5.2394. PMC   231228 . PMID   8628307.
  8. Ferrier R, Nougarede R, Doucet S, Kahn-Perles B, Imbert J, Mathieu-Mahul D (January 1999). "Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105". Oncogene. 18 (4): 995–1005. doi: 10.1038/sj.onc.1202374 . PMID   10023675.

Further reading