HMGB4

HMGB4
Identifiers
Aliases	HMGB4 , dJ1007G16.5, high mobility group box 4
External IDs	OMIM: 617285 MGI: 1916567 HomoloGene: 83321 GeneCards: HMGB4
Gene location (Human)
Chr.	Chromosome 1 (human)
End	33,864,791 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	128,260,957 bp
Gene ontology
Molecular function	• GO:0001948 protein binding ; • DNA binding ; • transcription factor binding ; • DNA binding, bending ;
Cellular component	• nucleus ; • chromosome ; • cytoplasm ;
Biological process	• activation of innate immune response ; • DNA recombination ; • chromatin remodeling ; • regulation of transcription by RNA polymerase II ; • regulation of signaling receptor activity ; • positive regulation of autophagy ; • developmental process ; • positive regulation of interleukin-6 production ; • positive regulation of tumor necrosis factor production ; • positive regulation of innate immune response ; • positive regulation of transcription by RNA polymerase II ; • cell chemotaxis ; • positive regulation of ERK1 and ERK2 cascade ; • positive regulation of NIK/NF-kappaB signaling ;
	Sources:Amigo / QuickGO
Orthologs
	127540
	69317
	ENSG00000176256
	ENSMUSG00000048686
	Q8WW32
	Q6P8W9
	NM_145205 ; NM_001352984 ; NM_001379301
	NM_027036
	NP_660206 ; NP_001339913 ; NP_001366230
	NP_081312
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 01, 2021

High mobility group protein B4 is a transcription factor that in humans is encoded by the HMGB4 gene.^[5]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000176256 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048686 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: high-mobility group box 4".

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Sogayar MC, Camargo AA, Bettoni F, et al. (2004). "A transcript finishing initiative for closing gaps in the human transcriptome". Genome Res. 14 (7): 1413–23. doi:10.1101/gr.2111304. PMC 442158 . PMID 15197164.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000176256 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048686 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: high-mobility group box 4".

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HMGB4

Contents

See also

Related Research Articles

References

Further reading