ETV4

Last updated
ETV4
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ETV4 , E1A-F, E1AF, PEA3, PEAS3, ETS variant 4, ETS variant transcription factor 4
External IDs OMIM: 600711; MGI: 99423; HomoloGene: 1504; GeneCards: ETV4; OMA:ETV4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_008815
NM_001316365
NM_001316366

RefSeq (protein)

NP_001303294
NP_001303295
NP_032841

Location (UCSC) Chr 17: 43.53 – 43.58 Mb Chr 11: 101.66 – 101.68 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ETS translocation variant 4 (ETV4), also known as polyoma enhancer activator 3 (PEA3), is a member of the PEA3 subfamily of Ets transcription factors. [5] [6] [7]

Contents

Disease marker

Two variants of a disease associated with ETV4 is Ewing Sarcoma and Extraosseous Ewing's Sarcoma. While both are cancerous tumors, the former grows in the bones most commonly affecting the arms, legs, hips, and spine, while the later affects the soft tissue in the chest, foot, pelvis and spine.

Related Research Articles

<span class="mw-page-title-main">EP300</span> Protein-coding gene in the species Homo sapiens

Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 also known as EP300 or p300 is an enzyme that, in humans, is encoded by the EP300 gene. It functions as histone acetyltransferase that regulates transcription of genes via chromatin remodeling by allowing histone proteins to wrap DNA less tightly. This enzyme plays an essential role in regulating cell growth and division, prompting cells to mature and assume specialized functions (differentiate), and preventing the growth of cancerous tumors. The p300 protein appears to be critical for normal development before and after birth.

<span class="mw-page-title-main">Transcription factor Jun</span> Mammalian protein found in Homo sapiens

Transcription factor Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the JUN gene. c-jun was the first oncogenic transcription factor discovered. The proto-oncogene c-Jun is the cellular homolog of the viral oncoprotein v-jun. The viral homolog v-jun was discovered in avian sarcoma virus 17 and was named for ju-nana, the Japanese word for 17. The human JUN encodes a protein that is highly similar to the viral protein, which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.

<span class="mw-page-title-main">Ewing sarcoma</span> Type of cancer

Ewing sarcoma is a type of pediatric cancer that forms in bone or soft tissue. Symptoms may include swelling and pain at the site of the tumor, fever, and a bone fracture. The most common areas where it begins are the legs, pelvis, and chest wall. In about 25% of cases, the cancer has already spread to other parts of the body at the time of diagnosis. Complications may include a pleural effusion or paraplegia.

<span class="mw-page-title-main">RUNX3</span> Protein-coding gene in humans

Runt-related transcription factor 3 is a protein that in humans is encoded by the RUNX3 gene.

<span class="mw-page-title-main">FLI1</span> Protein-coding gene in the species Homo sapiens

Friend leukemia integration 1 transcription factor (FLI1), also known as transcription factor ERGB, is a protein that in humans is encoded by the FLI1 gene, which is a proto-oncogene.

<span class="mw-page-title-main">ATF1</span> Protein-coding gene in humans

Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.

<span class="mw-page-title-main">GABPA</span> Protein-coding gene in the species Homo sapiens

GA-binding protein alpha chain is a protein that in humans is encoded by the GABPA gene.

<span class="mw-page-title-main">RNA-binding protein EWS</span> Human protein and coding gene

RNA-binding protein EWS is a protein that in humans is encoded by the EWSR1 gene on human chromosome 22, specifically 22q12.2. It is one of 3 proteins in the FET protein family.

<span class="mw-page-title-main">SNAI1</span> Protein

Zinc finger protein SNAI1 is a protein that in humans is encoded by the SNAI1 gene. Snail is a family of transcription factors that promote the repression of the adhesion molecule E-cadherin to regulate epithelial to mesenchymal transition (EMT) during embryonic development.

<i>ERG</i> (gene) Protein-coding gene in the species Homo sapiens

ERG is an oncogene. ERG is a member of the ETS family of transcription factors. The ERG gene encodes for a protein, also called ERG, that functions as a transcriptional regulator. Genes in the ETS family regulate embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis.

<span class="mw-page-title-main">ETV1</span> Protein-coding gene in the species Homo sapiens

ETS translocation variant 1 is a protein that in humans is encoded by the ETV1 gene.

<span class="mw-page-title-main">SPDEF</span> Protein-coding gene in the species Homo sapiens

SAM pointed domain-containing Ets transcription factor is a protein that in humans is encoded by the SPDEF gene.

<span class="mw-page-title-main">SOX6</span> Protein-coding gene in the species Homo sapiens

Transcription factor SOX-6 is a protein that in humans is encoded by the SOX6 gene.

<span class="mw-page-title-main">E4F1</span> Protein-coding gene in the species Homo sapiens

Transcription factor E4F1 is a protein that in humans is encoded by the E4F1 gene.

<span class="mw-page-title-main">ELF5</span> Protein-coding gene

E74-like factor 5 , is a gene found in both mice and humans. In humans it is also called ESE2.

<span class="mw-page-title-main">ELF4</span> Protein-coding gene in humans

ETS-related transcription factor Elf-4 is a protein that in humans is encoded by the ELF4 gene.

<i>EHF</i> (gene) Protein-coding gene in the species Homo sapiens

ETS homologous factor is a protein that in humans is encoded by the EHF gene. This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be associated with asthma susceptibility. This protein may be involved in epithelial differentiation and carcinogenesis.

<span class="mw-page-title-main">BHLHE41</span> Protein-coding gene in humans

"Basic helix-loop-helix family, member e41", or BHLHE41, is a gene that encodes a basic helix-loop-helix transcription factor repressor protein in various tissues of both humans and mice. It is also known as DEC2, hDEC2, and SHARP1, and was previously known as "basic helix-loop-helix domain containing, class B, 3", or BHLHB3. BHLHE41 is known for its role in the circadian molecular mechanisms that influence sleep quantity as well as its role in immune function and the maturation of T helper type 2 cell lineages associated with humoral immunity.

<span class="mw-page-title-main">ETS transcription factor family</span> Protein family

In the field of molecular biology, the ETSfamily is one of the largest families of transcription factors and is unique to animals. There are 28 genes in humans, 27 in the mouse, 10 in Caenorhabditis elegans and 9 in Drosophila. The founding member of this family was identified as a gene transduced by the leukemia virus, E26. The members of the family have been implicated in the development of different tissues as well as cancer progression.

The FET protein family consists of three similarly structured and functioning proteins. They and the genes in the FET gene family which encode them are: 1) the EWSR1 protein encoded by the EWSR1 gene located at band 12.2 of the long arm of chromosome 22; 2) the FUS protein encoded by the FUS gene located at band 16 on the short arm of chromosome 16; and 3) the TAF15 protein encoded by the TAF15 gene located at band 12 on the long arm of chromosome 7 The FET in this protein family's name derives from the first letters of FUS, EWSR1, and TAF15.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000175832 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000017724 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Isobe M, Yamagishi F, Yoshida K, Higashino F, Fujinaga K (Jul 1995). "Assignment of the ets-related transcription factor E1A-F gene (ETV4) to human chromosome region 17q21". Genomics. 28 (2): 357–9. doi:10.1006/geno.1995.1158. PMID   8530053.
  6. "Entrez Gene: ETV4 Ets variant gene 4 (E1A enhancer binding protein, E1AF)".
  7. "ETV4 Gene - GeneCards | ETV4 Protein | ETV4 Antibody". www.genecards.org. Retrieved 2019-10-20.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.