IRX4

IRX4
Identifiers
Aliases	IRX4 , IRXA3, iroquois homeobox 4
External IDs	OMIM: 606199 MGI: 1355275 HomoloGene: 9485 GeneCards: IRX4
Gene location (Human)
Chr.	Chromosome 5 (human)
End	1,887,236 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	73,417,727 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; hair follicle; ; left ventricle; ; minor salivary gland; ; vagina; ; right ventricle; ; nipple; ; prostate; ; lactiferous duct; ; gums;
	Top expressed in
	lip; ; ventricle; ; atrioventricular canal; ; endocardial cushion; ; myocardium of ventricle; ; cardiac muscles; ; right ventricle; ; atrioventricular valve; ; upper lip; ; hair follicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding ; DNA binding ; DNA-binding transcription factor activity, RNA polymerase II-specific ;
Cellular component	nucleus ;
Biological process	heart development ; regulation of transcription, DNA-templated ; establishment of animal organ orientation ; regulation of transcription by RNA polymerase II ;
	Sources:Amigo / QuickGO
Orthologs
	50805
	50916
	ENSG00000113430
	ENSMUSG00000021604
	P78413
	Q9QY61
	NM_016358 ; NM_001278632 ; NM_001278633 ; NM_001278634 ; NM_001278635 Contents Function ; References ; Further reading ;
	NM_018885
	NP_001265561 ; NP_001265562 ; NP_001265563 ; NP_001265564 ; NP_057442
	NP_061373
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 17, 2022

Iroquois-class homeodomain protein IRX-4, also known as Iroquois homeobox protein 4, is a protein that in humans is encoded by the IRX4 gene.^[5]^[6]

Function

IRX4 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.^[5]

Related Research Articles

Homeobox protein Hox-A7 is a protein that in humans is encoded by the HOXA7 gene.

Homeobox protein DLX-3 is a protein that in humans is encoded by the DLX3 gene.

Homeobox protein DLX-4 is a protein that in humans is encoded by the DLX4 gene.

Homeobox protein Hox-D11 is a protein that in humans is encoded by the HOXD11 gene.

Homeobox protein Hox-D12 is a protein that in humans is encoded by the HOXD12 gene.

Homeobox protein Emx2 is a protein that in humans is encoded by the EMX2 gene.

Homeobox protein Hox-D1 is a protein that in humans is encoded by the HOXD1 gene.

Homeobox protein Hox-D8 is a protein that in humans is encoded by the HOXD8 gene.

Homeobox protein Hox-C11 is a protein that in humans is encoded by the HOXC11 gene.

Homeobox protein Meis2 is a protein that in humans is encoded by the MEIS2 gene.

Paired mesoderm homeobox protein 2 is a protein that in humans is encoded by the PRRX2 gene.

Homeobox protein SIX4 is a protein that in humans is encoded by the SIX4 gene.

Iroquois-class homeodomain protein IRX-3, also known as Iroquois homeobox protein 3, is a protein that in humans is encoded by the IRX3 gene.

Iroquois-class homeodomain protein IRX-1, also known as Iroquois homeobox protein 1, is a protein that in humans is encoded by the IRX1 gene. All members of the Iroquois (IRO) family of proteins share two highly conserved features, encoding both a homeodomain and a characteristic IRO sequence motif. Members of this family are known to play numerous roles in early embryo patterning. IRX1 has also been shown to act as a tumor suppressor gene in several forms of cancer.

Iroquois-class homeodomain protein IRX-2, also known as Iroquois homeobox protein 2, is a protein that in humans is encoded by the IRX2 gene.

Iroquois-class homeodomain protein IRX-5, also known as Iroquois homeobox protein 5, is a protein that in humans is encoded by the IRX5 gene.

Iroquois-class homeodomain protein IRX-6, also known as Iroquois homeobox protein 6, is a protein that in humans is encoded by the IRX6 gene.

Homeobox protein Mohawk, also known as iroquois homeobox protein-like 1, is a protein that in humans is encoded by the MKX gene. MKX is a member of an Iroquois (IRX) family-related class of 'three-amino acid loop extension' (TALE) atypical homeobox proteins characterized by 3 additional amino acids in the loop region between helix I and helix II of the homeodomain.

Gap junction delta-2 (GJD2), also known as connexin-36 (Cx36) or gap junction alpha-9 (GJA9), is a protein that in humans is encoded by the GJD2 gene.

Short-stature homeobox 2, also known as homeobox protein Og12X or paired-related homeobox protein SHOT, is a protein that in humans is encoded by the SHOX2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000113430 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021604 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: iroquois homeobox 4".
↑ Bruneau BG, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman JG, Seidman CE (January 2000). "Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand". Dev. Biol. 217 (2): 266–77. doi: 10.1006/dbio.1999.9548 . PMID 10625552.

Lewis MT, Ross S, Strickland PA, et al. (1999). "Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast". Cell Tissue Res. 296 (3): 549–54. doi:10.1007/s004410051316. PMID 10370142. S2CID 37046813.
Wang GF, Nikovits W, Bao ZZ, Stockdale FE (2001). "Irx4 forms an inhibitory complex with the vitamin D and retinoic X receptors to regulate cardiac chamber-specific slow MyHC3 expression". J. Biol. Chem. 276 (31): 28835–41. doi: 10.1074/jbc.M103716200 . PMID 11382777.
Bayrak F, Kömürcü-Bayrak E, Mutlu B, et al. (2008). "Genetic analysis of the Irx4 gene in hypertrophic cardiomyopathy". Turk Kardiyol Dern Ars. 36 (2): 90–5. PMID 18497553.
Cirulli ET, Kasperavičiūtė D, Attix DK, et al. (2010). "Common genetic variation and performance on standardized cognitive tests". European Journal of Human Genetics. 18 (7): 815–820. doi:10.1038/ejhg.2010.2. PMC 2987367 . PMID 20125193.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000113430 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021604 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: iroquois homeobox 4".

[pmid10625552-6] Bruneau BG, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman JG, Seidman CE (January 2000). "Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand". Dev. Biol. 217 (2): 266–77. doi: 10.1006/dbio.1999.9548 . PMID 10625552.

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IRX4

Contents

Function

Related Research Articles

References

Further reading