IRX4

IRX4
Identifiers
Aliases	IRX4 , IRXA3, iroquois homeobox 4
External IDs	OMIM: 606199; MGI: 1355275; HomoloGene: 9485; GeneCards: IRX4; OMA:IRX4 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5p15.33 Start 1,877,413 bp [1] End 1,887,236 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 C1 Start 73,408,598 bp [2] End 73,417,727 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen apex of heart skin of leg hair follicle gonad left ventricle minor salivary glands vagina right ventricle epithelium of lactiferous gland Top expressed in lip ventricle of the heart atrioventricular canal endocardial cushion myocardium of ventricle cardiac muscles right ventricle atrioventricular valve primordial ventricle upper lip More reference expression data BioGPS n/a
Gene ontology Molecular function sequence-specific DNA binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process heart development regulation of transcription, DNA-templated establishment of animal organ orientation regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50805 50916 Ensembl ENSG00000113430 ENSMUSG00000021604 UniProt P78413 Q9QY61 RefSeq (mRNA) NM_016358 NM_001278632 NM_001278633 NM_001278634 NM_001278635 NM_018885 RefSeq (protein) NP_001265561 NP_001265562 NP_001265563 NP_001265564 NP_057442 NP_061373 Location (UCSC) Chr 5: 1.88 – 1.89 Mb Chr 13: 73.41 – 73.42 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Iroquois-class homeodomain protein IRX-4, also known as Iroquois homeobox protein 4, is a protein that in humans is encoded by the IRX4 gene. ^{[5] [6]}

Function

IRX4 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000113430 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021604 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: iroquois homeobox 4".
6. Bruneau BG, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman JG, Seidman CE (January 2000). "Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand". Dev. Biol. 217 (2): 266–77. doi: 10.1006/dbio.1999.9548 . PMID   10625552.

Further reading

• Lewis MT, Ross S, Strickland PA, et al. (1999). "Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast" . Cell Tissue Res. 296 (3): 549–54. doi:10.1007/s004410051316. PMID   10370142. S2CID   37046813.
• Wang GF, Nikovits W, Bao ZZ, Stockdale FE (2001). "Irx4 forms an inhibitory complex with the vitamin D and retinoic X receptors to regulate cardiac chamber-specific slow MyHC3 expression". J. Biol. Chem. 276 (31): 28835–41. doi: 10.1074/jbc.M103716200 . PMID   11382777.
• Bayrak F, Kömürcü-Bayrak E, Mutlu B, et al. (2008). "Genetic analysis of the Irx4 gene in hypertrophic cardiomyopathy". Turk Kardiyol Dern Ars. 36 (2): 90–5. PMID   18497553.
• Cirulli ET, Kasperavičiūtė D, Attix DK, et al. (2010). "Common genetic variation and performance on standardized cognitive tests". European Journal of Human Genetics. 18 (7): 815–820. doi:10.1038/ejhg.2010.2. PMC   2987367 . PMID   20125193.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.