HOXD10

Last updated
HOXD10
Identifiers
Aliases HOXD10 , HOX4, HOX4D, HOX4E, Hox-4.4, homeobox D10
External IDs OMIM: 142984; MGI: 96202; HomoloGene: 1619; GeneCards: HOXD10; OMA:HOXD10 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002148

NM_013554

RefSeq (protein)

NP_002139

NP_038582

Location (UCSC) Chr 2: 176.11 – 176.12 Mb Chr 2: 74.52 – 74.53 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox D10, also known as HOXD10, is a protein which in humans is encoded by the HOXD10 gene. [5]

Contents

Function

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development.

Clinical significance

Mutations in this gene have been associated with Wilms' tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [5] [ citation needed ]

Regulation

The HOXD10 gene is repressed by the microRNAs miR-10a and miR-10b. [6] [7] [8]

See also

Related Research Articles

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Homeobox protein Hox-A11 is a protein that in humans is encoded by the HOXA11 gene.

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<span class="mw-page-title-main">HOXB4</span> Protein-coding gene in humans

Homeobox protein Hox-B4 is a protein that in humans is encoded by the HOXB4 gene.

<span class="mw-page-title-main">HOXC8</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">HOXD13</span> Protein

Homeobox protein Hox-D13 is a protein that in humans is encoded by the HOXD13 gene. This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms.

<span class="mw-page-title-main">HOXB1</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-B1 is a protein that in humans is encoded by the HOXB1 gene.

<span class="mw-page-title-main">HOXB2</span> Protein-coding gene in humans

Homeobox protein Hox-B2 is a protein that in humans is encoded by the HOXB2 gene.

<span class="mw-page-title-main">HOXB9</span> Protein-coding gene in humans

Homeobox protein Hox-B9 is a protein that in humans is encoded by the HOXB9 gene.

<span class="mw-page-title-main">HOXD3</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-D3 is a protein that in humans is encoded by the HOXD3 gene.

<span class="mw-page-title-main">HOXC4</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C4 is a protein that in humans is encoded by the HOXC4 gene.

<span class="mw-page-title-main">HOXD9</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-D9 is a protein that in humans is encoded by the HOXD9 gene.

<span class="mw-page-title-main">HOXC6</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C6 is a protein that in humans is encoded by the HOXC6 gene. Hox-C6 expression is highest in the fallopian tube and ovary. HoxC6 has been highly expressed in many types of cancers including prostate, breast, and esophageal squamous cell cancer.

<span class="mw-page-title-main">HOXD4</span> Protein-coding gene

Homeobox protein Hox-D4 is a protein that in humans is encoded by the HOXD4 gene.

<span class="mw-page-title-main">HOXC13</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C13 is a protein that in humans is encoded by the HOXC13 gene.

<span class="mw-page-title-main">HOXB8</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-B8 is a protein that in humans is encoded by the HOXB8 gene.

<span class="mw-page-title-main">HOXC9</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C9 is a protein that in humans is encoded by the HOXC9 gene.

<span class="mw-page-title-main">HOXC5</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C5 is a protein that in humans is encoded by the HOXC5 gene.

<span class="mw-page-title-main">HOXC12</span> Protein-coding gene in the species Homo sapiens

Homeobox C12 is a protein that in humans is encoded by the HOXC12 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000128710 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050368 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: HOXD10 homeobox D10".
  6. Lund AH (Feb 2010). "miR-10 in development and cancer". Cell Death and Differentiation. 17 (2): 209–14. doi: 10.1038/cdd.2009.58 . PMID   19461655.
  7. Ma L, Teruya-Feldstein J, Weinberg RA (Oct 2007). "Tumour invasion and metastasis initiated by microRNA-10b in breast cancer". Nature. 449 (7163): 682–8. Bibcode:2007Natur.449..682M. doi:10.1038/nature06174. PMID   17898713. S2CID   4421050.
  8. Han L, Witmer PD, Casey E, Valle D, Sukumar S (Aug 2007). "DNA methylation regulates MicroRNA expression". Cancer Biology & Therapy. 6 (8): 1284–8. doi: 10.4161/cbt.6.8.4486 . PMID   17660710.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.