Homeobox D10, also known as HOXD10, is a protein which in humans is encoded by the HOXD10 gene. [5]
This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development.
Mutations in this gene have been associated with Wilms' tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [5] [ citation needed ]
The HOXD10 gene is repressed by the microRNAs miR-10a and miR-10b. [6] [7] [8]
Homeobox protein Hox-B7 is a protein that in humans is encoded by the HOXB7 gene.
Homeobox protein Hox-B6 is a protein that in humans is encoded by the HOXB6 gene.
Homeobox protein Hox-A11 is a protein that in humans is encoded by the HOXA11 gene.
Homeobox protein Hox-B5 is a protein that in humans is encoded by the HOXB5 gene.
Homeobox protein Hox-B4 is a protein that in humans is encoded by the HOXB4 gene.
Homeobox protein Hox-C8 is a protein that in humans is encoded by the HOXC8 gene.
Homeobox protein Hox-D13 is a protein that in humans is encoded by the HOXD13 gene. This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms.
Homeobox protein Hox-B1 is a protein that in humans is encoded by the HOXB1 gene.
Homeobox protein Hox-B2 is a protein that in humans is encoded by the HOXB2 gene.
Homeobox protein Hox-B9 is a protein that in humans is encoded by the HOXB9 gene.
Homeobox protein Hox-D3 is a protein that in humans is encoded by the HOXD3 gene.
Homeobox protein Hox-C4 is a protein that in humans is encoded by the HOXC4 gene.
Homeobox protein Hox-D9 is a protein that in humans is encoded by the HOXD9 gene.
Homeobox protein Hox-C6 is a protein that in humans is encoded by the HOXC6 gene. Hox-C6 expression is highest in the fallopian tube and ovary. HoxC6 has been highly expressed in many types of cancers including prostate, breast, and esophageal squamous cell cancer.
Homeobox protein Hox-D4 is a protein that in humans is encoded by the HOXD4 gene.
Homeobox protein Hox-C13 is a protein that in humans is encoded by the HOXC13 gene.
Homeobox protein Hox-B8 is a protein that in humans is encoded by the HOXB8 gene.
Homeobox protein Hox-C9 is a protein that in humans is encoded by the HOXC9 gene.
Homeobox protein Hox-C5 is a protein that in humans is encoded by the HOXC5 gene.
Homeobox C12 is a protein that in humans is encoded by the HOXC12 gene.
{{cite journal}}
: CS1 maint: DOI inactive as of August 2024 (link)This article incorporates text from the United States National Library of Medicine, which is in the public domain.