Hepatocyte nuclear factor 4 gamma

Last updated
HNF4G
Protein HNF4G PDB 1lv2.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases HNF4G , NR2A2, NR2A3, Hepatocyte nuclear factor 4 gamma
External IDs OMIM: 605966; MGI: 1353604; HomoloGene: 37886; GeneCards: HNF4G; OMA:HNF4G - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004133
NM_001330561

NM_013920
NM_001395870

RefSeq (protein)

NP_001317490
NP_004124

NP_038948
NP_001382799

Location (UCSC) Chr 8: 75.41 – 75.57 Mb Chr 3: 3.57 – 3.72 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Hepatocyte nuclear factor 4 gamma (HNF4G) also known as NR2A2 (nuclear receptor subfamily 2, group A, member 2) is a nuclear receptor that in humans is encoded by the HNF4Ggene. [5] [6] [7]

Contents

Function

HNF4G is a transcription factor that has been shown to play a significant role in intestinal epithelial cell differentiation and function. Research using integrative multi-omics analysis of intestinal organoid differentiation has revealed that HNF4G acts as a master regulator of gene regulation in differentiation towards the enterocyte lineage. [8] The study demonstrated widespread binding to promoters and enhancers that are activated in enterocytes, and that the loss of Hnf4g results in a partial loss of enterocyte differentiation, indicating its importance in maintaining the enterocyte lineage.

See also

Related Research Articles

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000164749 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000017688 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: HNF4G hepatocyte nuclear factor 4, gamma".
  6. Drewes T, Senkel S, Holewa B, Ryffel GU (March 1996). "Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes". Molecular and Cellular Biology. 16 (3): 925–931. doi:10.1128/mcb.16.3.925. PMC   231074 . PMID   8622695.
  7. Wisely GB, Miller AB, Davis RG, Thornquest AD, Johnson R, Spitzer T, et al. (September 2002). "Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids". Structure. 10 (9): 1225–1234. doi: 10.1016/S0969-2126(02)00829-8 . PMID   12220494.
  8. Lindeboom RG, van Voorthuijsen L, Oost KC, Rodríguez-Colman MJ, Luna-Velez MV, Furlan C, et al. (June 2018). "Integrative multi-omics analysis of intestinal organoid differentiation". Molecular Systems Biology. 14 (6): e8227. doi:10.15252/msb.20188227. PMC   6018986 . PMID   29945941.

Further reading