Hepatocyte nuclear factor 4 gamma

HNF4G
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LV2
Identifiers
Aliases	HNF4G , NR2A2, NR2A3, Hepatocyte nuclear factor 4 gamma
External IDs	OMIM: 605966; MGI: 1353604; HomoloGene: 37886; GeneCards: HNF4G; OMA:HNF4G - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q21.13 Start 75,407,914 bp [1] End 75,566,834 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 A1 Start 3,573,090 bp [2] End 3,723,112 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa duodenum rectum mucosa of colon mucosa of ileum mucosa of sigmoid colon mucosa of transverse colon gallbladder right lobe of liver body of pancreas Top expressed in duodenum jejunum urethra ileum epithelium of small intestine male urethra right kidney proximal tubule intestinal villus migratory enteric neural crest cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity steroid hormone receptor activity sequence-specific DNA binding DNA binding nuclear receptor activity zinc ion binding metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm Biological process regulation of transcription by RNA polymerase II intracellular receptor signaling pathway transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated transcription, DNA-templated steroid hormone mediated signaling pathway positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3174 30942 Ensembl ENSG00000164749 ENSMUSG00000017688 UniProt Q14541 Q9WUU6 RefSeq (mRNA) NM_004133 NM_001330561 NM_013920 NM_001395870 RefSeq (protein) NP_001317490 NP_004124 NP_038948 NP_001382799 Location (UCSC) Chr 8: 75.41 – 75.57 Mb Chr 3: 3.57 – 3.72 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Hepatocyte nuclear factor 4 gamma (HNF4G) also known as NR2A2 (nuclear receptor subfamily 2, group A, member 2) is a nuclear receptor that in humans is encoded by the HNF4Ggene. ^{[5] [6] [7]}

Function

HNF4G is a transcription factor that has been shown to play a significant role in intestinal epithelial cell differentiation and function. Research using integrative multi-omics analysis of intestinal organoid differentiation has revealed that HNF4G acts as a master regulator of gene regulation in differentiation towards the enterocyte lineage. ^[8] The study demonstrated widespread binding to promoters and enhancers that are activated in enterocytes, and that the loss of Hnf4g results in a partial loss of enterocyte differentiation, indicating its importance in maintaining the enterocyte lineage.

See also

• Hepatocyte nuclear factor 4
• Hepatocyte nuclear factors

References

1. GRCh38: Ensembl release 89: ENSG00000164749 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000017688 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: HNF4G hepatocyte nuclear factor 4, gamma".
6. Drewes T, Senkel S, Holewa B, Ryffel GU (March 1996). "Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes". Molecular and Cellular Biology. 16 (3): 925–931. doi:10.1128/mcb.16.3.925. PMC   231074 . PMID   8622695.
7. Wisely GB, Miller AB, Davis RG, Thornquest AD, Johnson R, Spitzer T, et al. (September 2002). "Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids". Structure. 10 (9): 1225–1234. doi: 10.1016/S0969-2126(02)00829-8 . PMID   12220494.
8. Lindeboom RG, van Voorthuijsen L, Oost KC, Rodríguez-Colman MJ, Luna-Velez MV, Furlan C, et al. (June 2018). "Integrative multi-omics analysis of intestinal organoid differentiation". Molecular Systems Biology. 14 (6): e8227. doi:10.15252/msb.20188227. PMC   6018986 . PMID   29945941.

Further reading

• Plengvidhya N, Antonellis A, Wogan LT, Poleev A, Borgschulze M, Warram JH, et al. (October 1999). "Hepatocyte nuclear factor-4gamma: cDNA sequence, gene organization, and mutation screening in early-onset autosomal-dominant type 2 diabetes". Diabetes. 48 (10): 2099–2102. doi:10.2337/diabetes.48.10.2099. PMID   10512380.
• Ozeki T, Takahashi Y, Nakayama K, Funayama M, Nagashima K, Kodama T, et al. (January 2003). "Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers". Pharmacogenetics. 13 (1): 49–53. doi:10.1097/00008571-200301000-00007. PMID   12544512.

External links

• FactorBook HNF4G