EBF1

EBF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LYR, 3MQI
Identifiers
Aliases	EBF1 , COE1, EBF, O/E-1, OLF1, early B-cell factor 1, early B cell factor 1, EBF transcription factor 1
External IDs	OMIM: 164343 MGI: 95275 HomoloGene: 7297 GeneCards: EBF1
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q33.3 Start 158,695,916 bp [1] End 159,099,916 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 B1.1|11 26.45 cM Start 44,617,317 bp [2] End 45,008,091 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in synovial joint synovial membrane Achilles tendon oocyte parietal pleura vena cava spinal ganglia superficial temporal artery urethra saphenous vein Top expressed in external carotid artery internal carotid artery trigeminal ganglion superior cervical ganglion spinal ganglia neural tube ankle subcutaneous adipose tissue brown adipose tissue stria vascularis More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein binding metal ion binding DNA-binding transcription factor activity protein dimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific C2H2 zinc finger domain binding DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component nucleus Biological process multicellular organism development regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1879 13591 Ensembl ENSG00000164330 ENSMUSG00000057098 UniProt Q9UH73 Q07802 RefSeq (mRNA) NM_001290360 NM_024007 NM_182708 NM_001324101 NM_001324103 NM_001324106 NM_001324107 NM_001324108 NM_001324109 NM_001324111 NM_001364155 NM_001364156 NM_001364157 NM_001364158 NM_001364159 NM_001290709 NM_001290710 NM_001290711 NM_007897 RefSeq (protein) NP_001277289 NP_001311030 NP_001311032 NP_001311035 NP_001311036 NP_001311037 NP_001311038 NP_001311040 NP_076870 NP_874367 NP_001351084 NP_001351085 NP_001351086 NP_001351087 NP_001351088 NP_001277638 NP_001277639 NP_001277640 NP_031923 NP_001349498 NP_001349500 NP_001349503 NP_001349504 NP_001349505 NP_001349506 NP_001349507 NP_001349508 Location (UCSC) Chr 5: 158.7 – 159.1 Mb Chr 11: 44.62 – 45.01 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transcription factor COE1 is a protein that in humans is encoded by the EBF1 gene. EBF1 stands for Early B-Cell Factor 1. ^{[5] [6] [7]}

EBF1 controls the expression of key proteins required for B cell differentiation, signal transduction and function. ^{[8] [9]} The crucial role of this factor is shown in the regulation of expression of SLAM family co-receptors in B-cells. ^[10] In addition, EBF1 is also noted for its role in chondrogenic differentiation in limb bud mesenchymal progenitor cells. ^[11]

Interactions

EBF1 has been shown to interact with ZNF423 ^[12] and CREB binding protein. ^[13]

References

1. GRCh38: Ensembl release 89: ENSG00000164330 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000057098 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Symbol Report: EBF1". HUGO Gene Nomenclature Committee.
6. Milatovich A, Qiu RG, Grosschedl R, Francke U (Jul 1994). "Gene for a tissue-specific transcriptional activator (EBF or Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory neurons, is located on human chromosome 5, band q34, and proximal mouse chromosome 11". Mamm. Genome. 5 (4): 211–5. doi:10.1007/BF00360547. PMID   8012110. S2CID   19839522.
7. "Entrez Gene: EBF1 early B-cell factor 1".
8. Treiber T, Mandel EM, Pott S, Györy I, Firner S, Liu ET, Grosschedl R (2010). "Early B Cell Factor 1 Regulates B Cell Gene Networks by Activation, Repression, and Transcription- Independent Poising of Chromatin". Immunity. 32 (5): 714–725. doi: 10.1016/j.immuni.2010.04.013 . PMID   20451411.
9. Hagman J, Ramírez J, Lukin K (2012-01-01). "B Lymphocyte Lineage Specification, Commitment and Epigenetic Control of Transcription by Early B Cell Factor 1". Epigenetic Regulation of Lymphocyte Development. Current Topics in Microbiology and Immunology. Vol. 356. pp. 17–38. doi:10.1007/82_2011_139. ISBN   978-3-642-24102-4. ISSN   0070-217X. PMC   3925327 . PMID   21735360.
10. Schwartz AM, Putlyaeva LV, Covich M, Klepikova AV, Akulich KA, Vorontsov IE, Korneev KV, Dmitriev SE, Polanovsky OL (2016-10-01). "Early B-cell factor 1 (EBF1) is critical for transcriptional control of SLAMF1 gene in human B cells". Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1859 (10): 1259–1268. doi:10.1016/j.bbagrm.2016.07.004. PMID   27424222.
11. Takács R, Vágó J, Póliska S, Pushparaj PN, Ducza L, Kovács P, Jin EJ, Barrett-Jolley R, Zákány R, Matta C (2023-03-29). "The temporal transcriptomic signature of cartilage formation". Nucleic Acids Research. 51 (8): 3590–3617. doi:10.1093/nar/gkad210. ISSN   1362-4962. PMC   10164575 . PMID   36987858.
12. Tsai RY, Reed RR (Jun 1997). "Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development". J. Neurosci. 17 (11): 4159–69. doi: 10.1523/JNEUROSCI.17-11-04159.1997 . PMC   6573535 . PMID   9151733.
13. Zhao F, McCarrick-Walmsley R, Akerblad P, Sigvardsson M, Kadesch T (Jun 2003). "Inhibition of p300/CBP by early B-cell factor" (PDF). Mol. Cell. Biol. 23 (11): 3837–46. doi:10.1128/MCB.23.11.3837-3846.2003. PMC   155219 . PMID   12748286.

Further reading

• Liberg D, Sigvardsson M, Akerblad P (2002). "The EBF/Olf/Collier family of transcription factors: regulators of differentiation in cells originating from all three embryonal germ layers". Mol. Cell. Biol. 22 (24): 8389–97. doi:10.1128/MCB.22.24.8389-8397.2002. PMC   139877 . PMID   12446759.
• Hagman J, Gutch MJ, Lin H, Grosschedl R (1995). "EBF contains a novel zinc coordination motif and multiple dimerization and transcriptional activation domains". EMBO J. 14 (12): 2907–16. doi:10.1002/j.1460-2075.1995.tb07290.x. PMC   398409 . PMID   7796816.
• Wang MM, Reed RR (1993). "Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast". Nature. 364 (6433): 121–6. Bibcode:1993Natur.364..121W. doi:10.1038/364121a0. PMID   8321284. S2CID   4309685.
• Hagman J, Belanger C, Travis A, Turck CW, Grosschedl R (1993). "Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression". Genes Dev. 7 (5): 760–73. doi: 10.1101/gad.7.5.760 . PMID   8491377.
• Travis A, Hagman J, Hwang L, Grosschedl R (1993). "Purification of early-B-cell factor and characterization of its DNA-binding specificity". Mol. Cell. Biol. 13 (6): 3392–400. doi:10.1128/MCB.13.6.3392. PMC   359803 . PMID   8497258.
• Tsai RY, Reed RR (1997). "Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development". J. Neurosci. 17 (11): 4159–69. doi: 10.1523/JNEUROSCI.17-11-04159.1997 . PMC   6573535 . PMID   9151733.
• Gisler R, Jacobsen SE, Sigvardsson M (2000). "Cloning of human early B-cell factor and identification of target genes suggest a conserved role in B-cell development in man and mouse". Blood. 96 (4): 1457–64. doi: 10.1182/blood.V96.4.1457 . PMID   10942392.
• Gisler R, Sigvardsson M (2002). "The human V-preB promoter is a target for coordinated activation by early B cell factor and E47". J. Immunol. 168 (10): 5130–8. doi: 10.4049/jimmunol.168.10.5130 . PMID   11994467.
• Smith EM, Gisler R, Sigvardsson M (2002). "Cloning and characterization of a promoter flanking the early B cell factor (EBF) gene indicates roles for E-proteins and autoregulation in the control of EBF expression". J. Immunol. 169 (1): 261–70. doi: 10.4049/jimmunol.169.1.261 . PMID   12077253.
• Zhao F, McCarrick-Walmsley R, Akerblad P, Sigvardsson M, Kadesch T (2003). "Inhibition of p300/CBP by early B-cell factor". Mol. Cell. Biol. 23 (11): 3837–46. doi:10.1128/MCB.23.11.3837-3846.2003. PMC   155219 . PMID   12748286.
• Merluzzi S, Moretti M, Altamura S, Zwollo P, Sigvardsson M, Vitale G, Pucillo C (2004). "CD40 stimulation induces Pax5/BSAP and EBF activation through a APE/Ref-1-dependent redox mechanism". J. Biol. Chem. 279 (3): 1777–86. doi: 10.1074/jbc.M305418200 . PMID   14594818.
• Bond HM, Mesuraca M, Carbone E, Bonelli P, Agosti V, Amodio N, De Rosa G, Di Nicola M, Gianni AM, Moore MA, Hata A, Grieco M, Morrone G, Venuta S (2004). "Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells". Blood. 103 (6): 2062–70. doi: 10.1182/blood-2003-07-2388 . PMID   14630787.
• Smith EM, Akerblad P, Kadesch T, Axelson H, Sigvardsson M (2005). "Inhibition of EBF function by active Notch signaling reveals a novel regulatory pathway in early B-cell development". Blood. 106 (6): 1995–2001. doi: 10.1182/blood-2004-12-4744 . PMID   15920012.
• Akerblad P, Månsson R, Lagergren A, Westerlund S, Basta B, Lind U, Thelin A, Gisler R, Liberg D, Nelander S, Bamberg K, Sigvardsson M (2005). "Gene expression analysis suggests that EBF-1 and PPARgamma2 induce adipogenesis of NIH-3T3 cells with similar efficiency and kinetics". Physiol. Genomics. 23 (2): 206–16. doi:10.1152/physiolgenomics.00015.2005. PMID   16106032. S2CID   42168486.
• Martínez A, Mas A, de las Heras V, Arroyo R, Fernández-Arquero M, de la Concha EG, Urcelay E (2005). "Early B-cell Factor gene association with multiple sclerosis in the Spanish population". BMC Neurol. 5: 19. doi: 10.1186/1471-2377-5-19 . PMC   1291372 . PMID   16255771.
• Roessler S, Györy I, Imhof S, Spivakov M, Williams RR, Busslinger M, Fisher AG, Grosschedl R (2007). "Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5". Mol. Cell. Biol. 27 (2): 579–94. doi:10.1128/MCB.01192-06. PMC   1800812 . PMID   17101802.

External links

• FactorBook EBF1