TLX1

TLX1
Identifiers
Aliases	TLX1 , HOX11, TCL3, T-cell leukemia homeobox 1, T cell leukemia homeobox 1
External IDs	OMIM: 186770 MGI: 98769 HomoloGene: 4031 GeneCards: TLX1
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q24.31 Start 101,131,300 bp [1] End 101,137,789 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19 C3|19 38.45 cM Start 45,139,119 bp [2] End 45,145,382 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen minor salivary gland right lobe of liver duodenum thymus ventricle left ventricle atrium right atrium rectum Top expressed in dorsal mesentery tongue middle ear submandibular gland outer ear auricle female urethra male urethra Eustachian tube spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity Cellular component nucleus Biological process multicellular organism development regulation of transcription, DNA-templated transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3195 21908 Ensembl ENSG00000107807 ENSMUSG00000025215 UniProt P31314 P43345 RefSeq (mRNA) NM_001195517 NM_005521 NM_021901 RefSeq (protein) NP_001182446 NP_005512 n/a Location (UCSC) Chr 10: 101.13 – 101.14 Mb Chr 19: 45.14 – 45.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

T-cell leukemia homeobox protein 1 is a protein that in humans is encoded by the TLX1 gene, which was initially named HOX11. ^{[5] [6] [7] [8] [9]}

Interactions

TLX1 has been shown to interact with PPP1CC, ^[10] PPP2CB ^[10] and PPP2CA. ^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000107807 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025215 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hatano M, Roberts CW, Minden M, Crist WM, Korsmeyer SJ (Jul 1991). "Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia". Science. 253 (5015): 79–82. Bibcode:1991Sci...253...79H. doi:10.1126/science.1676542. PMID   1676542.
6. McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID   1973146.
7. "Entrez Gene: TLX1 T-cell leukemia homeobox 1".
8. Kennedy MA, Gonzalez-Sarmiento R, Kees UR, Lampert F, Dear N, Boehm T, Rabbitts TH (Oct 1991). "HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24". Proceedings of the National Academy of Sciences of the United States of America. 88 (20): 8900–4. Bibcode:1991PNAS...88.8900K. doi: 10.1073/pnas.88.20.8900 . PMC   52618 . PMID   1681546.
9. Dubé ID, Kamel-Reid S, Yuan CC, Lu M, Wu X, Corpus G, Raimondi SC, Crist WM, Carroll AJ, Minowada J (Dec 1991). "A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14)". Blood. 78 (11): 2996–3003. doi: 10.1182/blood.V78.11.2996.2996 . PMID   1683261.
10. Kawabe T, Muslin AJ, Korsmeyer SJ (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature. 385 (6615): 454–8. Bibcode:1997Natur.385..454K. doi:10.1038/385454a0. PMID   9009195. S2CID   608633.

Further reading

• Allen TD, Zhu YX, Hawley TS, Hawley RG (Oct 2000). "TALE homeoproteins as HOX11-interacting partners in T-cell leukemia". Leukemia & Lymphoma. 39 (3–4): 241–56. doi:10.3109/10428190009065824. PMID   11342305. S2CID   27407074.
• Lu M, Zhang N, Ho AD (Jul 1992). "Genomic organization of the putative human homeobox proto-oncogene HOX-11 (TCL-3) and its endogenous expression in T cells". Oncogene. 7 (7): 1325–30. PMID   1352396.
• Kennedy MA, Gonzalez-Sarmiento R, Kees UR, Lampert F, Dear N, Boehm T, Rabbitts TH (Oct 1991). "HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24". Proceedings of the National Academy of Sciences of the United States of America. 88 (20): 8900–4. Bibcode:1991PNAS...88.8900K. doi: 10.1073/pnas.88.20.8900 . PMC   52618 . PMID   1681546.
• Lu M, Gong ZY, Shen WF, Ho AD (Oct 1991). "The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein". The EMBO Journal. 10 (10): 2905–10. doi:10.1002/j.1460-2075.1991.tb07840.x. PMC   453003 . PMID   1717256.
• Dear TN, Colledge WH, Carlton MB, Lavenir I, Larson T, Smith AJ, Warren AJ, Evans MJ, Sofroniew MV, Rabbitts TH (Sep 1995). "The Hox11 gene is essential for cell survival during spleen development". Development. 121 (9): 2909–15. doi:10.1242/dev.121.9.2909. PMID   7555717.
• Dear TN, Sanchez-Garcia I, Rabbitts TH (May 1993). "The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes". Proceedings of the National Academy of Sciences of the United States of America. 90 (10): 4431–5. Bibcode:1993PNAS...90.4431D. doi: 10.1073/pnas.90.10.4431 . PMC   46525 . PMID   8099440.
• Kawabe T, Muslin AJ, Korsmeyer SJ (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature. 385 (6615): 454–8. Bibcode:1997Natur.385..454K. doi:10.1038/385454a0. PMID   9009195. S2CID   608633.
• Brake RL, Kees UR, Watt PM (Oct 1998). "Multiple negative elements contribute to repression of the HOX11 proto-oncogene". Oncogene. 17 (14): 1787–95. doi: 10.1038/sj.onc.1202078 . PMID   9778044.
• Zhang N, Shen W, Hawley RG, Lu M (Apr 1999). "HOX11 interacts with CTF1 and mediates hematopoietic precursor cell immortalization". Oncogene. 18 (13): 2273–9. doi: 10.1038/sj.onc.1202545 . PMID   10327073.
• Watt PM, Ranford PR, Kees UR (Jun 1999). "Sequence of 10q24 locus surrounding the HOX11 oncogene reveals a new gene HUG1 expressed in a T-ALL cell line". Gene. 234 (1): 169–76. doi:10.1016/S0378-1119(99)00157-2. PMID   10393251.
• Brake RL, Kees UR, Watt PM (May 2002). "A complex containing PBX2 contributes to activation of the proto-oncogene HOX11". Biochemical and Biophysical Research Communications. 294 (1): 23–34. doi:10.1016/S0006-291X(02)00426-6. PMID   12054735.
• Bodenmiller DM, Baxter CS, Hansen DV, Potter SS (Apr 2002). "Phylogenetic analysis of Hoxa 11 sequences reveals absence of transposable elements, conservation of transcription factor binding sites, and suggests antisense coding function". DNA Sequence. 13 (2): 77–83. doi:10.1080/10425170290029981. PMID   12180349. S2CID   38713800.
• Cavé H, Suciu S, Preudhomme C, Poppe B, Robert A, Uyttebroeck A, Malet M, Boutard P, Benoit Y, Mauvieux L, Lutz P, Méchinaud F, Grardel N, Mazingue F, Dupont M, Margueritte G, Pages MP, Bertrand Y, Plouvier E, Brunie G, Bastard C, Plantaz D, Vande Velde I, Hagemeijer A, Speleman F, Lessard M, Otten J, Vilmer E, Dastugue N (Jan 2004). "Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951". Blood. 103 (2): 442–50. doi: 10.1182/blood-2003-05-1495 . PMID   14504110.
• Hoffmann K, Dixon DN, Greene WK, Ford J, Taplin R, Kees UR (Dec 2004). "A microarray model system identifies potential new target genes of the proto-oncogene HOX11". Genes, Chromosomes & Cancer. 41 (4): 309–20. doi:10.1002/gcc.20104. PMID   15384172. S2CID   19475690.
• Riz I, Hawley RG (Aug 2005). "G1/S transcriptional networks modulated by the HOX11/TLX1 oncogene of T-cell acute lymphoblastic leukemia". Oncogene. 24 (36): 5561–75. doi:10.1038/sj.onc.1208727. PMC   2408753 . PMID   15897879.
• Heidari M, Rice KL, Phillips JK, Kees UR, Greene WK (Feb 2006). "The nuclear oncoprotein TLX1/HOX11 associates with pericentromeric satellite 2 DNA in leukemic T-cells". Leukemia. 20 (2): 304–12. doi: 10.1038/sj.leu.2404071 . PMID   16357834.
• Chen E, Lim MS, Rosic-Kablar S, Liu J, Jolicoeur P, Dubé ID, Hough MR (Apr 2006). "Dysregulated expression of mitotic regulators is associated with B-cell lymphomagenesis in HOX11-transgenic mice". Oncogene. 25 (18): 2575–87. doi: 10.1038/sj.onc.1209285 . PMID   16407851.