KDM3B

KDM3B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4C8D
Identifiers
Aliases	KDM3B , 5qNCA, C5orf7, JMJD1B, NET22, lysine demethylase 3B, DIJOS
External IDs	OMIM: 609373; MGI: 1923356; HomoloGene: 41145; GeneCards: KDM3B; OMA:KDM3B - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q31.2 Start 138,352,685 bp [1] End 138,437,028 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 B1 Start 34,910,100 bp [2] End 34,971,713 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence glutes monocyte caput epididymis gastric mucosa mucosa of ileum gastrocnemius muscle tibialis anterior muscle saphenous vein Top expressed in tail of embryo neural layer of retina genital tubercle granulocyte tibiofemoral joint ventricular zone renal corpuscle right ventricle thymus corneal stroma More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity antioxidant activity dioxygenase activity metal ion binding histone demethylase activity transcription cis-regulatory region binding chromatin DNA binding histone H3-methyl-lysine-9 demethylase activity Cellular component chromatin nucleus nucleoplasm Biological process cellular oxidant detoxification response to cisplatin transcription, DNA-templated regulation of transcription, DNA-templated histone H3-K9 demethylation chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51780 277250 Ensembl ENSG00000120733 ENSMUSG00000038773 UniProt Q7LBC6 Q6ZPY7 RefSeq (mRNA) NM_016604 NM_001081256 NM_029518 RefSeq (protein) NP_057688 NP_001074725 Location (UCSC) Chr 5: 138.35 – 138.44 Mb Chr 18: 34.91 – 34.97 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Lysine-specific demethylase 3B is an enzyme that in humans is encoded by the KDM3B gene. ^{[5] [6]} KDM3B belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily.

References

1. GRCh38: Ensembl release 89: ENSG00000120733 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038773 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Katoh M, Katoh M (Jun 2004). "Identification and characterization of JMJD2 family genes in silico". International Journal of Oncology. 24 (6): 1623–8. doi:10.3892/ijo.25.3.759. PMID   15138608.
6. "Entrez Gene: JMJD1B jumonji domain containing 1B".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX   10.1.1.500.923 . doi:10.1093/dnares/9.3.99. PMID   12168954.
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC   16267 . PMID   10737800.
• Lai F, Godley LA, Fernald AA, Orelli BJ, Pamintuan L, Zhao N, Le Beau MM (Nov 2000). "cDNA cloning and genomic structure of three genes localized to human chromosome band 5q31 encoding potential nuclear proteins". Genomics. 70 (1): 123–30. doi:10.1006/geno.2000.6345. PMID   11087669.
• Lai F, Godley LA, Joslin J, Fernald AA, Liu J, Espinosa R, Zhao N, Pamintuan L, Till BG, Larson RA, Qian Z, Le Beau MM (Jan 2001). "Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q)". Genomics. 71 (2): 235–45. doi:10.1006/geno.2000.6414. PMID   11161817.
• Hu Z, Gomes I, Horrigan SK, Kravarusic J, Mar B, Arbieva Z, Chyna B, Fulton N, Edassery S, Raza A, Westbrook CA (Oct 2001). "A novel nuclear protein, 5qNCA (LOC51780) is a candidate for the myeloid leukemia tumor suppressor gene on chromosome 5 band q31". Oncogene. 20 (47): 6946–54. doi:10.1038/sj.onc.1204850. PMID   11687974. S2CID   2709519.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (Jan 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Yamane K, Toumazou C, Tsukada Y, Erdjument-Bromage H, Tempst P, Wong J, Zhang Y (May 2006). "JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor". Cell. 125 (3): 483–95. doi: 10.1016/j.cell.2006.03.027 . PMID   16603237. S2CID   6643329.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.

External links

• JMJD1B+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.