DLX2

Last updated
DLX2
Protein DLX2 PDB 2djn.png
Identifiers
Aliases DLX2 , TES-1, TES1, AW121999, Dlx-2, distal-less homeobox 2
External IDs OMIM: 126255 MGI: 94902 HomoloGene: 3244 GeneCards: DLX2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004405

NM_010054

RefSeq (protein)

NP_004396
NP_004396.1

NP_034184

Location (UCSC) Chr 2: 172.1 – 172.1 Mb Chr 2: 71.37 – 71.38 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein DLX-2 is a protein that in humans is encoded by the DLX2 gene. [5] [6]

Contents

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2. [6]

Interactions

DLX2 has been shown to interact with DLX5, [7] MSX1 [7] and Msh homeobox 2. [7]

Related Research Articles

<span class="mw-page-title-main">Homeobox</span> DNA pattern affecting anatomy development

A homeobox is a DNA sequence, around 180 base pairs long, that regulates large-scale anatomical features in the early stages of embryonic development. For instance, mutations in a homeobox may change large-scale anatomical features of the full-grown organism.

Genes in the DLX family encode homeodomain transcription factors related to the Drosophiladistal-less(Dll) gene. The family has been related to a number of developmental features such as jaws and limbs. The family seems to be well preserved across species. As DLX/Dll are involved in limb development in most of the major phyla, including vertebrates, it has been suggested that Dll was involved in appendage growth in an early bilaterial ancestor.

<span class="mw-page-title-main">PBX1</span> Protein found in humans

Pre-B-cell leukemia transcription factor 1 is a protein that in humans is encoded by the PBX1 gene.

<span class="mw-page-title-main">Homeobox protein MSX-1</span> Protein-coding gene in the species Homo sapiens

Homeobox protein MSX-1, is a protein that in humans is encoded by the MSX1 gene. MSX1 transcripts are not only found in thyrotrope-derived TSH cells, but also in the TtT97 thyrotropic tumor, which is a well differentiated hyperplastic tissue that produces both TSHß- and a-subunits and is responsive to thyroid hormone. MSX1 is also expressed in highly differentiated pituitary cells which until recently was thought to be expressed exclusively during embryogenesis. There is a highly conserved structural organization of the members of the MSX family of genes and their abundant expression at sites of inductive cell–cell interactions in the embryo suggest that they have a pivotal role during early development.

<span class="mw-page-title-main">Msh homeobox 2</span> Protein-coding gene in the species Homo sapiens

Homeobox protein MSX-2 is a protein that in humans is encoded by the MSX2 gene.

<span class="mw-page-title-main">LHX3</span> Protein-coding gene in the species Homo sapiens

LIM/homeobox protein Lhx3 is a protein that in humans is encoded by the LHX3 gene.

<span class="mw-page-title-main">PKNOX1</span> Protein-coding gene in the species Homo sapiens

PBX/Knotted 1 Homeobox 1 (PKNOX1) is a protein that in humans is encoded by the PKNOX1 gene.

<span class="mw-page-title-main">DLX5</span> Mammalian protein found in Homo sapiens

Homeobox protein DLX-5 is a protein that in humans is encoded by the distal-less homeobox 5 gene, or DLX5 gene. DLX5 is a member of DLX gene family.

<span class="mw-page-title-main">HOXB1</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-B1 is a protein that in humans is encoded by the HOXB1 gene.

<span class="mw-page-title-main">DLX3</span> Mammalian protein found in Homo sapiens

Homeobox protein DLX-3 is a protein that in humans is encoded by the DLX3 gene.

<span class="mw-page-title-main">DLX4</span> Mammalian protein found in Homo sapiens

Homeobox protein DLX-4 is a protein that in humans is encoded by the DLX4 gene.

<i>EN1</i> (gene) Protein-coding gene in the species Homo sapiens

Homeobox protein engrailed-1 is a protein that in humans is encoded by the EN1 gene.

<span class="mw-page-title-main">HOXC11</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C11 is a protein that in humans is encoded by the HOXC11 gene.

<span class="mw-page-title-main">MEIS2</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Meis2 is a protein that in humans is encoded by the MEIS2 gene.

<span class="mw-page-title-main">DLX1</span> Mammalian protein found in Homo sapiens

Homeobox protein DLX-1 is a protein that in humans is encoded by the DLX1 gene.

<span class="mw-page-title-main">DLX6</span> Mammalian protein found in Homo sapiens

Homeobox protein DLX-6 is a protein that in humans is encoded by the DLX6 gene.

<span class="mw-page-title-main">NKX2-3</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Nkx-2.3 is a protein that in humans is encoded by the NKX2-3 gene.

<span class="mw-page-title-main">LHX2</span> Protein-coding gene in the species Homo sapiens

LIM/homeobox protein Lhx2 is a protein that in humans is encoded by the LHX2 gene.

<span class="mw-page-title-main">VAX1</span> Protein-coding gene in the species Homo sapiens

Ventral anterior homeobox 1 is a protein that in humans is encoded by the VAX1 gene.

<span class="mw-page-title-main">NKX6-1</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000115844 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023391 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ozcelik T, Porteus MH, Rubenstein JL, Francke U (Sep 1992). "DLX2 (TES1), a homeobox gene of the Distal-less family, assigned to conserved regions on human and mouse chromosomes 2". Genomics. 13 (4): 1157–61. doi:10.1016/0888-7543(92)90031-M. PMID   1354641.
  6. 1 2 "Entrez Gene: DLX2 distal-less homeobox 2".
  7. 1 2 3 Zhang, H; Hu G; Wang H; Sciavolino P; Iler N; Shen M M; Abate-Shen C (May 1997). "Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism". Mol. Cell. Biol. UNITED STATES. 17 (5): 2920–32. doi:10.1128/mcb.17.5.2920. ISSN   0270-7306. PMC   232144 . PMID   9111364.

Further reading