Transcription factor SOX-11 is a protein that in humans is encoded by the SOX11 gene. [5] [6] [7]
Transcription factor SOX-11 is a protein that in humans is encoded by the SOX11 gene. [5] [6] [7]
This intronless gene encodes a member of the group C SOX (SRY-related HMG-box) transcription factor family involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis and adult neurogenesis. [7] [8] Tuj1 and Tead2 are suggested as direct target of Sox11. [9] [10] [11]
Lymphocyte staining for SOX11 immunohistochemistry indicates mantle cell lymphoma (cyclin D1 positive and negative) rather than other mature lymphoid neoplasms or normal lymphocytes. [12]
Mutations in SOX11 are associated with Coffin–Siris syndrome [13] and mantle cell lymphoma. [14]
Sex-determining region Y protein (SRY), or Testis-determining factor (TDF), is a DNA-binding protein encoded by the SRY gene that is responsible for the initiation of male sex determination in therian mammals. SRY is an intronless sex-determining gene on the Y chromosome. Mutations in this gene lead to a range of disorders of sex development with varying effects on an individual's phenotype and genotype.
SOX genes encode a family of transcription factors that bind to the minor groove in DNA, and belong to a super-family of genes characterized by a homologous sequence called the HMG-box. This HMG box is a DNA binding domain that is highly conserved throughout eukaryotic species. Homologues have been identified in insects, nematodes, amphibians, reptiles, birds and a range of mammals. However, HMG boxes can be very diverse in nature, with only a few amino acids being conserved between species.
The steroidogenic factor 1 (SF-1) protein is a transcription factor involved in sex determination by controlling activity of genes related to the reproductive glands or gonads and adrenal glands. This protein is encoded by the NR5A1 gene, a member of the nuclear receptor subfamily, located on the long arm of chromosome 9 at position 33.3. It was originally identified as a regulator of genes encoding cytochrome P450 steroid hydroxylases, however, further roles in endocrine function have since been discovered.
SRY -box 2, also known as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem cells. Sox2 has a critical role in maintenance of embryonic and neural stem cells.
Transcription factor SOX-9 is a protein that in humans is encoded by the SOX9 gene.
Transcription factor 12 is a protein that in humans is encoded by the TCF12 gene.
Transcription factor SOX-4 is a protein that in humans is encoded by the SOX4 gene.
Transcription factor Maf also known as proto-oncogene c-Maf or V-maf musculoaponeurotic fibrosarcoma oncogene homolog is a transcription factor that in humans is encoded by the MAF gene.
Transcription factor SOX-3 is a protein that in humans is encoded by the SOX3 gene. This gene encodes a member of the SOX family of transcription factors involved in the regulation of embryonic brain development and in determination of cell fate. The encoded protein acts as a transcriptional activator.
Transcription factor SOX-5 is a protein that in humans is encoded by the SOX5 gene.
Transcription factor SOX-13 is a protein that in humans is encoded by the SOX13 gene.
Transcription factor SOX-18 is a protein that in humans is encoded by the SOX18 gene.
B-cell lymphoma/leukemia 11B is a protein that in humans is encoded by the BCL11B gene.
Transcription factor SOX-8 is a protein that in humans is encoded by the SOX8 gene.
Protein SOX-15 is a protein that in humans is encoded by the SOX15 gene.
SOX12 is a protein that in humans is encoded by the SOX12 gene. Sox12 belongs to the SoxC group of Sox family of transcription factors, together with Sox4 and Sox11. Sox12-null knockout mice appear normal, unlike Sox4 or Sox11 knockout mice. This probably comes from functional redundancy with Sox4 and Sox11. Sox12 is a weaker activator than both Sox4 and Sox11 in mouse.
Transcription factor SOX-14 is a protein that in humans is encoded by the SOX14 gene.
Transcription factor SOX-21 is a protein that in humans is encoded by the SOX21 gene. It is a member of the Sox gene family of transcription factors.
Nuclear factor -like factor 3, also known as NFE2L3 or 'NRF3', is a transcription factor that in humans is encoded by the Nfe2l3 gene.
SRY-box 7 is a protein that in humans is encoded by the SOX7 gene.
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