MXD4

Last updated
MXD4
Identifiers
Aliases MXD4 , MAD4, MST149, MSTP149, bHLHc12, MAX dimerization protein 4
External IDs MGI: 104991 HomoloGene: 4712 GeneCards: MXD4
Orthologs
SpeciesHumanMouse
Entrez

10608

17122

Ensembl

ENSG00000123933

ENSMUSG00000037235

UniProt

Q14582

Q60948

RefSeq (mRNA)

NM_006454

NM_010753

RefSeq (protein)

NP_006445

n/a

Location (UCSC) Chr 4: 2.25 – 2.26 Mb Chr 5: 34.33 – 34.35 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Max-interacting transcriptional repressor MAD4 is a protein that in humans is encoded by the MXD4 gene. [5] [6]

Contents

Function

This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. [6]

Related Research Articles

Basic helix–loop–helix Protein structural motif

A basic helix–loop–helix (bHLH) is a protein structural motif that characterizes one of the largest families of dimerizing transcription factors. The word "basic" does not refer to complexity but to the chemistry of the motif because transcription factors in general contain basic amino acid residues in order to facilitate DNA binding.

Mothers against decapentaplegic homolog 3 Protein-coding gene in humans

Mothers against decapentaplegic homolog 3 also known as SMAD family member 3 or SMAD3 is a protein that in humans is encoded by the SMAD3 gene.

Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three related human genes: c-myc (MYC), l-myc (MYCL), and n-myc (MYCN). c-myc was the first gene to be discovered in this family, due to homology with the viral gene v-myc.

Myogenin Mammalian protein found in Homo sapiens

Myogenin, is a transcriptional activator encoded by the MYOG gene. Myogenin is a muscle-specific basic-helix-loop-helix (bHLH) transcription factor involved in the coordination of skeletal muscle development or myogenesis and repair. Myogenin is a member of the MyoD family of transcription factors, which also includes MyoD, Myf5, and MRF4.

N-Myc Protein-coding gene in the species Homo sapiens

N-myc proto-oncogene protein also known as N-Myc or basic helix-loop-helix protein 37 (bHLHe37), is a protein that in humans is encoded by the MYCN gene.

TCF3 Protein-coding gene in the species Homo sapiens

Transcription factor 3, also known as TCF3, is a protein that in humans is encoded by the TCF3 gene. TCF3 has been shown to directly enhance Hes1 expression.

SIN3A

Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the SIN3A gene.

ID1 Protein-coding gene in the species Homo sapiens

DNA-binding protein inhibitor ID-1 is a protein that in humans is encoded by the ID1 gene.

YY1 Transcriptional repressor protein

YY1 is a transcriptional repressor protein in humans that is encoded by the YY1 gene.

MAX (gene) Protein-coding gene in the species Homo sapiens

MAX is a gene that in humans encodes the MAX transcription factor.

MXI1

MAX-interacting protein 1 is a protein that in humans is encoded by the MXI1 gene.

DLX5 Mammalian protein found in Homo sapiens

Homeobox protein DLX-5 is a protein that in humans is encoded by the distal-less homeobox 5 gene, or DLX5 gene. DLX5 is a member of DLX gene family.

MXD1 Protein-coding gene in the species Homo sapiens

MAD protein is a protein that in humans is encoded by the MXD1 gene.

<i>MLX</i> (gene) Protein-coding gene in the species Homo sapiens

Max-like protein X is a protein that in humans is encoded by the MLX gene.

PUF60 Protein-coding gene in the species Homo sapiens

Poly(U)-binding-splicing factor PUF60 is a protein that in humans is encoded by the PUF60 gene.

MNT (gene) Protein-coding gene in the species Homo sapiens

MNT is a Max-binding protein that is encoded by the MNT gene

PFDN5

Prefoldin subunit 5 is a protein that in humans is encoded by the PFDN5 gene.

LMX1A Protein-coding gene in the species Homo sapiens

LIM homeobox transcription factor 1, alpha, also known as LMX1A, is a protein which in humans is encoded by the LMX1A gene.

Carbohydrate-responsive element-binding protein

Carbohydrate-responsive element-binding protein (ChREBP) also known as MLX-interacting protein-like (MLXIPL) is a protein that in humans is encoded by the MLXIPL gene. The protein name derives from the protein's interaction with carbohydrate response element sequences of DNA.

MXD3 Protein-coding gene in the species Homo sapiens

MAX dimerization protein 3 is a protein that in humans is encoded by the MXD3 gene located on Chromosome 5.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000123933 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037235 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Hurlin PJ, Quéva C, Koskinen PJ, Steingrímsson E, Ayer DE, Copeland NG, Jenkins NA, Eisenman RN (November 1995). "Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation". The EMBO Journal. 14 (22): 5646–59. doi:10.1002/j.1460-2075.1995.tb00252.x. PMC   394680 . PMID   8521822.
  6. 1 2 "Entrez Gene: MXD4 MAX dimerization protein 4".

Further reading

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