TFCP2

TFCP2
Identifiers
Aliases	TFCP2 , LBP1C, LSF, LSF1D, SEF, TFCP2C, transcription factor CP2
External IDs	OMIM: 189889; MGI: 98509; HomoloGene: 4134; GeneCards: TFCP2; OMA:TFCP2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q13.12-q13.13 Start 51,093,656 bp [1] End 51,173,135 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15 F1|15 56.33 cM Start 100,395,893 bp [2] End 100,449,889 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of paranasal sinus superficial temporal artery ventricular zone monocyte ganglionic eminence granulocyte rectum gastrocnemius muscle gonad islet of Langerhans Top expressed in neural layer of retina pineal gland genital tubercle tail of embryo ventricular zone perirhinal cortex renal corpuscle entorhinal cortex right kidney neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein C-terminus binding protein binding sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific cis-regulatory region sequence-specific DNA binding transcription factor binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component nucleoplasm cytosol nucleus protein-containing complex Biological process regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II mRNA transcription by RNA polymerase II regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7024 21422 Ensembl ENSG00000135457 ENSMUSG00000009733 UniProt Q12800 Q9ERA0 RefSeq (mRNA) NM_005653 NM_001173452 NM_001173453 NM_001289603 NM_033476 NM_001355497 RefSeq (protein) NP_001166923 NP_001166924 NP_005644 NP_001276532 NP_258437 NP_001342426 Location (UCSC) Chr 12: 51.09 – 51.17 Mb Chr 15: 100.4 – 100.45 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Alpha-globin transcription factor CP2 is a protein that in humans is encoded by the TFCP2 gene. ^{[5] [6]}

TFCP2 is also called Late SV40 factor (LSF) and it is induced by well-known oncogene AEG-1. ^[7] LSF also acts as an oncogene in hepatocellular carcinoma. ^[8] LSF enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9). ^[9]

Along with its main oncogene function in hepatocellular carcinoma (HCC), it plays multifaceted role in chemoresistance, epithelial-mesenchymal transition (EMT), allergic response, inflammation and Alzheimer's disease. ^{[8] [10]} The small molecule FQI1 (factor quinolinone inhibitor 1) prevents LSF from binding with HCC DNA, which results in HCC cell death. ^{[8] [10] [11]}

Interactions

TFCP2 has been shown to interact with APBB1 ^[12] and RNF2. ^[13]

References

1. GRCh38: Ensembl release 89: ENSG00000135457 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000009733 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Swendeman SL, Spielholz C, Jenkins NA, Gilbert DJ, Copeland NG, Sheffery M (Apr 1994). "Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2". The Journal of Biological Chemistry. 269 (15): 11663–71. doi: 10.1016/S0021-9258(19)78176-9 . PMID   8157699.
6. "Entrez Gene: TFCP2 transcription factor CP2".
7. Yoo BK, Gredler R, Vozhilla N, Su ZZ, Chen D, Forcier T, Shah K, Saxena U, Hansen U, Fisher PB, Sarkar D (Aug 2009). "Identification of genes conferring resistance to 5-fluorouracil". Proceedings of the National Academy of Sciences of the United States of America. 106 (31): 12938–43. Bibcode:2009PNAS..10612938Y. doi: 10.1073/pnas.0901451106 . PMC   2722317 . PMID   19622726.
8. Yoo BK, Emdad L, Gredler R, Fuller C, Dumur CI, Jones KH, Jackson-Cook C, Su ZZ, Chen D, Saxena UH, Hansen U, Fisher PB, Sarkar D (May 2010). "Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 107 (18): 8357–62. Bibcode:2010PNAS..107.8357Y. doi: 10.1073/pnas.1000374107 . PMC   2889542 . PMID   20404171.
9. Santhekadur PK, Gredler R, Chen D, Siddiq A, Shen XN, Das SK, Emdad L, Fisher PB, Sarkar D (Jan 2012). "Late SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP-9)". The Journal of Biological Chemistry. 287 (5): 3425–32. doi: 10.1074/jbc.M111.298976 . PMC   3270996 . PMID   22167195.
10. Santhekadur PK, Rajasekaran D, Siddiq A, Gredler R, Chen D, Schaus SC, Hansen U, Fisher PB, Sarkar D (2012). "The transcription factor LSF: a novel oncogene for hepatocellular carcinoma" (PDF). Am J Cancer Res. 2 (3): 269–285. PMC   3365805 . PMID   22679558.
11. Grant TJ, Bishop JA, Christadore LM, Barot G, Chin HG, Woodson S, Kavouris J, Siddiq A, Gredler R, Shen XN, Sherman J, Meehan T, Fitzgerald K, Pradhan S, Briggs LA, Andrews WH, Sarkar D, Schaus SE, Hansen U (Mar 2012). "Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 109 (12): 4503–8. Bibcode:2012PNAS..109.4503G. doi: 10.1073/pnas.1121601109 . PMC   3311344 . PMID   22396589.
12. Zambrano N, Minopoli G, de Candia P, Russo T (Aug 1998). "The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1". The Journal of Biological Chemistry. 273 (32): 20128–33. doi: 10.1074/jbc.273.32.20128 . PMID   9685356.
13. Tuckfield A, Clouston DR, Wilanowski TM, Zhao LL, Cunningham JM, Jane SM (Mar 2002). "Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors". Molecular and Cellular Biology. 22 (6): 1936–46. doi:10.1128/MCB.22.6.1936-1946.2002. PMC   135618 . PMID   11865070.

Further reading

• Lim LC, Swendeman SL, Sheffery M (Feb 1992). "Molecular cloning of the alpha-globin transcription factor CP2". Molecular and Cellular Biology. 12 (2): 828–35. doi:10.1128/mcb.12.2.828. PMC   364316 . PMID   1732747.
• Jane SM, Nienhuis AW, Cunningham JM (Jan 1995). "Hemoglobin switching in man and chicken is mediated by a heteromeric complex between the ubiquitous transcription factor CP2 and a developmentally specific protein". The EMBO Journal. 14 (1): 97–105. doi:10.1002/j.1460-2075.1995.tb06979.x. PMC   398056 . PMID   7828600.
• Shirra MK, Zhu Q, Huang HC, Pallas D, Hansen U (Aug 1994). "One exon of the human LSF gene includes conserved regions involved in novel DNA-binding and dimerization motifs". Molecular and Cellular Biology. 14 (8): 5076–87. doi:10.1128/mcb.14.8.5076. PMC   359026 . PMID   8035790.
• Yoon JB, Li G, Roeder RG (Mar 1994). "Characterization of a family of related cellular transcription factors which can modulate human immunodeficiency virus type 1 transcription in vitro". Molecular and Cellular Biology. 14 (3): 1776–85. doi:10.1128/mcb.14.3.1776. PMC   358535 . PMID   8114710.
• Margolis DM, Somasundaran M, Green MR (Feb 1994). "Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production". Journal of Virology. 68 (2): 905–10. doi:10.1128/JVI.68.2.905-910.1994. PMC   236527 . PMID   8289393.
• Cunningham JM, Vanin EF, Tran N, Valentine M, Jane SM (Nov 1995). "The human transcription factor CP2 (TFCP2), a component of the human gamma-globin stage selector protein, maps to chromosome region 12q13 and is within 250 kb of the NF-E2 gene". Genomics. 30 (2): 398–9. PMID   8586452.
• Romerio F, Gabriel MN, Margolis DM (Dec 1997). "Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF". Journal of Virology. 71 (12): 9375–82. doi:10.1128/JVI.71.12.9375-9382.1997. PMC   230241 . PMID   9371597.
• Zambrano N, Minopoli G, de Candia P, Russo T (Aug 1998). "The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1". The Journal of Biological Chemistry. 273 (32): 20128–33. doi: 10.1074/jbc.273.32.20128 . PMID   9685356.
• Bing Z, Reddy SA, Ren Y, Qin J, Liao WS (Aug 1999). "Purification and characterization of the serum amyloid A3 enhancer factor". The Journal of Biological Chemistry. 274 (35): 24649–56. doi: 10.1074/jbc.274.35.24649 . PMID   10455131.
• Coull JJ, Romerio F, Sun JM, Volker JL, Galvin KM, Davie JR, Shi Y, Hansen U, Margolis DM (Aug 2000). "The human factors YY1 and LSF repress the human immunodeficiency virus type 1 long terminal repeat via recruitment of histone deacetylase 1". Journal of Virology. 74 (15): 6790–9. doi:10.1128/JVI.74.15.6790-6799.2000. PMC   112196 . PMID   10888618.
• Zhou W, Clouston DR, Wang X, Cerruti L, Cunningham JM, Jane SM (Oct 2000). "Induction of human fetal globin gene expression by a novel erythroid factor, NF-E4". Molecular and Cellular Biology. 20 (20): 7662–72. doi:10.1128/MCB.20.20.7662-7672.2000. PMC   86334 . PMID   11003662.
• Rodda S, Sharma S, Scherer M, Chapman G, Rathjen P (Feb 2001). "CRTR-1, a developmentally regulated transcriptional repressor related to the CP2 family of transcription factors". The Journal of Biological Chemistry. 276 (5): 3324–32. doi: 10.1074/jbc.M008167200 . PMID   11073954.
• Zheng JB, Zhou YH, Maity T, Liao WS, Saunders GF (Oct 2001). "Activation of the human PAX6 gene through the exon 1 enhancer by transcription factors SEF and Sp1". Nucleic Acids Research. 29 (19): 4070–8. doi:10.1093/nar/29.2.e6. PMC   60230 . PMID   11574690.
• Tuckfield A, Clouston DR, Wilanowski TM, Zhao LL, Cunningham JM, Jane SM (Mar 2002). "Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors". Molecular and Cellular Biology. 22 (6): 1936–46. doi:10.1128/MCB.22.6.1936-1946.2002. PMC   135618 . PMID   11865070.
• He G, Margolis DM (May 2002). "Counterregulation of chromatin deacetylation and histone deacetylase occupancy at the integrated promoter of human immunodeficiency virus type 1 (HIV-1) by the HIV-1 repressor YY1 and HIV-1 activator Tat". Molecular and Cellular Biology. 22 (9): 2965–73. doi:10.1128/MCB.22.9.2965-2973.2002. PMC   133763 . PMID   11940654.
• Peters LM, Anderson DW, Griffith AJ, Grundfast KM, San Agustin TB, Madeo AC, Friedman TB, Morell RJ (Nov 2002). "Mutation of a transcription factor, TFCP2L3, causes progressive autosomal dominant hearing loss, DFNA28". Human Molecular Genetics. 11 (23): 2877–85. doi: 10.1093/hmg/11.23.2877 . PMID   12393799.
• Luedecking-Zimmer E, DeKosky ST, Nebes R, Kamboh MI (Feb 2003). "Association of the 3' UTR transcription factor LBP-1c/CP2/LSF polymorphism with late-onset Alzheimer's disease". American Journal of Medical Genetics Part B. 117B (1): 114–7. doi:10.1002/ajmg.b.10026. PMID   12555245. S2CID   24087609.
• Chae JH, Kim CG (Feb 2003). "CP2 binding to the promoter is essential for the enhanced transcription of globin genes in erythroid cells". Molecules and Cells. 15 (1): 40–7. doi: 10.1016/S1016-8478(23)25235-8 . PMID   12661759.