ZNF300

ZNF300
Identifiers
Aliases	ZNF300 , zinc finger protein 300
External IDs	OMIM: 612429 HomoloGene: 56531 GeneCards: ZNF300
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q33.1 Start 150,894,392 bp [1] End 150,904,983 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence Achilles tendon metanephros left lobe of thyroid gland body of pancreas stromal cell of endometrium right lobe of thyroid gland pancreatic epithelial cell tibial nerve smooth muscle tissue n/a More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein binding metal ion binding nucleic acid binding DNA-binding transcription activator activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component intracellular anatomical structure nucleus nucleolus Biological process regulation of transcription, DNA-templated transcription, DNA-templated transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 91975 n/a Ensembl ENSG00000145908 n/a UniProt Q96RE9 n/a RefSeq (mRNA) NM_001172831 NM_001172832 NM_052860 n/a RefSeq (protein) NP_001166302 NP_001166303 NP_443092 n/a Location (UCSC) Chr 5: 150.89 – 150.9 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Zinc finger protein 300 is a protein that in humans is encoded by the ZNF300 gene. ^{[3] [4]} The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and a likely transcription factor.

It is antisense to the human gene, C16orf71, indicating possibility of regulated alternative expression. ^[5]

Clinical relevance

It is associated with Crohn's disease. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000145908 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Gou D, Wang J, Gao L, Sun Y, Peng X, Huang J, Li W (January 2004). "Identification and functional analysis of a novel human KRAB/C2H2 zinc finger gene ZNF300". Biochim. Biophys. Acta. 1676 (2): 203–9. doi:10.1016/j.bbaexp.2003.11.011. PMID   14746915.
4. "Entrez Gene: zinc finger protein 300".
5. "AceView: Gene:C16orf71, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". www.ncbi.nlm.nih.gov. Retrieved 2017-05-20.{{cite web}}: |first= missing |last= (help)
6. Prescott NJ, Dominy KM, Kubo M, Lewis CM, Fisher SA, Redon R, Huang N, Stranger BE, Blaszczyk K, Hudspith B, Parkes G, Hosono N, Yamazaki K, Onnie CM, Forbes A, Dermitzakis ET, Nakamura Y, Mansfield JC, Sanderson J, Hurles ME, Roberts RG, Mathew CG (May 2010). "Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease" (PDF). Hum. Mol. Genet. 19 (9): 1828–39. doi:10.1093/hmg/ddq041. PMC   2850616 . PMID   20106866.

Further reading

• Feng T, Zhu X (2010). "Genome-wide searching of rare genetic variants in WTCCC data". Hum. Genet. 128 (3): 269–80. doi:10.1007/s00439-010-0849-9. PMC   2922446 . PMID   20549515.
• Qiu H, Xue L, Gao L, et al. (2008). "Identification of the DNA binding element of the human ZNF300 protein". Cell. Mol. Biol. Lett. 13 (3): 391–403. doi:10.2478/s11658-008-0005-x. PMC   6275660 . PMID   18350257.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Xu JH, Wang T, Wang XG, et al. (2010). "PU.1 can regulate the ZNF300 promoter in APL-derived promyelocytes HL-60". Leuk. Res. 34 (12): 1636–46. doi:10.1016/j.leukres.2010.04.009. PMID   20471086.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Xue L, Qiu H, Ma J, et al. (2010). "ZNF300, a recently identified human transcription factor, activates the human IL-2Rβ promoter through the overlapping ZNF300/EGR1 binding site". Cell. Mol. Biol. Lett. 15 (4): 530–40. doi:10.2478/s11658-010-0025-1. PMC   6275642 . PMID   20585888.
• Oh JH, Yang JO, Hahn Y, et al. (2005). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID   16341674. S2CID   69278.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Cao Y, Li JX, Ji CN, et al. (2007). "Molecular cloning and characterization of a novel splice variant of human ZNF300 gene, which expressed highly in testis". DNA Seq. 18 (4): 312–5. doi:10.1080/10425170701243393. PMID   17541838. S2CID   12932222.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Wellcome Trust Case Control Consortium; Clayton, David G.; Cardon, Lon R.; Craddock, Nick; Deloukas, Panos; Duncanson, Audrey; Kwiatkowski, Dominic P.; McCarthy, Mark I.; Ouwehand, Willem H.; Samani, Nilesh J.; Todd, John A.; Donnelly, Peter; Barrett, Jeffrey C.; Burton, Paul R.; Davison, Dan; Donnelly, Peter; Easton, Doug; Evans, David; Leung, Hin-Tak; Marchini, Jonathan L.; Morris, Andrew P.; Spencer, Chris C. A.; Tobin, Martin D.; Cardon, Lon R.; Clayton, David G.; Attwood, Antony P.; Boorman, James P.; Cant, Barbara; Everson, Ursula; et al. (2007). "Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls". Nature. 447 (7145): 661–78. Bibcode:2007Natur.447..661B. doi:10.1038/nature05911. PMC   2719288 . PMID   17554300.