ZNF300

ZNF300
Identifiers
Aliases	ZNF300 , zinc finger protein 300
External IDs	OMIM: 612429; HomoloGene: 56531; GeneCards: ZNF300; OMA:ZNF300 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q33.1 Start 150,894,392 bp [1] End 150,904,983 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone Achilles tendon gonad left ovary right ovary testicle metanephros left lobe of thyroid gland body of pancreas n/a More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein binding metal ion binding nucleic acid binding DNA-binding transcription activator activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component intracellular anatomical structure nucleus nucleolus Biological process regulation of transcription, DNA-templated transcription, DNA-templated transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 91975 n/a Ensembl ENSG00000145908 n/a UniProt Q96RE9 n/a RefSeq (mRNA) NM_001172831 NM_001172832 NM_052860 n/a RefSeq (protein) NP_001166302 NP_001166303 NP_443092 n/a Location (UCSC) Chr 5: 150.89 – 150.9 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Zinc finger protein 300 is a protein that in humans is encoded by the ZNF300 gene. ^{[3] [4]} The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and a likely transcription factor.

It is antisense to the human gene, C16orf71, indicating possibility of regulated alternative expression. ^[5]

Clinical relevance

It is associated with Crohn's disease. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000145908 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Gou D, Wang J, Gao L, Sun Y, Peng X, Huang J, et al. (January 2004). "Identification and functional analysis of a novel human KRAB/C2H2 zinc finger gene ZNF300". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1676 (2): 203–209. doi:10.1016/j.bbaexp.2003.11.011. PMID   14746915.
4. "Entrez Gene: zinc finger protein 300".
5. Danielle Thierry-Mieg, Jean Thierry-Mieg. "AceView: Gene:C16orf71, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". www.ncbi.nlm.nih.gov. Retrieved 2017-05-20.
6. Prescott NJ, Dominy KM, Kubo M, Lewis CM, Fisher SA, Redon R, et al. (May 2010). "Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease". Human Molecular Genetics. 19 (9): 1828–1839. doi:10.1093/hmg/ddq041. PMC   2850616 . PMID   20106866.

Further reading

• Feng T, Zhu X (September 2010). "Genome-wide searching of rare genetic variants in WTCCC data". Human Genetics. 128 (3): 269–280. doi:10.1007/s00439-010-0849-9. PMC   2922446 . PMID   20549515.
• Qiu H, Xue L, Gao L, Shao H, Wang D, Guo M, et al. (2008). "Identification of the DNA binding element of the human ZNF300 protein". Cellular & Molecular Biology Letters. 13 (3): 391–403. doi:10.2478/s11658-008-0005-x. PMC   6275660 . PMID   18350257.
• Xu JH, Wang T, Wang XG, Wu XP, Zhao ZZ, Zhu CG, et al. (December 2010). "PU.1 can regulate the ZNF300 promoter in APL-derived promyelocytes HL-60". Leukemia Research. 34 (12): 1636–1646. doi:10.1016/j.leukres.2010.04.009. PMID   20471086.
• Xue L, Qiu H, Ma J, Guo M, Li W (December 2010). "ZNF300, a recently identified human transcription factor, activates the human IL-2Rβ promoter through the overlapping ZNF300/EGR1 binding site". Cellular & Molecular Biology Letters. 15 (4): 530–540. doi:10.2478/s11658-010-0025-1. PMC   6275642 . PMID   20585888.
• Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, et al. (December 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome. 16 (12): 942–954. doi:10.1007/s00335-005-0075-2. PMID   16341674. S2CID   69278.
• Cao Y, Li JX, Ji CN, Xu XW, Wu M (August 2007). "Molecular cloning and characterization of a novel splice variant of human ZNF300 gene, which expressed highly in testis". DNA Sequence. 18 (4): 312–315. doi:10.1080/10425170701243393. PMID   17541838. S2CID   12932222.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, et al. (Wellcome Trust Case Control Consortium) (June 2007). "Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls". Nature. 447 (7145): 661–678. Bibcode:2007Natur.447..661B. doi:10.1038/nature05911. PMC   2719288 . PMID   17554300.