Transcription factor 15

TCF15
Identifiers
Aliases	TCF15 , EC2, PARAXIS, bHLHa40, transcription factor 15 (basic helix-loop-helix), transcription factor 15
External IDs	OMIM: 601010; MGI: 104664; HomoloGene: 37943; GeneCards: TCF15; OMA:TCF15 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20p13 Start 604,257 bp [1] End 610,309 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2 G3|2 74.83 cM Start 151,985,481 bp [2] End 151,991,017 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle apex of heart vena cava glutes Skeletal muscle tissue of biceps brachii dorsal motor nucleus of vagus nerve Skeletal muscle tissue of rectus abdominis body of tongue left ventricle gonad Top expressed in somite digastric muscle sclerotome sternocleidomastoid muscle masseter muscle tibialis anterior muscle intercostal muscle interventricular septum myocardium of ventricle triceps brachii muscle More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein dimerization activity DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus RNA polymerase II transcription regulator complex Biological process somitogenesis respiratory system process regulation of transcription, DNA-templated muscle organ morphogenesis eating behavior neuromuscular process controlling posture regulation of transcription by RNA polymerase II skeletal system morphogenesis muscle organ development ear development transcription, DNA-templated multicellular organism development establishment of epithelial cell apical/basal polarity regulation of extracellular matrix organization post-anal tail morphogenesis regulation of gene expression mesoderm development anterior/posterior pattern specification skin development paraxial mesoderm development mesenchymal to epithelial transition transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6939 21407 Ensembl ENSG00000125878 ENSMUSG00000068079 UniProt Q12870 Q60756 RefSeq (mRNA) NM_004609 NM_009328 RefSeq (protein) NP_004600 NP_033354 Location (UCSC) Chr 20: 0.6 – 0.61 Mb Chr 2: 151.99 – 151.99 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transcription factor 15 (TCF-15) also known as Paraxis, is a protein that in humans is encoded by the TCF15 gene. ^[5]

Function

Transcription factor 15 is found in the nucleus and is involved in the early transcriptional regulation of patterning of the mesoderm, and has a key role in somitogenesis. ^[6] The encoded basic helix-loop-helix protein requires dimerization with another basic helix-loop-helix protein for efficient DNA binding. [provided by RefSeq, Jul 2008].

References

1. GRCh38: Ensembl release 89: ENSG00000125878 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000068079 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Transcription factor 15" . Retrieved 2017-11-09.
6. "TCF15". UniProt. Retrieved 29 June 2025.

Further reading

• Guo P, Zhao KW, Dong XY, Sun X, Dong JT (2009). "Acetylation of KLF5 alters the assembly of p15 transcription factors in transforming growth factor-beta-mediated induction in epithelial cells". J. Biol. Chem. 284 (27): 18184–93. doi: 10.1074/jbc.M109.007096 . PMC   2709394 . PMID   19419955.
• Coppiello G, Collantes M, Sirerol-Piquer MS, Vandenwijngaert S, Schoors S, Swinnen M, Vandersmissen I, Herijgers P, Topal B, van Loon J, Goffin J, Prósper F, Carmeliet P, García-Verdugo JM, Janssens S, Peñuelas I, Aranguren XL, Luttun A (2015). "Meox2/Tcf15 heterodimers program the heart capillary endothelium for cardiac fatty acid uptake". Circulation. 131 (9): 815–26. doi: 10.1161/CIRCULATIONAHA.114.013721 . hdl: 10550/105619 . PMID   25561514.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.