Neurogenin-2

NEUROG2
Identifiers
Aliases	NEUROG2 , Atoh4, Math4A, NGN2, bHLHa8, ngn-2, neurogenin 2
External IDs	OMIM: 606624; MGI: 109619; HomoloGene: 7633; GeneCards: NEUROG2; OMA:NEUROG2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q25 Start 112,513,516 bp [1] End 112,516,180 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 G2 Start 127,426,784 bp [2] End 127,429,280 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone gonad right hemisphere of cerebellum putamen Amygdala caudate nucleus hippocampus proper prefrontal cortex anterior cingulate cortex Top expressed in ventricular zone rhombic lip fossa urethra ganglion of neuraxis ganglionic eminence pretectal area neural crest condyle zona limitans intrathalamica More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding E-box binding protein dimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process multicellular organism development nervous system development regulation of transcription, DNA-templated positive regulation of DNA-binding transcription factor activity neuron differentiation cell differentiation transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 63973 11924 Ensembl ENSG00000178403 ENSMUSG00000027967 UniProt Q9H2A3 P70447 RefSeq (mRNA) NM_024019 NM_009718 RefSeq (protein) NP_076924 NP_033848 Location (UCSC) Chr 4: 112.51 – 112.52 Mb Chr 3: 127.43 – 127.43 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neurogenin-2 is a protein that in humans is encoded by the NEUROG2 gene. ^[5]

Neurogenin-2 is a member of the neurogenin subfamily of basic helix-loop-helix (bHLH) transcription factor genes that play an important role in neurogenesis. ^[6]

It has been found to reprogram astrocytes to glutamatergic neurons when expressed. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000178403 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027967 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: neurogenin 2".
6. Heng JI, Nguyen L, Castro DS, Zimmer C, Wildner H, Armant O, et al. (September 2008). "Neurogenin 2 controls cortical neuron migration through regulation of Rnd2". Nature. 455 (7209): 114–118. Bibcode:2008Natur.455..114H. doi:10.1038/nature07198. PMID   18690213. S2CID   2813030.
7. Liu F, Zhang Y, Chen F, Yuan J, Li S, Han S, et al. (March 2021). "Neurog2 directly converts astrocytes into functional neurons in midbrain and spinal cord". Cell Death & Disease. 12 (3): 225. doi:10.1038/s41419-021-03498-x. PMC   7921562 . PMID   33649354.

Further reading

• Gradwohl G, Fode C, Guillemot F (November 1996). "Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors". Developmental Biology. 180 (1): 227–241. doi: 10.1006/dbio.1996.0297 . PMID   8948587.
• Simmons AD, Horton S, Abney AL, Johnson JE (January 2001). "Neurogenin2 expression in ventral and dorsal spinal neural tube progenitor cells is regulated by distinct enhancers". Developmental Biology. 229 (2): 327–339. doi: 10.1006/dbio.2000.9984 . PMID   11203697.
• Kumar M, Bagchi B, Gupta SK, Meena AS, Gressens P, Mani S (August 2007). "Neurospheres derived from human embryoid bodies treated with retinoic Acid show an increase in nestin and ngn2 expression that correlates with the proportion of tyrosine hydroxylase-positive cells". Stem Cells and Development. 16 (4): 667–681. doi:10.1089/scd.2006.0115. PMID   17784840.
• Deng S, Deng H, Le W, Xu H, Yang H, Deng X, et al. (January 2010). "Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease". Neuroscience Letters. 468 (3): 195–197. doi:10.1016/j.neulet.2009.10.078. PMID   19879328. S2CID   27698762.
• Park CH, Kang JS, Yoon EH, Shim JW, Suh-Kim H, Lee SH (March 2008). "Proneural bHLH neurogenin 2 differentially regulates Nurr1-induced dopamine neuron differentiation in rat and mouse neural precursor cells in vitro". FEBS Letters. 582 (5): 537–542. Bibcode:2008FEBSL.582..537P. doi:10.1016/j.febslet.2008.01.018. PMID   18242186. S2CID   33390799.
• Fode C, Gradwohl G, Morin X, Dierich A, LeMeur M, Goridis C, et al. (March 1998). "The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons". Neuron. 20 (3): 483–494. doi: 10.1016/S0896-6273(00)80989-7 . PMID   9539123. S2CID   16790307.