MLLT1

MLLT1
Identifiers
Aliases	MLLT1 , ENL, LTG19, YEATS1, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1, super elongation complex subunit, MLLT1 super elongation complex subunit
External IDs	OMIM: 159556; MGI: 1927238; HomoloGene: 4339; GeneCards: MLLT1; OMA:MLLT1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.3 Start 6,210,381 bp [1] End 6,279,975 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 D Start 57,199,611 bp [2] End 57,242,415 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cardiac muscle tissue of right atrium placenta right uterine tube right hemisphere of cerebellum myocardium of left ventricle tibialis anterior muscle nucleus accumbens right frontal lobe ventricular zone decidua Top expressed in ventricular zone dentate gyrus of hippocampal formation granule cell genital tubercle lip superior frontal gyrus primary visual cortex neural tube tail of embryo perirhinal cortex entorhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component transcription elongation factor complex nucleus fibrillar center nucleoplasm cytosol Biological process regulation of transcription, DNA-templated transcription by RNA polymerase II negative regulation of protein kinase activity transcription, DNA-templated transcription elongation from RNA polymerase II promoter regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4298 64144 Ensembl ENSG00000130382 ENSMUSG00000024212 UniProt Q03111 Q9ERL0 RefSeq (mRNA) NM_005934 NM_022328 RefSeq (protein) NP_005925 NP_071723 Location (UCSC) Chr 19: 6.21 – 6.28 Mb Chr 17: 57.2 – 57.24 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein ENL is a protein that in humans is encoded by the MLLT1 gene. ^[5]

Interactions

MLLT1 has been shown to interact with CBX8. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000130382 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024212 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1".
6. García-Cuéllar MP, Zilles O, Schreiner SA, Birke M, Winkler TH, Slany RK (January 2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. 20 (4): 411–9. doi: 10.1038/sj.onc.1204108 . PMID   11313972.

Further reading

• Tkachuk DC, Kohler S, Cleary ML (November 1992). "Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias". Cell. 71 (4): 691–700. doi:10.1016/0092-8674(92)90602-9. PMID   1423624. S2CID   11801536.
• Thirman MJ, Levitan DA, Kobayashi H, Simon MC, Rowley JD (December 1994). "Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia". Proceedings of the National Academy of Sciences of the United States of America. 91 (25): 12110–4. Bibcode:1994PNAS...9112110T. doi: 10.1073/pnas.91.25.12110 . PMC   45386 . PMID   7991593.
• Rubnitz JE, Morrissey J, Savage PA, Cleary ML (September 1994). "ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells". Blood. 84 (6): 1747–52. doi: 10.1182/blood.V84.6.1747.1747 . PMID   8080983.
• Yamamoto K, Seto M, Komatsu H, Iida S, Akao Y, Kojima S, Kodera Y, Nakazawa S, Ariyoshi Y, Takahashi T (October 1993). "Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia". Oncogene. 8 (10): 2617–25. PMID   8378076.
• Lavau C, Luo RT, Du C, Thirman MJ (September 2000). "Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice". Proceedings of the National Academy of Sciences of the United States of America. 97 (20): 10984–9. Bibcode:2000PNAS...9710984L. doi: 10.1073/pnas.190167297 . PMC   27135 . PMID   10995463.
• García-Cuéllar MP, Zilles O, Schreiner SA, Birke M, Winkler TH, Slany RK (January 2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. 20 (4): 411–9. doi: 10.1038/sj.onc.1204108 . PMID   11313972.
• Nie Z, Yan Z, Chen EH, Sechi S, Ling C, Zhou S, Xue Y, Yang D, Murray D, Kanakubo E, Cleary ML, Wang W (April 2003). "Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner". Molecular and Cellular Biology. 23 (8): 2942–52. doi:10.1128/MCB.23.8.2942-2952.2003. PMC   152562 . PMID   12665591.
• Gué M, Sun JS, Boudier T (January 2006). "Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited". BMC Cancer. 6: 20. doi: 10.1186/1471-2407-6-20 . PMC   1388228 . PMID   16433901.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Meyer C, Burmeister T, Strehl S, Schneider B, Hubert D, Zach O, Haas O, Klingebiel T, Dingermann T, Marschalek R (March 2007). "Spliced MLL fusions: a novel mechanism to generate functional chimeric MLL-MLLT1 transcripts in t(11;19)(q23;p13.3) leukemia". Leukemia. 21 (3): 588–90. doi:10.1038/sj.leu.2404542. PMID   17252016. S2CID   34843802.

External links

• MLLT1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.