GTF2H4

GTF2H4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5IY9, 5IVW, 5IY7, 5IY8, 5IY6
Identifiers
Aliases	GTF2H4 , general transcription factor IIH, polypeptide 4, 52kDa, P52, TFB2, TFIIH, general transcription factor IIH subunit 4
External IDs	OMIM: 601760 MGI: 1338799 HomoloGene: 7090 GeneCards: GTF2H4
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p21.33 Start 30,908,207 bp [1] End 30,914,106 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 B1 Start 35,978,622 bp [2] End 35,984,631 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver pituitary gland anterior pituitary left lobe of thyroid gland right lobe of thyroid gland right coronary artery tibial nerve smooth muscle tissue left coronary artery fundus Top expressed in thymus otic placode spermatocyte saccule abdominal wall maxillary prominence facial motor nucleus primitive streak yolk sac somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase activity ATP-dependent activity, acting on DNA DNA-binding transcription factor activity DNA helicase activity protein binding RNA polymerase II CTD heptapeptide repeat kinase activity double-stranded DNA binding ATPase activator activity RNA polymerase II general transcription initiation factor activity Cellular component nucleoplasm transcription factor TFIIH holo complex core TFIIH complex portion of holo TFIIH complex transcription factor TFIIH core complex nucleus transcription factor TFIID complex nuclear speck Biological process termination of RNA polymerase I transcription regulation of transcription, DNA-templated phosphorylation of RNA polymerase II C-terminal domain transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping transcription by RNA polymerase II transcription, DNA-templated cellular response to DNA damage stimulus global genome nucleotide-excision repair transcription-coupled nucleotide-excision repair transcription initiation from RNA polymerase II promoter nucleotide-excision repair, DNA incision DNA repair nucleotide-excision repair nucleotide-excision repair, preincision complex stabilization nucleotide-excision repair, preincision complex assembly nucleotide-excision repair, DNA incision, 5'-to lesion DNA duplex unwinding positive regulation of ATP-dependent activity nucleotide-excision repair, DNA duplex unwinding nucleotide-excision repair, DNA incision, 3'-to lesion transcription elongation from RNA polymerase I promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2968 14885 Ensembl ENSG00000213780 ENSMUSG00000001524 UniProt Q92759 O70422 RefSeq (mRNA) NM_001517 NM_010364 RefSeq (protein) NP_001508 NP_034494 Location (UCSC) Chr 6: 30.91 – 30.91 Mb Chr 17: 35.98 – 35.98 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

General transcription factor IIH subunit 4 is a protein that in humans is encoded by the GTF2H4 gene. ^{[5] [6]}

Interactions

GTF2H4 has been shown to interact with:

• GTF2F1, ^[7]
• MED21, ^[7]
• POLR2A, ^[7]
• TATA binding protein, ^[7]
• Transcription Factor II B, ^[7] and
• XPB. ^{[5] [8]}

See also

• Transcription Factor II H

References

1. GRCh38: Ensembl release 89: ENSG00000213780 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001524 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Marinoni JC, Roy R, Vermeulen W, Miniou P, Lutz Y, Weeda G, Seroz T, Gomez DM, Hoeijmakers JH, Egly JM (Apr 1997). "Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH". EMBO J. 16 (5): 1093–102. doi:10.1093/emboj/16.5.1093. PMC   1169708 . PMID   9118947.
6. "Entrez Gene: GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa".
7. Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. Bibcode:1997PNAS...94.5605S. doi: 10.1073/pnas.94.11.5605 . PMC   20825 . PMID   9159119.
8. Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, Jaspers NG, Raams A, Argentini M, van der Spek PJ, Botta E, Stefanini M, Egly JM, Aebersold R, Hoeijmakers JH, Vermeulen W (Jul 2004). "A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A". Nat. Genet. 36 (7): 714–9. doi: 10.1038/ng1387 . PMID   15220921.

Further reading

• Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". J. Biomed. Sci. 5 (1): 24–7. doi:10.1007/BF02253352. PMID   9570510.
• Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447-9. Bibcode:1998CBio....8.R447Y. doi: 10.1016/S0960-9822(98)70289-1 . PMID   9651670. S2CID   15480646.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Blau J, Xiao H, McCracken S, O'Hare P, Greenblatt J, Bentley D (1996). "Three functional classes of transcriptional activation domain". Mol. Cell. Biol. 16 (5): 2044–55. doi:10.1128/MCB.16.5.2044. PMC   231191 . PMID   8628270.
• Drapkin R, Le Roy G, Cho H, Akoulitchev S, Reinberg D (1996). "Human cyclin-dependent kinase-activating kinase exists in three distinct complexes". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6488–93. Bibcode:1996PNAS...93.6488D. doi: 10.1073/pnas.93.13.6488 . PMC   39050 . PMID   8692842.
• Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. doi:10.1126/science.274.5287.605. PMID   8849451. S2CID   13266489.
• Parada CA, Roeder RG (1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain". Nature. 384 (6607): 375–8. Bibcode:1996Natur.384..375P. doi:10.1038/384375a0. PMID   8934526. S2CID   4278432.
• García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes". J. Biol. Chem. 272 (11): 6951–8. doi: 10.1074/jbc.272.11.6951 . PMID   9054383.
• Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme". Mol. Cell. Biol. 17 (4): 1817–23. doi:10.1128/mcb.17.4.1817. PMC   232028 . PMID   9121429.
• Rossignol M, Kolb-Cheynel I, Egly JM (1997). "Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH". EMBO J. 16 (7): 1628–37. doi:10.1093/emboj/16.7.1628. PMC   1169767 . PMID   9130708.
• Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. Bibcode:1997PNAS...94.5605S. doi: 10.1073/pnas.94.11.5605 . PMC   20825 . PMID   9159119.
• García-Martínez LF, Mavankal G, Neveu JM, Lane WS, Ivanov D, Gaynor RB (1997). "Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription". EMBO J. 16 (10): 2836–50. doi:10.1093/emboj/16.10.2836. PMC   1169892 . PMID   9184228.
• Nekhai S, Shukla RR, Kumar A (1997). "A human primary T-lymphocyte-derived human immunodeficiency virus type 1 Tat-associated kinase phosphorylates the C-terminal domain of RNA polymerase II and induces CAK activity". J. Virol. 71 (10): 7436–41. doi:10.1128/JVI.71.10.7436-7441.1997. PMC   192089 . PMID   9311822.
• Cujec TP, Okamoto H, Fujinaga K, Meyer J, Chamberlin H, Morgan DO, Peterlin BM (1997). "The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II". Genes Dev. 11 (20): 2645–57. doi:10.1101/gad.11.20.2645. PMC   316603 . PMID   9334327.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Li XY, Green MR (1998). "The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor". Genes Dev. 12 (19): 2992–6. doi:10.1101/gad.12.19.2992. PMC   317190 . PMID   9765201.
• Ping YH, Rana TM (1999). "Tat-associated kinase (P-TEFb): a component of transcription preinitiation and elongation complexes". J. Biol. Chem. 274 (11): 7399–404. doi: 10.1074/jbc.274.11.7399 . PMID   10066804.

External links

• GTF2H4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)