HOXB7

HOXB7
Identifiers
Aliases	HOXB7 , HHO.C1, HOX2, HOX2C, Hox-2.3, homeobox B7
External IDs	OMIM: 142962 MGI: 96188 HomoloGene: 55828 GeneCards: HOXB7
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q21.32 Start 48,607,232 bp [1] End 48,633,572 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 D|11 59.82 cM Start 96,177,449 bp [2] End 96,180,988 bp [2]
RNA expression pattern Bgee Top expressed in corpus epididymis caput epididymis endometrium renal cortex adipose tissue abdominal fat vagina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity sequence-specific DNA binding DNA binding GO:0001948 protein binding GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Cellular component nucleus nucleoplasm cytosol nuclear body Biological process multicellular organism development embryonic skeletal system morphogenesis myeloid cell differentiation positive regulation of branching involved in ureteric bud morphogenesis regulation of transcription, DNA-templated transcription, DNA-templated anterior/posterior pattern specification transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3217	15415
Ensembl	ENSG00000260027	ENSMUSG00000038721
UniProt	P09629	P09024
RefSeq (mRNA)	NM_004502	NM_010460
RefSeq (protein)	NP_004493	NP_034590
Location (UCSC)	Chr 17: 48.61 – 48.63 Mb	Chr 11: 96.18 – 96.18 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein Hox-B7 is a protein that in humans is encoded by the HOXB7 gene. ^{[5] [6]}

Function

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma. ^[7]

Interactions

HOXB7 has been shown to interact with PBX1 ^[8] and CREB-binding protein. ^[9]

See also

• Homeobox

References

1. GRCh38: Ensembl release 89: ENSG00000260027 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038721 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID   1973146.
6. Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–553. doi:10.1016/0092-8674(92)90588-4. PMID   1358459. S2CID   13370372.
7. "Entrez Gene: HOXB7 homeobox B7".
8. Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML (March 1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. 9 (6): 663–674. doi: 10.1101/gad.9.6.663 . PMID   7729685.
9. Chariot A, van Lint C, Chapelier M, Gielen J, Merville MP, Bours V (July 1999). "CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein". Oncogene. 18 (27): 4007–4014. doi: 10.1038/sj.onc.1202776 . PMID   10435624.

Further reading

• Baier LJ, Hannibal MC, Hanley EW, Nabel GJ (1991). "Lymphoid expression and TATAA binding of a human protein containing an Antennapedia homeodomain". Blood. 78 (4): 1047–1055. doi: 10.1182/blood.V78.4.1047.1047 . PMID   1678287.
• Peverali FA, D'Esposito M, Acampora D, Bunone G, Negri M, Faiella A, Stornaiuolo A, Pannese M, Migliaccio E, Simeone A (1990). "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation. 45 (1): 61–69. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID   1981366.
• Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A, Faiella A, Stornaiuolo A, Russo G, Simeone A (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation. 40 (3): 191–197. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID   2570724.
• Shen WF, Largman C, Lowney P, Corral JC, Detmer K, Hauser CA, Simonitch TA, Hack FM, Lawrence HJ (1989). "Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines". Proc. Natl. Acad. Sci. U.S.A. 86 (21): 8536–8540. Bibcode:1989PNAS...86.8536S. doi: 10.1073/pnas.86.21.8536 . PMC   298317 . PMID   2573064.
• Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (1989). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–10402. doi:10.1093/nar/17.24.10385. PMC   335308 . PMID   2574852.
• Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A (1989). "Organization of human class I homeobox genes". Genome. 31 (2): 745–756. doi:10.1139/g89-133. PMID   2576652.
• Simeone A, Mavilio F, Acampora D, Giampaolo A, Faiella A, Zappavigna V, D'Esposito M, Pannese M, Russo G, Boncinelli E (1987). "Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development". Proc. Natl. Acad. Sci. U.S.A. 84 (14): 4914–4918. Bibcode:1987PNAS...84.4914S. doi: 10.1073/pnas.84.14.4914 . PMC   305217 . PMID   2885844.
• Lill MC, Fuller JF, Herzig R, Crooks GM, Gasson JC (1995). "The role of the homeobox gene, HOX B7, in human myelomonocytic differentiation". Blood. 85 (3): 692–697. doi: 10.1182/blood.V85.3.692.bloodjournal853692 . PMID   7530503.
• Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML (1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. 9 (6): 663–674. doi: 10.1101/gad.9.6.663 . PMID   7729685.
• Corsetti MT, Levi G, Lancia F, Sanseverino L, Ferrini S, Boncinelli E, Corte G (1995). "Nucleolar localisation of three Hox homeoproteins". J. Cell Sci. 108 (1): 187–193. doi: 10.1242/jcs.108.1.187 . PMID   7738096.
• Inamori K, Takeshita K, Chiba S, Yazaki Y, Hirai H (1993). "Identification of homeobox genes expressed in human T-lymphocytes". Biochem. Biophys. Res. Commun. 196 (1): 203–208. doi:10.1006/bbrc.1993.2235. PMID   8105782.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Miano JM, Firulli AB, Olson EN, Hara P, Giachelli CM, Schwartz SM (1996). "Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells". Proc. Natl. Acad. Sci. U.S.A. 93 (2): 900–905. Bibcode:1996PNAS...93..900M. doi: 10.1073/pnas.93.2.900 . PMC   40155 . PMID   8570656.
• Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–115. doi:10.1159/000134320. PMID   8646877.
• Caré A, Silvani A, Meccia E, Mattia G, Stoppacciaro A, Parmiani G, Peschle C, Colombo MP (1996). "HOXB7 constitutively activates basic fibroblast growth factor in melanomas". Mol. Cell. Biol. 16 (9): 4842–4851. doi:10.1128/mcb.16.9.4842. PMC   231486 . PMID   8756643.
• LeBrun DP, Matthews BP, Feldman BJ, Cleary ML (1997). "The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains". Oncogene. 15 (17): 2059–2067. doi: 10.1038/sj.onc.1201367 . PMID   9366523.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Stelnicki EJ, Kömüves LG, Kwong AO, Holmes D, Klein P, Rozenfeld S, Lawrence HJ, Adzick NS, Harrison M, Largman C (1998). "HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development". J. Invest. Dermatol. 110 (2): 110–115. doi: 10.1046/j.1523-1747.1998.00092.x . PMID   9457903.

External links

• HOXB7+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.