Nuclear protein

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Diagram of nuclear uptake of proteins Diagram of nuclear uptake of protein.jpg
Diagram of nuclear uptake of proteins

A nuclear protein is a protein found in the cell nucleus. [1] Proteins are transported inside the nucleus with they help of the nuclear pore complex, which acts a barrier between cytoplasm and nuclear membrane. Many nuclear proteins contain positively charged amino acids such as Lysine and Arginine which acts as a signal to allow the protein to get transported into the nucleus while maintaining their fold.[ citation needed ] The import and export of proteins through the nuclear pore complex plays a fundamental role in gene regulation and other biological functions. [2] [3]

The Nuclear Protein Database (NPD) is a database of proteins thought or known to be localized to the cell nucleus from over 1300 species of vertebrates. [4]

References

  1. ↑ "MeSH Browser". meshb.nlm.nih.gov. Retrieved 2019-05-12.
  2. ↑ Freitas N, Cunha C (December 2009). "Mechanisms and signals for the nuclear import of proteins". Current Genomics. 10 (8): 550–7. doi:10.2174/138920209789503941. PMC   2817886 . PMID   20514217.
  3. ↑ Jühlen R, Fahrenkrog B (December 2018). "Moonlighting nuclear pore proteins: tissue-specific nucleoporin function in health and disease". Histochemistry and Cell Biology. 150 (6): 593–605. doi:10.1007/s00418-018-1748-8. PMID   30361777. S2CID   53030528.
  4. ↑ Dellaire, G.; Farrall, R.; Bickmore, W. A. (2003-01-01). "The Nuclear Protein Database (NPD): sub-nuclear localisation and functional annotation of the nuclear proteome". Nucleic Acids Research. 31 (1): 328–330. doi:10.1093/nar/gkg018. ISSN   1362-4962. PMC   165465 . PMID   12520015.


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