Gem-associated protein 6

Last updated
GEMIN6
Protein GEMIN6 PDB 1y96.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GEMIN6 , gem nuclear organelle associated protein 6
External IDs OMIM: 607006 MGI: 1914492 HomoloGene: 11711 GeneCards: GEMIN6
Orthologs
SpeciesHumanMouse
Entrez

79833

67242

Ensembl

ENSG00000152147

ENSMUSG00000055760

UniProt

Q8WXD5

Q9CX53

RefSeq (mRNA)

NM_024775

NM_026053
NM_001355458

RefSeq (protein)

NP_079051

NP_080329
NP_001342387

Location (UCSC) Chr 2: 38.75 – 38.79 Mb Chr 17: 80.53 – 80.54 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Gem-associated protein 6 is a protein that in humans is encoded by the GEMIN6 gene. [5] [6] The gem-associated proteins are those found in the gems of Cajal bodies.

Contents

Function

GEMIN6 is part of a large macromolecular complex, the SMN localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM] [6]

Interactions

Gem-associated protein 6 has been shown to interact with gem-associated protein 7. [7] [8]

Related Research Articles

Gideon Dreyfuss is an American biochemist who is the Isaac Norris Professor of Biochemistry and Biophysics at the University of Pennsylvania School of Medicine and an investigator of the Howard Hughes Medical Institute. He was elected to the National Academy of Sciences in 2012.

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<span class="mw-page-title-main">Gem-associated protein 2</span> Protein-coding gene in the species Homo sapiens

Gem-associated protein 2 (GEMIN2), also called survival of motor neuron protein-interacting protein 1 (SIP1), is a protein that in humans is encoded by the GEMIN2 gene.

<span class="mw-page-title-main">DDX20</span> Protein-coding gene in the species Homo sapiens

Probable ATP-dependent RNA helicase DDX20, also known as DEAD-box helicase 20 and gem-associated protein 3 (GEMIN3), is an enzyme that in humans is encoded by the DDX20 gene.

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<span class="mw-page-title-main">Gem-associated protein 7</span> Protein-coding gene in the species Homo sapiens

Gem-associated protein 7 is a protein that in humans is encoded by the GEMIN7 gene. The gem-associated proteins are those found in the gems of Cajal bodies.

<span class="mw-page-title-main">Gem-associated protein 4</span> Protein-coding gene in the species Homo sapiens

Gem-associated protein 4 is a protein that in humans is encoded by the GEMIN4 gene.

<span class="mw-page-title-main">Gem-associated protein 5</span> Protein-coding gene in the species Homo sapiens

Gem-associated protein 5 is a protein that in humans is encoded by the GEMIN5 gene.

<span class="mw-page-title-main">GEMIN8</span> Protein-coding gene in the species Homo sapiens

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000152147 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055760 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". The Journal of Biological Chemistry. 277 (9): 7540–5. doi: 10.1074/jbc.M110141200 . PMID   11748230.
  6. 1 2 "Entrez Gene: GEMIN6 gem (nuclear organelle) associated protein 6".
  7. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
  8. ↑ Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". The Journal of Biological Chemistry. 277 (35): 31957–62. doi: 10.1074/jbc.M203478200 . PMID   12065586.

Further reading

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